scholarly journals Role of Growth Hormone Deficiency and Treatment in Chronic Kidney Disease

2011 ◽  
Vol 1 (3) ◽  
pp. 174-182 ◽  
Author(s):  
Diptesh Gupta ◽  
Michael Gardner ◽  
Adam Whaley-Connell
Keyword(s):  
Chronic Kidney Disease ◽  
Growth Hormone ◽  
Kidney Disease ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency

The role of growth hormone in determining birth size and early postnatal growth, using congenital growth hormone deficiency (GHD) as a model

2005 ◽  
Vol 63 (2) ◽  
pp. 223-231 ◽  
Author(s):  
Ameeta Mehta ◽  
Peter C. Hindmarsh ◽  
Richard G. Stanhope ◽  
James P. G. Turton ◽  
Tim J. Cole ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Postnatal Growth ◽  
Hormone Deficiency ◽  
Birth Size

scholarly journals IGF1 for the diagnosis of growth hormone deficiency in children and adolescents: a reappraisal

2020 ◽  
Vol 9 (11) ◽  
pp. 1095-1102
Author(s):  
Anastasia Ibba ◽  
Francesca Corrias ◽  
Chiara Guzzetti ◽  
Letizia Casula ◽  
Mariacarolina Salerno ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Children And Adolescents ◽  
Growth Hormone Deficiency ◽  
Biochemical Parameters ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Area Under The Curve ◽  
Hormone Deficiency ◽  
Short Children

A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two children and adolescents with GHD ((63 organic/genetic (OGHD), 79 idiopathic (IGHD)) and 658 short non-GHD children (median age 10.4 years) were included in the analysis. The two groups were subdivided according to age (G1 <6, G2 6 <9, G3 9 <12, G4 ≥12) and to pubertal status. Serum IGFI was measured by the same chemiluminescence assay in all samples and expressed as age- and sex-based SDS. Receiver operating characteristic (ROC) analysis was used to evaluate the optimal IGF1 SDS cut-off and the diagnostic accuracy. Median IGF1 SDS was significantly lower in the GHD than in non-GHD patients. The area under the curve (AUC) was 0.69, with the best IGF1 cut-off of −1.5 SDS (sensitivity 67.61%, specificity 62.62%). The AUC was 0.75 for OGHD and 0.63 for IGHD. The accuracy was better in the pubertal (AUC = 0.81) than the prepubertal group (AUC = 0.64). In our cohort, IGF1 measurement has poor accuracy in discriminating GHD from non-GHD. Our findings confirm and reinforce the belief that IGF1 values should not be used alone in the diagnosis of GHD but should be interpreted in combination with other clinical and biochemical parameters.

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