Aquaporin 4 Antibodies in the Cerebrospinal Fluid Are Helpful in Diagnosing Chinese Patients with Neuromyelitis Optica

2012 ◽  
Vol 19 (2) ◽  
pp. 96-102 ◽  
Author(s):  
Youming Long ◽  
Wei Qiu ◽  
Zhengqi Lu ◽  
Jian Bao ◽  
Aimin Wu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuromyelitis Optica ◽  
Aquaporin 4 ◽  
Chinese Patients

Features of anti-aquaporin 4 antibody-seropositive Chinese patients with neuromyelitis optica spectrum optic neuritis

2015 ◽  
Vol 262 (10) ◽  
pp. 2293-2304 ◽  
Author(s):  
Hongyang Li ◽  
Yanling Wang ◽  
Quangang Xu ◽  
Aidi Zhang ◽  
Huanfen Zhou ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Aquaporin 4 ◽  
Chinese Patients ◽  
Aquaporin 4 Antibody

scholarly journals Cerebrospinal fluid aquaporin‐4 antibody levels in neuromyelitis optica attacks

2014 ◽  
Vol 76 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Douglas Kazutoshi Sato ◽  
Dagoberto Callegaro ◽  
Frederico M. Haidar Jorge ◽  
Ichiro Nakashima ◽  
Shuhei Nishiyama ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuromyelitis Optica ◽  
Aquaporin 4 ◽  
Antibody Levels ◽  
Aquaporin 4 Antibody

scholarly journals Short segment myelitis as the initial and only manifestation of aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorders

2020 ◽  
Vol 13 ◽  
pp. 175628641989859
Author(s):  
Wei Fang* ◽  
Yang Zheng* ◽  
Fan Yang ◽  
Meng-Ting Cai ◽  
Chun-Hong Shen ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Immunoglobulin G ◽  
Correct Diagnosis ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Chinese Patients ◽  
Careful Study ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Short Segment ◽  
Spectrum Disorders

Background: Short segment myelitis (SSM, < 3 vertebral segments) is an under-recognized initial manifestation of neuromyelitis optica spectrum disorders (NMOSD). Though infrequent, failure to recognize SSM in patients with NMOSD would lead to incorrect diagnosis and treatment. Therefore, delineation of features of NMOSD-associated SSM is of paramount importance. Objective: Our study aimed to determine the demographic, clinical and radiological features of NMOSD-associated SSM, and compare those with NMOSD-associated longitudinally extensive transverse myelitis (LETM) and multiple sclerosis (MS)-associated SSM, respectively. Methods: Chinese patients presenting initially only with acute myelitis and diagnosed with NMOSD ( n = 46) and MS ( n = 11) were included. Clinical, serological, imaging and disability data were collected. Mann–Whitney U test or two-tailed Fisher’s exact tests were used to analyse the data. Results: Of the 46 enrolled NMOSD patients, 34 (74%) collectively had 38 LETM lesions, while 12 (26%) had 14 SSM lesions. When compared with LETM, NMOSD presenting with SSM were more likely to have a delayed diagnosis and a lower level of disability at nadir during the first attack. T1-weighted imaging hypointensity was more prominent in NMOSD-associated LETM lesions than NMOSD-associated SSM lesions. When compared with MS-associated SSM, NMOSD-associated SSM lesions were more likely to be centrally located, grey matter involving and transversally extensive on axial imaging and spanned no less than 2 vertebral segments on sagittal imaging. Conclusion: These findings suggest that SSM does not preclude the possibility of a NMOSD diagnosis. Testing for serum aquaporin-4 immunoglobulin G (AQP4-IgG) and careful study of lesions on spinal cord magnetic resonance imaging could aid in an earlier and correct diagnosis.

scholarly journals Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

2010 ◽  
Vol 7 (1) ◽  
pp. 52 ◽  
Author(s):  
Sven Jarius ◽  
Diego Franciotta ◽  
Friedemann Paul ◽  
Klemens Ruprecht ◽  
Roberto Bergamaschi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuromyelitis Optica ◽  
Aquaporin 4

The role of aquaporin-4 antibodies in Chinese patients with neuromyelitis optica

2013 ◽  
Vol 20 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Yang Yang ◽  
De-hui Huang ◽  
Wei-ping Wu ◽  
Lei Wu ◽  
Li-feng Chen ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Aquaporin 4 ◽  
Chinese Patients

Neuromyelitis optica (Devic's disease) in a patient with syphilis

2007 ◽  
Vol 14 (2) ◽  
pp. 268-271 ◽  
Author(s):  
Robert A Wilcox ◽  
James Burrow ◽  
Mark Slee ◽  
Jamie Craig ◽  
Dominic Thyagarajan
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Clinical Syndrome ◽  
Aquaporin 4 ◽  
Serum Autoantibody ◽  
Devic's Disease ◽  
Cranial Mri ◽  
Post Infectious

The patient initially presented with bilateral optic neuritis and periventricular cranial MRI abnormalities in the context of syphilis. Blood was positive but cerebrospinal fluid testing was negative for specific syphilis markers and he was oligoclonal cerebrospinal fluid (CSF) band negative. He initially responded well to penicillin and corticosteriod treatment, but went on to develop the clinical syndrome of neuromyelitis optica (NMO). Testing for the presence of the serum autoantibody for aquaporin-4 was negative. This patient appears to represent another case of post-infectious NMO. Possible pathogenesis of this post-syphilis NMO syndrome in the patient is discussed. Multiple Sclerosis 2008; 14: 268—271. http://msj.sagepub.com

Human aquaporin 4 gene polymorphisms in Chinese patients with neuromyelitis optica

2014 ◽  
Vol 274 (1-2) ◽  
pp. 192-196 ◽  
Author(s):  
Qiu Wei ◽  
Chang Yanyu ◽  
Li Rui ◽  
Li Caixia ◽  
Long Youming ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Gene Polymorphisms ◽  
Aquaporin 4 ◽  
Chinese Patients

Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: Results from 211 lumbar punctures

2011 ◽  
Vol 306 (1-2) ◽  
pp. 82-90 ◽  
Author(s):  
S. Jarius ◽  
F. Paul ◽  
D. Franciotta ◽  
K. Ruprecht ◽  
M. Ringelstein ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuromyelitis Optica ◽  
Aquaporin 4 ◽  
Aquaporin 4 Antibody
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