Transient Pupillary Light Reflex in Relation to Fundus Autofluorescence and Dark-Adapted Perimetry in Typical Retinitis Pigmentosa

2012 ◽  
Vol 47 (3) ◽  
pp. 113-121 ◽  
Author(s):  
Yong Liu ◽  
Dan Ning Liu ◽  
Xiao Hong Meng ◽  
Zheng Qin Yin
Keyword(s):  
Retinitis Pigmentosa ◽  
Fundus Autofluorescence ◽  
Pupillary Light Reflex ◽  
Light Reflex ◽  
Pupillary Light

scholarly journals Correlation between Transient Pupillary Light Reflex and Retinal Function Impairment in Patients with Retinitis Pigmentosa

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Yan He ◽  
Huanyu Tang ◽  
Gang Wang ◽  
Bangqi Ren ◽  
Yi Wang ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
White Light ◽  
Visual Function ◽  
Pupillary Light Reflex ◽  
Clinical Approach ◽  
Retinal Sensitivity ◽  
Light Reflex ◽  
Pupillary Light ◽  
Significant Difference ◽  
Fixation Stability

Purpose. To investigate the relationship between transient pupillary light reflex (PLR) and visual function in patients with retinitis pigmentosa (RP). Methods. A retrospective study was performed with 137 eyes of 73 patients with RP. Transient pupillary light reflex was measured by the vision monitor system (MonColor; Metrovision, France). Dark-adapted transient PLRs were elicited by four specific levels of stimulus luminance (−5, −3, −1, and 0 log cd/m2, blue or white light). Best-corrected visual acuity (BCVA) was recorded based on Early Treatment Diabetic Retinopathy Study (ETDRS) acuity charts. Fixation stability and retinal sensitivity of radial 10° areas were measured with microperimetry. The retinal sensitivity (RS) was divided into central RS (fovea and radial 1° areas) and peripheral RS (radial 3° and 5° areas from the fovea). The patients were further classified into 2 groups (P1 > 75% and P1 < 75%) according to fixation stability. Spearman’s correlation was performed to identify significant associations between BCVA, fixation stability, RS, and PLR. Results. Under the stimuli of the same color light, relative pupillary constriction (RPC), latency, or velocity of constriction in the same patients was statistically different in multiple luminance, respectively. Under the same luminance, blue light induced greater RPC and velocity (except for −3 log cd/m2) than white light. Most patients showed varying degrees of threshold elevation and visual function deficiency. Besides, there was a statistically significant difference in the distribution of BCVA, MRS, or fixation stability under different thresholds. The correlation between pupillary constrictive area (PCA) and retinal sensitivity was mainly determined by the peripheral region. Moreover, patients with stable fixation showed a greater correlation between PCA and RS. Conclusion. PLR induced by specific colors and luminance may serve as a promising clinical approach for assessing and monitoring rod function in advanced RP patients.

scholarly journals Effect of Topical Anti-Glaucoma Medications on Late Pupillary Light Reflex, as Evaluated by Pupillometry

2015 ◽  
Vol 6 ◽  
Author(s):  
Shakoor Ba-Ali ◽  
Birgit Sander ◽  
Adam Elias Brøndsted ◽  
Henrik Lund-Andersen
Keyword(s):  
Pupillary Light Reflex ◽  
Light Reflex ◽  
Pupillary Light

scholarly journals Relationship between Human Pupillary Light Reflex and Circadian System Status

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162476 ◽  
Author(s):  
Maria Angeles Bonmati-Carrion ◽  
Konstanze Hild ◽  
Cheryl Isherwood ◽  
Stephen J. Sweeney ◽  
Victoria L. Revell ◽  
...  
Keyword(s):  
Circadian System ◽  
Pupillary Light Reflex ◽  
Light Reflex ◽  
Pupillary Light

scholarly journals Pupillary Light Reflex is Altered in Adolescent Depression

2017 ◽  
pp. S277-S284 ◽  
Author(s):  
A. MESTANIKOVA ◽  
I. ONDREJKA ◽  
M. MESTANIK ◽  
D. CESNEKOVA ◽  
Z. VISNOVCOVA ◽  
...  
Keyword(s):  
Nervous System ◽  
Major Depression ◽  
Parasympathetic Nervous System ◽  
Dynamic Balance ◽  
Pupillary Light Reflex ◽  
Control Group ◽  
Light Reflex ◽  
Pupillary Light ◽  
Adolescent Patients ◽  
Depressive Group

Major depressive disorder is associated with abnormal autonomic regulation which could be noninvasively studied using pupillometry. However, the studies in adolescent patients are rare. Therefore, we aimed to study the pupillary light reflex (PLR), which could provide novel important information about dynamic balance between sympathetic and parasympathetic nervous system in adolescent patients suffering from major depression. We have examined 25 depressive adolescent girls (age 15.2±0.3 year) prior to pharmacotherapy and 25 age/gender-matched healthy subjects. PLR parameters were measured separately for both eyes after 5 min of rest using Pupillometer PLR-2000 (NeurOptics, USA). The constriction percentual change for the left eye was significantly lower in depressive group compared to control group (-24.12±0.87 % vs. –28.04±0.96%, p˂0.01). Furthermore, average constriction velocity and maximum constriction velocity for the left eye were significantly lower in depressive group compared to control group (p˂0.05, p˂0.01, respectively). In contrast, no significant between-groups differences were found for the right eye. Concluding, this study revealed altered PLR for left eye indicating a deficient parasympathetic activity already in adolescent major depression. Additionally, the differences between left and right eye could be related to functional lateralization of autonomic control in the central nervous system.

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