Meloxicam, a COX-2 Inhibitor, Ameliorates Ischemia/Reperfusion Injury in Non-Heart-Beating Donor Livers

2011 ◽  
Vol 47 (3) ◽  
pp. 109-117 ◽  
Author(s):  
B. Stoffels ◽  
K. Yonezawa ◽  
Y. Yamamoto ◽  
N. Schäfer ◽  
M. Overhaus ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heart Beating ◽  
Cox 2

Reduced Ischemia–Reperfusion Injury with Isoproterenol in Non-Heart-Beating Donor Lungs

1997 ◽  
Vol 69 (2) ◽  
pp. 385-392 ◽  
Author(s):  
David R. Jones ◽  
Steven C. Hoffmann ◽  
Melanie Sellars ◽  
Thomas M. Egan
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heart Beating

Cardiac specific overexpression of COX-2 protects against ischemia/reperfusion injury

2007 ◽  
Vol 42 (6) ◽  
pp. S200
Author(s):  
Javier Inserte ◽  
Belen Molla ◽  
Victor Hernando ◽  
Paloma Martín-Sanz ◽  
Lisardo Boscá ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cox 2

Resveratrol Prevents Warm Ischemia–Reperfusion Injury in Liver Grafts From Non–Heart-Beating Donor Rats

2016 ◽  
Vol 48 (4) ◽  
pp. 1221-1225 ◽  
Author(s):  
K. Shimizu ◽  
S. Miyagi ◽  
K. Miyazawa ◽  
K. Maida ◽  
T. Kashiwadate ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Warm Ischemia ◽  
Heart Beating

Influence of Cold Storage on Renal Ischemia Reperfusion Injury after Non-Heart-Beating Donor Explantation

2004 ◽  
Vol 96 (3) ◽  
pp. e97-e102 ◽  
Author(s):  
Sven Dittrich ◽  
David A. Groneberg ◽  
Johanna von Loeper ◽  
Frank Lippek ◽  
Olaf Hegemann ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Heart Beating ◽  
Renal Ischemia Reperfusion Injury

scholarly journals Danhong Injection Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Suppression of the Neuroinflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Haixia Du ◽  
Yu He ◽  
Yuanjiang Pan ◽  
Mengdi Zhao ◽  
Zhiwei Li ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Danhong Injection ◽  
Cerebral Ischemia Reperfusion ◽  
Tnf Α ◽  
Cerebral Ischemia Reperfusion Injury ◽  
Cox 2

Neuroinflammation is one of the major causes of damage of the central nervous system (CNS) and plays a vital role in the pathogenesis of cerebral ischemia, which can result in long-term disability and neuronal death. Danhong injection (DHI), a traditional Chinese medicine injection, has been applied to the clinical treatment of cerebral stoke for many years. In this study, we investigated the protective effects of DHI on cerebral ischemia-reperfusion injury (CIRI) in rats and explored its potential anti-neuroinflammatory properties. CIRI in adult male SD rats was induced by middle cerebral artery occlusion (MCAO) for 1 h and reperfusion for 24 h. Results showed that DHI (0.5, 1, and 2 ml/kg) dose-dependently improved the neurological deficits and alleviated cerebral infarct volume and histopathological damage of the cerebral cortex caused by CIRI. Moreover, DHI (0.5, 1, and 2 ml/kg) inhibited the mRNA expressions of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), intercellular cell adhesion molecule-1 (ICAM-1), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in ischemic brains, downregulated TNF-α, IL-1β, and monocyte chemotactic protein-1 (MCP-1) levels in serum, and reduced the neutrophil infiltration (myeloperoxidase, MPO) in ischemic brains, in a dose-dependent manner. Immunohistochemical staining results also revealed that DHI dose-dependently diminished the protein expressions of ICAM-1 and COX-2, and suppressed the activation of microglia (ionized calcium-binding adapter molecule 1, Iba-1) and astrocyte (glial fibrillary acidic protein, GFAP) in the cerebral cortex. Western blot analysis showed that DHI significantly downregulated the phosphorylation levels of the proteins in nuclear factor κB (NF-κB) and mitogen-activated protein kinas (MAPK) signaling pathways in ischemic brains. These results indicate that DHI exerts anti-neuroinflammatory effects against CIRI, which contribute to the amelioration of CNS damage.

ABLATING THE ISCHEMIA-REPERFUSION INJURY IN NON-HEART-BEATING DONOR KIDNEYS1,2

1999 ◽  
Vol 67 (2) ◽  
pp. 200-206 ◽  
Author(s):  
Arturo Hernandez ◽  
Jimmy A. Light ◽  
Diana Y. Barhyte ◽  
Mohsen Mabudian ◽  
Fred Gage
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heart Beating
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