Fine Needle Aspiration of Langerhans Cell Histiocytosis of the Lymph Nodes

2002 ◽  
Vol 46 (4) ◽  
pp. 753-756 ◽  
Author(s):  
Perikala V. Kumar ◽  
Abdullah Mousavi ◽  
Mehran Karimi ◽  
Gholam Reza Bedayat
Keyword(s):  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Langerhans Cell Histiocytosis ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Fine Needle

scholarly journals Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration

2015 ◽  
Vol 32 (4) ◽  
pp. 244 ◽  
Author(s):  
Reetu Kundu ◽  
Uma Handa ◽  
RajpalSingh Punia ◽  
Harsh Mohan
Keyword(s):  
Fine Needle Aspiration ◽  
Langerhans Cell Histiocytosis ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Fine Needle

Fine Needle Aspiration of Langerhans Cell Histiocytosis: A Cytopathologic Study of 37 Cases

2017 ◽  
Vol 61 (2) ◽  
pp. 96-102 ◽  
Author(s):  
Jen-Fan Hang ◽  
Momin T. Siddiqui ◽  
Syed Z. Ali
Keyword(s):  
Fine Needle Aspiration ◽  
Langerhans Cell Histiocytosis ◽  
S100 Protein ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
University Hospital ◽  
Johns Hopkins Hospital ◽  
Fine Needle ◽  
Children And Young Adults ◽  
Immunohistochemical Stains

Objective: Langerhans cell histiocytosis (LCH) is an uncommon neoplasm of dendritic cells and predominantly occurs in children and young adults. The study aims to evaluate cytopathologic features and current diagnostic concepts in a large series of LCH on fine needle aspiration (FNA). Study Design: We retrospectively searched the pathology archives of The Johns Hopkins Hospital (JHH) and Emory University Hospital (EUH) to identify all FNA cases diagnosed as LCH in a period of 21 years. Cytologic material and immunohistochemical stains were reviewed. Results: A total of 37 LCH patients (26 from JHH and 11 from EUH) with FNA diagnoses were identified. The sites of LCH included bone in 28, soft tissue of head and neck in 6, and lymph nodes in 3. Thirty-one patients (84%) were diagnosed as LCH, 4 (11%) had a descriptive diagnosis suggesting scant cellularity with epithelioid/histiocyte-like cells and mixed inflammation, and 2 (5%) were non-diagnostic due to insufficient cellularity. Immunohistochemical stains were performed on cell block sections in 26 cases, showing 24 of 24 (100%) positive for CD1a, 22 of 23 (96%) positive for S100-protein, and 3 of 3 (100%) positive for CD68. Conclusions: LCH can be accurately diagnosed in FNA based on the characteristic cytomorphology and selected immunohistochemistry. Diagnosis may be difficult in cases with scant or insufficient cellular material.

scholarly journals Diagnosis of Langerhans Cell Histiocytosis on Fine Needle Aspiration Cytology: A Case Report and Review of the Cytology Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Neeta Kumar ◽  
Shahin Sayed ◽  
Sudhir Vinayak
Keyword(s):  
Case Report ◽  
Fine Needle Aspiration ◽  
Langerhans Cell Histiocytosis ◽  
Needle Aspiration ◽  
Accurate Diagnosis ◽  
Langerhans Cell ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Cytological Features ◽  
Needle Aspiration Cytology

A case of multifocal Langerhans cell histiocytosis in a two-year-old child is presented where fine needle aspiration was helpful in achieving a rapid and accurate diagnosis in an appropriate clinical and radiological setting. This can avoid unnecessary biopsy and guide the management especially where access to histopathology is limited. The highly characteristic common and rare cytological features are highlighted with focus on differential diagnoses and causes of pitfalls.

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