Effects of Long-Acting Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder: A Study with Paired-Pulse Transcranial Magnetic Stimulation

2011 ◽  
Vol 64 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Marc K.F. Schneider ◽  
Wolfgang Retz ◽  
Gavril Gougleris ◽  
Willem M.A. Verhoeven ◽  
Joke H.M. Tulen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Transcranial Magnetic Stimulation ◽  
Attention Deficit ◽  
Magnetic Stimulation ◽  
Paired Pulse ◽  
Hyperactivity Disorder ◽  
Long Acting

scholarly journals Motor cortex modulation and reward in children with attention-deficit/hyperactivity disorder

2021 ◽  
Author(s):  
Jordan A Detrick ◽  
Caroline Zink ◽  
Keri Shiels Rosch ◽  
Paul S Horn ◽  
David A Huddleston ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Transcranial Magnetic Stimulation ◽  
Attention Deficit ◽  
Magnetic Stimulation ◽  
Evoked Potential ◽  
Short Interval ◽  
Motor Evoked Potential ◽  
Cortical Inhibition ◽  
Children With Adhd ◽  
Hyperactivity Disorder

Abstract Attention-Deficit/Hyperactivity Disorder, the most prevalent developmental disorder in childhood, is a biologically heterogenous condition characterized by impaired attention and impulse control as well as motoric hyperactivity and anomalous motor skill development. Neuropsychological testing often demonstrates impairments in motivation and reward-related decision making in ADHD, believed to indicate dysfunction of the dopamine reward pathway. Development of reliable, non-invasive, easily obtained, and quantitative biomarkers correlating with the presence and severity of clinical symptoms and impaired domains of function could aid in identifying meaningful ADHD subgroups and targeting appropriate treatments. To this end, 55 (37 male) 8–12-year-old children with ADHD and 50 (32 male) age-matched, typically-developing controls were enrolled in a transcranial magnetic stimulation protocol- used previously to quantify cortical disinhibition in both ADHD and Parkinson’s Disease- with a child-friendly reward motivation task. The primary outcomes were reward task-induced changes in short interval cortical inhibition and up-modulation of motor evoked potential amplitudes, evaluated using mixed model, repeated measure regression. Our results show that both reward cues and reward receipt reduce short-interval cortical inhibition, and that baseline differences by diagnosis (less inhibition in ADHD) were no longer present when reward was cued or received. Similarly, both reward cues and reward receipt up-modulated motor evoked potential amplitudes, but, differentiating the two groups, this Task-Related-Up-Modulation was decreased in children with ADHD. Further, more severe hyperactive/impulsive symptoms correlated significantly with less up-modulation with success in obtaining reward. These results suggest that in children with ADHD, short interval cortical inhibition may reflect baseline deficiencies as well as processes that normalize performance under rewarded conditions. Task-Related-Up-Modulation may reflect general hypo-responsiveness in ADHD to both reward cue and, especially in more hyperactive/impulsive children, to successful reward receipt. These findings support transcranial magnetic stimulation evoked cortical inhibition and task-induced excitability as biomarkers of clinically relevant domains of dysfunction in childhood ADHD.

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