Gastro-Oesophageal Reflux Disease Symptoms and Tooth Wear in Patients with Sjögren’s Syndrome

2011 ◽  
Vol 45 (3) ◽  
pp. 323-326 ◽  
Author(s):  
W.N.N. Wan Nik ◽  
A. Banerjee ◽  
R. Moazzez
Keyword(s):  
Sjögren’S Syndrome ◽  
Reflux Disease ◽  
Sjögren's Syndrome ◽  
Tooth Wear ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Oesophageal Reflux ◽  
Disease Symptoms ◽  
Oesophageal Reflux Disease ◽  
Sjögren‘S Syndrome

scholarly journals Activation of the Alternative NFκB Pathway Improves Disease Symptoms in a Model of Sjogren's Syndrome

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28727 ◽  
Author(s):  
Adi Gilboa-Geffen ◽  
Yochai Wolf ◽  
Geula Hanin ◽  
Naomi Melamed-Book ◽  
Marjorie Pick ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Disease Symptoms ◽  
Nfκb Pathway ◽  
Sjögren‘S Syndrome

scholarly journals Dental implants in Sjögren syndrome

2020 ◽  
Vol 30 (2) ◽  
pp. 334-340
Author(s):  
Hamidreza Daneshparvar ◽  
Nasrin Esfahanizadeh ◽  
Reza Vafadoost
Keyword(s):  
Dental Implants ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Tooth Wear ◽  
Sjogren’S Syndrome ◽  
Salivary Flow ◽  
Sjogren's Syndrome ◽  
Dental Restorations ◽  
Edentulous Patients ◽  
Sjögren‘S Syndrome

Sjögren's syndrome (SS) is a complex autoimmune disease that predominantly affects the exocrine glands, notably the salivary and lacrimal glands, resulting in dryness of the mucosa recognized as xerostomia. Chief oral complications reported by patients consist of high caries rate, burning sensation of the mucosa, early tooth loss, intensified tooth wear and repetitive failure of dental restorations. In particular, due to the decreased salivary flow, conventional removable prostheses might irritate the mucosa and lead to painful ulcerations at the borders of the denture. Implant-supported prostheses offer a unique solution to the difficulties experienced by edentulous patients with Sjögren’s syndrome. This research showed no signs of peri-implantitis or peri-implant mucositis during 7-years following the placement of implants. The present study indicates that successful long-term maintenance of dental implants can be also achieved in SS patients.

Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome

Rheumatology ◽  
2019 ◽  
Vol 59 (7) ◽  
pp. 1651-1661 ◽  
Author(s):  
Albin Björk ◽  
Gudny Ella Thorlacius ◽  
Johannes Mofors ◽  
Elina Richardsdotter Andersson ◽  
Margarita Ivanchenko ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sjögren’S Syndrome ◽  
Plasma Proteins ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Disease Symptoms ◽  
Patient Reported ◽  
Sjögren‘S Syndrome

Abstract Objectives Infections have been suggested in the pathogenesis of primary SS (pSS). Systematic studies of immune responses to microbial antigens in vivo may be performed during vaccination. In the present study, we therefore longitudinally followed patients with pSS and controls during split-virion influenza vaccination to identify pSS-specific cellular, transcriptomic and serological responses. Methods Patients without treatment (pSSUntr, n = 17), on hydroxychloroquine-treatment (pSSHCQ, n = 8), and healthy controls (n = 16) were included. Antibody titres were determined by ELISA. Plasma proteins were measured by proximity extension assay. Monocyte gene expression was assessed by Nanostring. Routine laboratory tests were performed and clinical disease symptoms were registered by questionnaires. Results pSSUntr developed higher vaccine-specific IgG titres compared with controls. Notably, anti-Ro52 autoantibody titres increased in pSSUntr but remained unchanged in pSSHCQ. No changes in disease symptoms including EULAR Sjögren's Syndrome Patient Reported Index score were registered. Twenty-four hours after vaccination, the leucocyte count in pSSUntr decreased, with a concomitant increase of CCL7 in plasma. Transcriptomic analysis in monocytes revealed differential vaccination-related expression of the NEMO/IKBKG gene, and its higher induced expression in pSSUntr associated with higher serological vaccine responses. Moreover, titres of vaccine-specific antibodies were associated with higher vaccination-induced NF-κB signalling and higher steady-state IFN signatures in monocytes, and with the levels of several plasma proteins with soluble PD-1 displaying the strongest association. Conclusion We observed augmented innate and adaptive immune responses in pSS following viral antigen exposure suggesting an underlying hyper-responsiveness to immune challenges, supporting a role for infections driving the immunopathology and acting as environmental risk factor for pSS.

scholarly journals Seven Years Follow-up of a Patient with Sjögren's Syndrome Treated with Implant-supported Fixed Prostheses

2020 ◽  
Author(s):  
Hamidreza Daneshparvar ◽  
Nasrin Esfahanizadeh ◽  
Reza Vafadoost
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Tooth Wear ◽  
Sjogren’S Syndrome ◽  
Salivary Flow ◽  
Sjogren's Syndrome ◽  
Dental Restorations ◽  
Edentulous Patients ◽  
Sjögren‘S Syndrome

Sjögren's syndrome (SS) is a complex autoimmune disease that predominantly affects the exocrine glands, notably the salivary and lacrimal glands, resulting in dryness of the mucosa recognized as xerostomia. Chief oral complications reported by patients consist of high caries rate, burning sensation of the mucosa, early tooth loss, intensified tooth wear and repetitive failure of dental restorations. In particular, due to the decreased salivary flow, conventional removable prostheses might irritate the mucosa and lead to painful ulcerations at the borders of the denture. Implant-supported prostheses offer a unique solution to the difficulties experienced by edentulous patients with Sjögren’s syndrome. This report and review of the literature discuss a 46-year-old female patient with undiagnosed Sjogren's syndrome successfully treated with dental implants and followed for 7 years.

The association of Raynaud’s phenomenon/syndrome with scleroderma and Sjögren’s syndrome – a meta-analysis

VASA ◽  
2008 ◽  
Vol 37 (Supplement 73) ◽  
pp. 26-32 ◽  
Author(s):  
Schlattmann ◽  
Höhne ◽  
Plümper ◽  
Heidrich
Keyword(s):  
Quantitative Analysis ◽  
Sjögren’S Syndrome ◽  
Mixture Model ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Raynaud’S Syndrome ◽  
Raynaud's Syndrome ◽  
Sjögren‘S Syndrome

Background: In order to analyze the prevalence of Raynaud’s syndrome in diseases such as scleroderma and Sjögren’s syndrom – a meta-analysis of published data was performed. Methods: The PubMed data base of the National Library of Medicine was used for studies dealing with Raynaud’s syndrome and scleroderma or Raynaud’s syndroem and Sjögren’s syndrom respectively. The studies found provided data sufficient to estimate the prevalence of Raynaud’s syndrome. The statistical analysis was based on methods for a fixed effects meta-analysis and finite mixture model for proportions. Results: For scleroderma a pooled prevalence of 80.9% and 95% CI (0.78, 0.83) was obtained. A mixture model analysis found four latent classes. We identified a class with a very low prevalence of 11%, weighted with 0.15. On the other hand there is a class with a very high prevalence of 96%. Analysing the association with Sjögren’s syndrome, the pooled analysis leads to a prevalence of Raynaud’s syndrome of 32%, 95% CI(26.7%, 37.7%). A mixture model finds a solution with two latent classes. Here, 38% of the studies show a prevalence of 18.8% whereas 62% observe a prevalence of 38.3%. Conclusion: There is strong variability of studies reporting the prevalence of Raynaud’s syndrome in patients suffering from scleroderma or Sjögren’s syndrome. The available data are insufficient to perform a proper quantitative analysis of the association of Raynaud’s phenomenon with scleroderma or Sjögren’s syndrome. Properly planned and reported epidemiological studies are needed in order to perform a thorough quantitative analysis of risk factors for Raynaud’s syndrome.

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