Post-Parathyroidectomy Parathyroid Hormone Levels: The Impact on Patient Survival – A Single-Centre Study in a Stage 5 Chronic Kidney Disease Population

2011 ◽  
Vol 119 (2) ◽  
pp. c113-c120 ◽  
Author(s):  
James Fotheringham ◽  
Saba P. Balasubramanian ◽  
Barney Harrison ◽  
Martin Wilkie
2020 ◽  
Vol 35 (2) ◽  
pp. 346-356
Author(s):  
Nicole Bischof ◽  
Caroline Wehmeier ◽  
Michael Dickenmann ◽  
Patricia Hirt-Minkowski ◽  
Patrizia Amico ◽  
...  

Abstract Background Cytomegalovirus (CMV) serostatus and CMV replication are considered as risk factors for inferior graft and patient survival after renal transplantation, but long-term outcome data are limited. The aim of this retrospective single-centre study was to investigate the impact of CMV serostatus and CMV replication/disease on long-term outcomes in a well-defined cohort managed by a standardized CMV prevention/treatment protocol. Methods We investigated 599 consecutive kidney transplantations having a CMV prevention protocol consisting of either prophylaxis (D+/R− and R+ with ATG induction) or screening/deferred therapy (R+ without ATG induction). Patients were grouped according to CMV serostatus [high risk (D+/R−): n = 122; intermediate risk (R+): n = 306; low risk (D−/R−): n = 171] and occurrence of CMV replication/disease (no CMV replication: n = 419; asymptomatic CMV replication: n = 110; CMV syndrome: n = 39; tissue-invasive CMV disease: n = 31). The median follow-up time was 6.5 years. Results Graft and patient survival were not different among the three CMV serostatus groups as well as the four CMV replication/disease groups (P ≥ 0.44). Eighty-seven patients died, 17 due to infections (21%), but none was attributable to CMV. The overall hospitalization incidence for CMV-related infection was 3% (17/599 patients). The incidence of clinical and (sub)clinical rejection was similar among the groups (P ≥ 0.17). In a multivariate Cox proportional hazard model, neither CMV serostatus, nor CMV replication, nor CMV disease were independent predictors for patient death or graft failure, respectively. Conclusions This retrospective single-centre study suggests that the negative impact of CMV infection on long-term patient and allograft survival as well as on allograft rejection can be largely eliminated with current diagnostic/therapeutic management.


2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Anastasia Garoufi ◽  
Styliani Drapanioti ◽  
Antonios Marmarinos ◽  
Varvara Askiti ◽  
Andromachi J. Mitsioni ◽  
...  

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Elliot K. Tannor ◽  
Betty R. Norman ◽  
Kwame K. Adusei ◽  
Fred S. Sarfo ◽  
Mogamat R. Davids ◽  
...  

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