Surfactant Lavage Therapy for Meconium Aspiration Syndrome: A Systematic Review and Meta-Analysis

Neonatology ◽  
2012 ◽  
Vol 101 (3) ◽  
pp. 183-191 ◽  
Author(s):  
Hyun Jin Choi ◽  
Seokyung Hahn ◽  
Joongyub Lee ◽  
Byung-Joo Park ◽  
Soon Min Lee ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration

scholarly journals The Effects of Different Types of Steroids on Clinical Outcomes in Neonates with Meconium Aspiration Syndrome: A Systematic Review, Meta-Analysis, and GRADE Assessment

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1281
Author(s):  
Nanthida Phattraprayoon ◽  
Teerapat Ungtrakul ◽  
Wimonchat Tangamornsuksan
Keyword(s):  
Respiratory Distress ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Pulmonary Inflammation ◽  
Neonatal Morbidity ◽  
Meconium Aspiration Syndrome ◽  
Cochrane Library ◽  
Oxygen Requirement ◽  
Meconium Aspiration ◽  
Relative Risks

Background and Objectives: Meconium aspiration syndrome (MAS) is a condition caused by the aspiration of meconium-stainted amniotic fluid into the lungs, resulting in pulmonary inflammation, neonatal morbidity, and mortality. It is important that these MAS infants receive appropriate care to avoid further complications. Steroids have an anti-inflammatory effect and may be effective in the management of MAS. The objective of the this study was to evaluate the effect of different steroids on clinical outcomes in infants with MAS. Materials and Methods: We systematically searched of PubMed/Medline, Scopus, Embase, Clinical Trials.gov, and Cochrane Library databases from inception to 24 January 2021 without language restriction. Only randomized controlled trials (RCTs) evaluating the effects of steroids in neonates with MAS were included. We calculated relative risks and weighted mean differences (MDs) with 95% confidence intervals (CIs) using a random-effects model to determine the associations between MAS and steroids and GRADE approach was employed for quality of evidence. The main outcomes measures were duration of respiratory distress, oxygen requirement, hospitalization, need for mechanical ventilation, death, and adverse drug reactions. Results: Seven RCTs involving 397 patients were analyzed. Nebulized budesonide and intravenous (IV) methylprednisolone shortened the duration of respiratory distress (MD, −2.46 days; 95% CI, −3.09 to −1.83 and MD, −3.30 days; 95% CI, −4.07 to −2.52, respectively) (moderate certainty). There was a reduction in duration of oxygen requirement in nebulized budesonide use (MD, −2.40 days; 95% CI, −3.40 to −1.40) (low certainty) and IV methylprednisolone use (MD, −3.30 days; 95% CI, −4.07 to −2.52) (moderate certainty). Nebulized budesonide shortened hospitalization stay (MD, −4.47 days; 95% CI, −8.64 to −0.30 days) (low certainty) as IV methylprednisolone use (MD, −7.23 days; 95% CI, −8.19 to −6.07 days) (moderate certainty). None of steroids benefits in death (low certainty). Conclusions: Certain types of steroids may benefit the respiratory aspect, but there was no decrease in mortality in MAS infants.

scholarly journals Effect of Meconium Stained Amniotic Fluid on The Risk of Infants Asphyxia: A Meta-Analysis

2020 ◽  
Author(s):  
Alfiati Nanda Widiyaningrum ◽  
◽  
Bhisma Murti ◽  
Eti Poncorini Pamungkasari ◽  
◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
English Language ◽  
Meta Analysis ◽  
Birth Asphyxia ◽  
Fixed Effect Model ◽  
Meconium Aspiration Syndrome ◽  
High Morbidity ◽  
Cross Sectional ◽  
Meconium Aspiration ◽  
Meconium Stained Amniotic Fluid

ABSTRACT Background: Meconium aspiration syndrome refers to the aspiration of meconium and amniotic fluid by the fetus. It can occur when the fetus is still in the uterus, passing through the birth canal or when it takes its first breath after birth. Meconium aspiration is a serious condition with high morbidity and mortality. This study aimed to examine the effect of meconium stained amniotic fluid on the risk of infants asphyxia. Subjects and Method: Meta analysis and systematic review was conducted by collecting published articles from PubMed, Google Scholar, Clinical Key, Science Direct, and Springer Link databases. Keywords used risk factor, asphyxia, birth asphyxia, meconium stained amniotic, meconium stained liquor, and cross sectional. The inclusion criteria were full text, using English language, using cross-sectional study design, and reporting adjusted odds ratio. The study population was infants. Intervention was meconium stained amniotic liquid with comparison clean amniotic liquid. The study outcome was asphyxia. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed by fixed effect model using Revman 5.3. Results: 7 studies from Ethiopia reported that meconium stained amniotic fluid increased the risk of asphyxia in infants 5.83 (aOR= 5.83; CI 95%= 4.15 to 8.20; p <0.001). Conclusion: Meconium stained amniotic fluid increases the risk of asphyxia in infants. Keywords: meconium, amniotic fluid, asphyxia, infants Correspondence: Alfiati Nanda Widiyaningrum. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile:081327524537. DOI: https://doi.org/10.26911/the7thicph.03.130

scholarly journals Surfactant Lavage for Neonatal Meconium Aspiration Syndrome— An Updated Meta-analysis

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Rong Hui ◽  
Yun-su Zou ◽  
Xiao-yu Zhou ◽  
Xiao-qing Chen ◽  
Jing-jing Pan ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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