Cardiorenal Syndrome: A Complex Series of Combined Heart/Kidney Disorders

2011 ◽  
pp. 33-45 ◽  
Author(s):  
Ching Yan Goh ◽  
Grazia Vizzi ◽  
Massimo De Cal ◽  
Claudio Ronco
Keyword(s):  
Cardiorenal Syndrome ◽  
Complex Series

Interim report on the structures at Howe, Stromness, Orkney

1984 ◽  
Vol 11 (1) ◽  
pp. 61-73 ◽  
Author(s):  
S P Carter ◽  
D Haigh ◽  
N R J Neil ◽  
Beverley Smith
Keyword(s):  
Iron Age ◽  
Interim Report ◽  
Complex Series ◽  
Settlement Site ◽  
Two Phases ◽  
Iron Working

Summary Excavations at Howe revealed a complex series of settlements which spanned the whole of the Iron Age period and were preceded by two phases of Neolithic activity. A probable stalled cairn was succeeded by a Maes Howe type chambered tomb which was later followed by enclosed settlements of which only scant remains survived. These settlements were replaced by a roundhouse with earth-house, built into the ruins of the chambered tomb. The roundhouse was surrounded by a contemporary defended settlement. Rebuilding led to the development of a broch structure and village. Partial collapse of tower brought about changes in the settlement, andalthougk some houses were maintained as domestic structures, others were rebuilt as iron-working sheds. The construction of smaller buildings and a later Iron Age or Pictish extended farmstead into rubble collapse accompanied a decline in the size of the settlement. The abandonment of the farmstead marked the end of Howe as a settlement site.

Repopulating Landscapes: Using Offence Data to Recreate Landscapes of Incarceration and Labour at the Port Arthur Penal Station, 1830–1877

2019 ◽  
Vol 13 (1-2) ◽  
pp. 155-181 ◽  
Author(s):  
Richard Tuffin ◽  
Martin Gibbs
Keyword(s):  
Labour Force ◽  
Spatial History ◽  
Complex Series ◽  
Industrial Landscape ◽  
Archaeological Landscape

For over half-a-century (1803–54), the Australian colony of Van Diemen's Land (Tasmania), played a key part in Britain's globe-spanning unfree diaspora. Today, a rich built and archaeological landscape, augmented by an exhaustive and relatively intact documentary archive, stand as eloquent markers to this convict legacy. As historical archaeologists, we have spent countless hours querying the physical and documentary residues in a bid to understand how the penological, social and economic imperatives of Britain and the colony shaped the management of convict labour. In particular, our task has centred upon the recovery of individual narratives – of both gaoler and gaoled – from such residues, moving away from a traditional focus on the broader outlines of the convict system. This paper illustrates how spatial history methodological processes have been used to relocate individual historic lives back into the convict industrial landscape of the Tasman Peninsula (Tasmania). Focusing on the male-only penal station of Port Arthur (1830–77), we will illustrate how we have reunited the physicality of past spaces and places, with the lives and labours of those who created and navigated them. Simple methodologies have been used to achieve this, designed with onward applicability in mind. A complex series of documents, convict conduct records, have been mined for spatial markers, allowing events and people to be relocated back into space. Through these processes of linkage and visualisation, we have been encouraged to ask further questions about the management of the unfree labour force and how this came to create the landscape we see today.

Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome

2014 ◽  
Vol 20 (14) ◽  
pp. 2448-2455 ◽  
Author(s):  
Seiji Ueda ◽  
Sho-ichi Yamagishi ◽  
Miyuki Yokoro ◽  
Seiya Okuda
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Cardiorenal Syndrome

PD-L1 Inhibitors for the Treatment of Prostate Cancer

2020 ◽  
Vol 21 (15) ◽  
pp. 1558-1565
Author(s):  
Matteo Santoni ◽  
Francesco Massari ◽  
Liang Cheng ◽  
Alessia Cimadamore ◽  
Marina Scarpelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
T Lymphocytes ◽  
Chronic Inflammation ◽  
Immune Cells ◽  
Response To Therapy ◽  
Complex Series

The carcinogenesis of prostate cancer (PCa) results from a complex series of events. Chronic inflammation and infections are crucial in this context. Infiltrating M2 type macrophages, as well as neutrophils and T lymphocytes, contribute to PCa development, progression and response to therapy. The preliminary findings on the efficacy of immunotherapy in patients with PCa were not encouraging. However, a series of studies investigating anti-PD-L1 agents such as Atezolizumab, Avelumab and Durvalumab used alone or in combination with other immunotherapies, chemotherapy or locoregional approaches are in course in this tumor. In this review, we illustrate the role of immune cells and PD-L1 expression during PCa carcinogenesis and progression, with a focus on ongoing clinical trials on anti-PD-L1 agents in this context.

RAAS Inhibition and Cardiorenal Syndrome

2015 ◽  
Vol 10 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Macaulay C. Onuigbo
Keyword(s):  
Cardiorenal Syndrome

scholarly journals Biomarkers in Cardiorenal Syndrome

2021 ◽  
Vol 10 (15) ◽  
pp. 3433
Author(s):  
Giovanni Goffredo ◽  
Roberta Barone ◽  
Vito Di Terlizzi ◽  
Michele Correale ◽  
Natale Daniele Brunetti ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiovascular Diseases ◽  
Clinical Manifestation ◽  
Kidney Diseases ◽  
Cardiorenal Syndrome ◽  
Clinical Usefulness

Cardiorenal syndrome is a clinical manifestation of the bidirectional interaction between the heart and kidney diseases. Over the last years, in patients with cardiovascular diseases, several biomarkers have been studied in order to better assess renal function as well as to identify patients prone to experiencing chronic or acute worsening of renal function. The aim of this review is to focus on the possible clinical usefulness of the most recent biomarkers in the setting of cardiorenal syndrome.

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