Prognostic Impact of Phosphorylated Mitogen-Activated Protein Kinase Expression in Patients with Metastatic Gastric Cancer

Oncology ◽  
2011 ◽  
Vol 80 (1-2) ◽  
pp. 130-134 ◽  
Author(s):  
Akin Atmaca ◽  
Claudia Pauligk ◽  
Kristina Steinmetz ◽  
Hans-Michael Altmannsberger ◽  
Elke Jäger ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Metastatic Gastric Cancer ◽  
Mitogen Activated Protein Kinase ◽  
Prognostic Impact ◽  
Mitogen Activated Protein ◽  
Kinase Expression

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport

2001 ◽  
Vol 90 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Mei Yu ◽  
Eva Blomstrand ◽  
Alexander V. Chibalin ◽  
Harriet Wallberg-Henriksson ◽  
Juleen R. Zierath ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Insulin Receptor ◽  
Insulin Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Signaling Cascade ◽  
Vastus Lateralis Muscle ◽  
Glut 4 ◽  
Mitogen Activated Protein ◽  
Kinase Expression

Vastus lateralis muscle biopsies were obtained from endurance-trained (running ∼50 km/wk) and untrained (no regular physical exercise) men, and the expression of an array of insulin-signaling intermediates was determined. Expression of insulin receptor and insulin receptor substrate-1 and -2 was decreased 44% ( P < 0.05), 57% ( P < 0.001), and 77% ( P < 0.001), respectively, in trained vs. untrained muscle. The downstream signaling target, Akt kinase, was not altered in trained subjects. Components of the mitogenic signaling cascade were also assessed. Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase expression was 190% greater ( P < 0.05), whereas p38 mitogen-activated protein kinase expression was 32% lower ( P < 0.05), in trained vs. untrained muscle. GLUT-4 protein expression was twofold higher ( P < 0.05), and the GLUT-4 vesicle-associated protein, the insulin-regulated aminopeptidase, was increased 4.7-fold ( P < 0.05) in trained muscle. In conclusion, the expression of proteins involved in signal transduction is altered in skeletal muscle from well-trained athletes. Downregulation of early components of the insulin-signaling cascade may occur in response to increased insulin sensitivity associated with endurance training.

scholarly journals Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma

2018 ◽  
Vol 6 (11) ◽  
pp. 1982-1985 ◽  
Author(s):  
Farhat Farhat ◽  
Elvita Rahmi Daulay ◽  
Jessy Chrestella ◽  
Rizalina Arwinati Asnir ◽  
Ashri Yudhistira ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Nasopharyngeal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Stage ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Keratinizing Squamous Cell Carcinoma ◽  
Kinase Expression

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma. AIM: The aim of this study is for observing and analysing the correlation of p38 mitogen-activated protein kinase expression in regards to nasopharyngeal carcinoma patient’s clinical stage. METHODS: This study involved 126 nasopharyngeal carcinoma patients admitted to Haji Adam Malik General Hospital. RESULTS: The result of this study indicates that nasopharyngeal carcinoma mostly found in the age group 41-60 years, male, non-keratinizing squamous cell carcinoma, and stage IV group. In immunohistochemistry evaluation, most of p38 mitogen-activated protein kinase overexpressed in non-keratinizing squamous cell carcinoma, T3-T4, N2-N3 and clinical stage III-IV. Spearman’s test for categorical correlation yield p-value of < 0.001. CONCLUSION: In conclusion, there is a significant correlation between p38 mitogen-activated protein kinase expression and the clinical stage of nasopharyngeal carcinoma.

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