The Oral Iron Chelator Deferasirox Induces Apoptosis in Myeloid Leukemia Cells by Targeting Caspase

2011 ◽  
Vol 126 (4) ◽  
pp. 241-245 ◽  
Author(s):  
Jung-Lim Kim ◽  
Han-Na Kang ◽  
Myoung Hee Kang ◽  
Young A. Yoo ◽  
Jun Suk Kim ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Iron Chelator ◽  
Oral Iron ◽  
Leukemia Cells ◽  
Oral Iron Chelator

Abstract 4091: The oral iron chelator, deferasirox, induces apoptosis in myeloid leukemia cells through caspase-dependent activation

2011 ◽  
Author(s):  
Jung-Lim Kim ◽  
Han-Na Kang ◽  
Myoung Hee Kang ◽  
Jun Suk Kim ◽  
Sang-Cheul Oh ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Iron Chelator ◽  
Oral Iron ◽  
Leukemia Cells ◽  
Oral Iron Chelator

scholarly journals The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1

2009 ◽  
Vol 100 (5) ◽  
pp. 970-977 ◽  
Author(s):  
Junko H. Ohyashiki ◽  
Chiaki Kobayashi ◽  
Ryoko Hamamura ◽  
Seiichi Okabe ◽  
Tetsuzo Tauchi ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Iron Chelator ◽  
Oral Iron ◽  
Leukemia Cells ◽  
Oral Iron Chelator

Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats

2007 ◽  
Vol 5 (4) ◽  
pp. 253-261 ◽  
Author(s):  
Jacob Ablin ◽  
Oded Shalev ◽  
Elimelech Okon ◽  
Fanny Karmeli ◽  
Daniel Rachmilewitz
Keyword(s):  
Experimental Colitis ◽  
Iron Chelator ◽  
Gastric Ulceration ◽  
Oral Iron ◽  
Oral Iron Chelator

Critical Comparison of Novel and Existing Methods of Compliance Assessment During a Clinical Trial of an Oral Iron Chelator

1994 ◽  
Vol 34 (9) ◽  
pp. 944-949 ◽  
Author(s):  
Doreen Matsui ◽  
Christine Hermann ◽  
Julia Klein ◽  
Matitiahu Berkovitch ◽  
Nancy Olivieri ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Iron Chelator ◽  
Oral Iron ◽  
Compliance Assessment ◽  
Critical Comparison ◽  
Oral Iron Chelator

scholarly journals Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo

Oncotarget ◽  
2018 ◽  
Vol 9 (47) ◽  
pp. 28434-28444 ◽  
Author(s):  
Shuhei Shinoda ◽  
Seiji Kaino ◽  
Shogo Amano ◽  
Hirofumi Harima ◽  
Toshihiko Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Iron Chelator ◽  
Oral Iron ◽  
Cancer Cell Growth ◽  
Oral Iron Chelator

Relationship between the pharmacokinetics and iron excretion pharmacodynamics of the new oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one in patients with thalassemia

1991 ◽  
Vol 50 (3) ◽  
pp. 294-298 ◽  
Author(s):  
Doreen Matsui ◽  
Julia Klein ◽  
Christine Hermann ◽  
Victor Grunau ◽  
Robert Mcclelland ◽  
...  
Keyword(s):  
Iron Chelator ◽  
Oral Iron ◽  
Iron Excretion ◽  
Oral Iron Chelator

scholarly journals The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

2012 ◽  
Vol 1 (3) ◽  
pp. 2 ◽  
Author(s):  
Majda Hadziahmetovic ◽  
Miroslav Pajic ◽  
Steven Grieco ◽  
Ying Song ◽  
Delu Song ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Iron Chelator ◽  
Oral Iron ◽  
Oral Iron Chelator

Effect of Oral Iron Chelator L1 on Iron Absorption in Man

1998 ◽  
Vol 850 (1 COOLEY'S ANEM) ◽  
pp. 466-468 ◽  
Author(s):  
B. DRESOW ◽  
R. FISCHER ◽  
P. NIELSEN ◽  
E. E. GABBE ◽  
A. PIGA
Keyword(s):  
Iron Absorption ◽  
Iron Chelator ◽  
Oral Iron ◽  
Oral Iron Chelator

P-113 The efficacy and tolerabilityof ICL670, a once-daily oral iron chelator, in patients with myelodysplastic syndrome (MDS) and iron overload

2005 ◽  
Vol 29 ◽  
pp. S67 ◽  
Author(s):  
N. Gattermann ◽  
M. Cazzola ◽  
P. Greenberg ◽  
J. Maertens ◽  
D. Soulieres ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Iron Overload ◽  
Iron Chelator ◽  
Oral Iron ◽  
Once Daily ◽  
Oral Iron Chelator
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