scholarly journals Spindle Cell Metaplastic Breast Carcinoma with Leiomyoid Differentiation: A Case Report

Breast Care ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. 230-233 ◽  
Author(s):  
Claudius Conrad ◽  
Diane L. Miller ◽  
Christina Kaiser ◽  
Karl-Walter Jauch ◽  
Hanno Nieß ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Spindle Cell ◽  
Metaplastic Breast Carcinoma

scholarly journals Fibromatosis-like spindle-cell metaplastic carcinoma of the breast – a case report

2021 ◽  
Vol 19 (1) ◽  
pp. 98-101
Author(s):  
Michał Osuchowski ◽  
◽  
Dorota Bartusik-Aebisher ◽  
Ewa Kaznowska ◽  
David Aebisher ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Literature Review ◽  
Female Patient ◽  
Spindle Cell ◽  
Metaplastic Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Mesenchymal Tissue ◽  
Metaplastic Breast Carcinoma

Introduction. Metaplastic breast carcinoma is expressing epithelial and/or mesenchymal tissue within the same tumor. Aim. The aim of this study is to evaluate metaplastic breast carcinoma in a case report and literature review. Description of the case. The presented case desribes metaplastic carcinoma of the breast in 65 years old female patient. Conclusion. Fibromatosis-cell metaplastic carcinoma of the breast presents a particularly large diagnostic challenge. Malignant variants of this disease have been described in the literature.

Spindle Cell Metaplastic Breast Carcinoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Vithya Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Nazimah Ab Mumin ◽  
Kartini Rahmat
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Final Diagnosis ◽  
Spindle Cell Carcinoma ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Breast Lump ◽  
Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

scholarly journals Dermatofibrosarcoma protuberans – the use of neoadjuvant imatinib for treatment of an uncommon breast malignancy: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Matthew W. McGee ◽  
Sarag A. Boukhar ◽  
Varun Monga ◽  
Ronald Weigel ◽  
Sneha D. Phadke
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Spindle Cell ◽  
Treatment Options ◽  
Neoadjuvant Treatment ◽  
Breast Conservation ◽  
Dermatofibrosarcoma Protuberans ◽  
Molecular Testing ◽  
Correct Identification ◽  
Metaplastic Breast Carcinoma

Abstract Background Dermatofibrosarcoma protuberans is a rare soft tissue malignancy that, if left untreated, can be locally destructive and life-threatening. Dermatofibrosarcoma protuberans is uncommon in the breast, and the similarity of its morphologic features with other spindle cell malignancies can make correct identification difficult. Immunohistochemistry and molecular testing can aid in the correct diagnosis when there is diagnostic uncertainty. Imatinib, a selective tyrosine kinase inhibitor, has been used for adjuvant treatment of dermatofibrosarcoma protuberans following surgical resection. When used as a neoadjuvant treatment, imatinib offers the opportunity to decrease tumor size prior to surgery to lessen the chance for disfigurement. Case presentation We present the case of a Caucasian woman who was 46-year-old when she first noted a mass in her right breast in 2015; she was initially diagnosed as having metaplastic breast carcinoma. Mastectomy and systemic chemotherapy were planned; however, after review of pathology at a referral center, the diagnosis was changed to dermatofibrosarcoma protuberans. She was treated with 4 months of neoadjuvant imatinib with adequate tumor shrinkage to perform breast conservation. Conclusion This patient’s case stresses the importance of correctly diagnosing this rare breast tumor through the histopathologic appearance of dermatofibrosarcoma protuberans, molecular pathogenesis, and immunohistochemistry. These techniques can help differentiate dermatofibrosarcoma protuberans from metaplastic breast carcinoma and other spindle cell lesions of the breast. This is critical, as the treatment options for metaplastic breast carcinoma significantly differ from treatment options for dermatofibrosarcoma protuberans. This case describes the use of imatinib as a neoadjuvant option to reduce preoperative tumor size and improve surgical outcomes.

scholarly journals Metaplastic breast carcinoma “fibromatosis like”, associated with intraductal papilloma. Case report and literature review

2017 ◽  
Vol 9 ◽  
pp. 15-18 ◽  
Author(s):  
Ignacio Pinilla Pagnon ◽  
Belén Pérez Mies ◽  
Marco Tulio Martinez ◽  
Lourdes Peña Jaimes ◽  
Ana María Roldan Cabanillas ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Literature Review ◽  
Intraductal Papilloma ◽  
Metaplastic Breast Carcinoma

Metaplastic Breast Carcinoma: A Rare Entity

2019 ◽  
Vol 3 (1) ◽  
pp. 57-59
Author(s):  
Roshani Shrestha ◽  
Prakash Raj Neupane ◽  
Bandana Satyal
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Triple Negative ◽  
Invasive Breast Carcinoma ◽  
Rare Entity ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Lymphnode Metastasis ◽  
Rare Malignancy ◽  
Metaplastic Breast Carcinoma

Metaplastic Breast Carcinoma is a rare malignancy among invasive breast carcinoma. The patients usually present with large tumor size, axillary lymphnode metastasis and triple negative. The management of Metaplastic Breast carcinoma largely parallels that of Invasive Breast Carcinoma. In this case report, we found a case of metaplastic breast carcinoma with axillary lymphnode metastasis which is very rare.

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