Deep Brain Stimulation of the Pedunculopontine Nucleus in a Patient with Freezing of Gait

2011 ◽  
Vol 89 (4) ◽  
pp. 214-219 ◽  
Author(s):  
Feridun Acar ◽  
Göksemin Acar ◽  
Levent Sinan Bir ◽  
Bengi Gedik ◽  
Attila Oğuzhanoğlu
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Freezing Of Gait ◽  
Pedunculopontine Nucleus ◽  
Deep Brain ◽  
Stimulation Of

Urinary incontinence following deep brain stimulation of the pedunculopontine nucleus

2011 ◽  
Vol 153 (12) ◽  
pp. 2357-2360 ◽  
Author(s):  
Iciar Aviles-Olmos ◽  
Thomas Foltynie ◽  
Jalesh Panicker ◽  
Dorothy Cowie ◽  
Patricia Limousin ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Pedunculopontine Nucleus ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Efficacy and Safety of Pedunculopontine Nuclei (PPN) Deep Brain Stimulation in the Treatment of Gait Disorders: A Meta-Analysis of Clinical Studies

2015 ◽  
Vol 43 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Laleh Golestanirad ◽  
Behzad Elahi ◽  
Simon J. Graham ◽  
Sunit Das ◽  
Lawrence L. Wald
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Freezing Of Gait ◽  
Pedunculopontine Nucleus ◽  
Postural Instability ◽  
Internal Globus Pallidus ◽  
Motor Abnormalities ◽  
Deep Brain

AbstractBackground: Pedunculopontine nucleus (PPN) has complex reciprocal connections with basal ganglia, especially with internal globus pallidus and substantia nigra, and it has been postulated that PPN stimulation may improve gait instability and freezing of gait. In this meta-analysis, we will assess the evidence for PPN deep brain stimulation in treatment of gait and motor abnormalities especially focusing on Parkinson disease patients. Methods: PubMed and Scopus electronic databases were searched for related studies published before February 2014. Medline (1966-2014), Embase (1974-2010), CINAHL, Web of Science, Scopus bibliographic, and Google Scholar databases (1960-2014) were also searched for studies investigating effect of PPN deep brain stimulation in treatment of postural and postural instability and total of ten studies met the inclusion criteria for this analysis. Results: Our findings showed a significant improvement in postural instability (p<0.001) and motor symptoms of Parkinson disease on and off medications (p<0.05), but failed to show improvement in freezing of gait. Conclusions: Despite significant improvement in postural instability observed in included studies, evidence from current literature is not sufficient to generalize these findings to the majority of patients.

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