Comparison of Efficacy between Continuous Hemodiafiltration with a PMMA High-Performance Membrane Dialyzer and a PAN Membrane Hemofilter in the Treatment of Septic Shock Patients with Acute Renal Failure

Author(s):  
Kenichi Matsuda ◽  
Takeshi Moriguchi ◽  
Norikazu Harii ◽  
Masahiko Yanagisawa ◽  
Daiki Harada ◽  
...  
Renal Failure ◽  
1993 ◽  
Vol 15 (5) ◽  
pp. 595-602 ◽  
Author(s):  
Rinaldo Bellomo ◽  
Darren Mansfield ◽  
Stuart Rumble ◽  
Jeremy Shapiro ◽  
Geoffrey Parkin ◽  
...  

ASAIO Journal ◽  
2001 ◽  
Vol 47 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Shigeyuki Sasaki ◽  
Satoshi Gando ◽  
Shigeaki Kobayashi ◽  
Satoshi Nanzaki ◽  
Toshiteru Ushitani ◽  
...  

Renal Failure ◽  
2002 ◽  
Vol 24 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Han Khim Tan ◽  
Rinaldo Bellomo ◽  
Debrah A. M’Pisi ◽  
Claudio Ronco

2001 ◽  
Vol 24 (4) ◽  
pp. 186-191 ◽  
Author(s):  
H.K. Tan ◽  
R. Bellomo ◽  
D.A. M'Pisi ◽  
C. Ronco

Background Achieving “adequacy of dialysis” includes the maintenance of normal serum phosphate concentrations and is an important therapeutic goal in the treatment of acute renal failure (ARF). It is unknown whether this goal is best achieved with intermittent or continuous renal replacement therapy. Methods We compared the effects of continuous veno-venous hemodiafiltration (CVVHDF) and intermittent hemodialysis (IHD) on serum phosphate concentrations using daily morning blood tests in 88 consecutive intensive care patients half of which were treated with IHD and half with CRRT. Results Mean patient age was 54 ± 14 years for IHD and 60 ± 14 years for CVVHDF (NS). However, patients who received CVVHDF were more critically ill (mean APACHE II scores: 24.4 ± 5.1 for IHD vs. 29.2 ± 5.7 for CVVHDF, p<0.003). Before treatment, the serum phosphate concentration was 2.04 ± 0.16 mmoll L for IHD and 1.96 ± 0.17 mmoll L for CVVHDF (NS), with abnormal values in 79.4% of IHD patients and in 64.8% of CVVHDF patients (NS). During treatment, CVVHDF induced a greater reduction in serum phosphate (p=0.02) during the first 48 hours and conferred superior subsequent control of hyperphosphatemia (achieved in 64.6% of observations during CVVHDF vs. 41.8% during IHD; p<0.0001). The serum phosphate concentration was also more likely to be within the normal range during CVVHDF (55.3% vs.36.2%; p<0.0001). There was a trend toward more frequent hypophosphatemia (9.3% vs. 5.6%; P<0.1) during CVVHDF. Conclusions Abnormal serum phosphate concentrations are frequent in ARF patients before and during renal replacement, however, normalization of phosphatemia is achieved more frequently with CVVHDF.


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