Suspicion of Drug-Drug Interaction between High-Dose Methotrexate and Proton Pump Inhibitors: A Case Report – Should the Practice Be Changed?

Chemotherapy ◽  
2011 ◽  
Vol 57 (3) ◽  
pp. 225-229 ◽  
Author(s):  
F. Ranchon ◽  
N. Vantard ◽  
A. Gouraud ◽  
V. Schwiertz ◽  
E. Franchon ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Case Report ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
Drug Drug Interaction

scholarly journals Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy

2009 ◽  
Vol 67 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Kunihiro Suzuki ◽  
Kosuke Doki ◽  
Masato Homma ◽  
Hirofumi Tamaki ◽  
Satoko Hori ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Methotrexate Therapy ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

Tu1820 The Impact of Co-Administration of Proton Pump Inhibitors on Plasma Methotrexate Clearance in High-Dose Methotrexate Therapy

2013 ◽  
Vol 144 (5) ◽  
pp. S-854-S-855 ◽  
Author(s):  
Koh Imbe ◽  
Naoyoshi Nagata ◽  
Chizu Yokoi ◽  
Kazuhiro Watanabe ◽  
Etsuko Yokota ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Methotrexate Therapy ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
The Impact

A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy

2019 ◽  
Vol 54 (1) ◽  
pp. 29-35
Author(s):  
Junko Ishizaki ◽  
Chihiro Nakano ◽  
Kana Kitagawa ◽  
Yukio Suga ◽  
Yoshimichi Sai
Keyword(s):  
Drug Interaction ◽  
Multiple Logistic Regression Analysis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
High Serum ◽  
Screening Tests ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
Drug Drug Interaction

Background: High-dose methotrexate (HD-MTX) therapy is widely implemented for leukemia, osteosarcoma, and lymphoma. Although various measures have been taken to avoid toxicity from high serum MTX concentrations, there are many cases of delayed elimination of MTX. Objective: We suspected that delayed elimination of serum MTX was caused by unknown interactions between MTX and concomitant drugs. Methods: Concerning concomitant drugs in the case of delayed elimination of MTX, we performed screening tests in 35 patients who had undergone HD-MTX therapy. We then investigated the risk factors for delayed MTX elimination in 94 patients with leukemia, lymphoma, or osteosarcoma retrospectively. Results: The percentages of concomitant use of Stronger Neo-Minophagen C (SNMC), a glycyrrhizin preparation, and vincristine were higher in the delayed group. The percentage of delayed MTX elimination in patients receiving HD-MTX therapy was 41%. Multiple logistic regression analysis revealed that the concomitant use of SNMC solely was a significant risk factor for delayed MTX (odds ratio = 12.20; 95% CI = 1.06-139.84). Conclusion and Relevance: Concomitant use of SNMC was shown to be related to delayed elimination of serum MTX, and our results suggested a previously unknown drug-drug interaction between MTX and SNMC.

The potential drug-drug interaction between proton pump inhibitors and warfarin

2015 ◽  
Vol 24 (12) ◽  
pp. 1337-1340 ◽  
Author(s):  
Daniel Pilsgaard Henriksen ◽  
Tore Bjerregaard Stage ◽  
Morten Rix Hansen ◽  
Lotte Rasmussen ◽  
Per Damkier ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Potential Drug ◽  
Drug Drug Interaction

Accidental shortening time of high dose methotrexate infusion: case report and literature review

2013 ◽  
Vol 71 (2) ◽  
pp. 219-222 ◽  
Author(s):  
Rim Charfi ◽  
Issam Salouage ◽  
Sameh Trabelsi ◽  
Mohamed Zarrouk ◽  
Emna Gaïes ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

In vitro and in vivo evaluation of drug-drug interaction between dabigatran and proton pump inhibitors

2015 ◽  
Vol 29 (6) ◽  
pp. 604-614 ◽  
Author(s):  
Edouard Ollier ◽  
Sophie Hodin ◽  
Thierry Basset ◽  
Sandrine Accassat ◽  
Laurent Bertoletti ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
In Vivo Evaluation ◽  
Drug Drug Interaction

scholarly journals Accumulating Evidence for a Drug–Drug Interaction Between Methotrexate and Proton Pump Inhibitors

2012 ◽  
Vol 17 (4) ◽  
pp. 550-554 ◽  
Author(s):  
Shewit Bezabeh ◽  
Ann Corken Mackey ◽  
Paul Kluetz ◽  
Dilara Jappar ◽  
Joyce Korvick
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Drug Drug Interaction
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