Cerebral Ischemia Related to Globus Pallidus Internus Stimulation for Cervical Dystonia

2011 ◽  
Vol 89 (4) ◽  
pp. 201-204 ◽  
Author(s):  
Dong Wan Kang ◽  
Hae Yu Kim ◽  
Jin Woo Chang
Keyword(s):  
Cerebral Ischemia ◽  
Globus Pallidus ◽  
Cervical Dystonia ◽  
Globus Pallidus Internus

Location of Active Contacts in Patients with Primary Dystonia Treated with Globus Pallidus Deep Brain Stimulation

2008 ◽  
Vol 62 (suppl_1) ◽  
pp. ONS217-ONS225 ◽  
Author(s):  
Clement Hamani ◽  
Elena Moro ◽  
Cindy Zadikoff ◽  
Yu-Yan Poon ◽  
Andres M. Lozano
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Cervical Dystonia ◽  
Rating Scale ◽  
Globus Pallidus Internus ◽  
Generalized Dystonia ◽  
Deep Brain

Abstract Objective: Deep brain stimulation of the globus pallidus internus has been used for the treatment of various forms of dystonia, but the factors influencing postoperative outcomes remain unknown. We compared the location of the contacts being used for stimulation (active contacts) in patients with cervical dystonia, generalized dystonia, and Parkinson's disease and correlated the results with clinical outcome. Methods: Postoperative magnetic resonance scans of 13 patients with cervical dystonia, six patients with generalized dystonia, and five patients with Parkinson's disease who underwent globus pallidus internus deep brain stimulation were analyzed. We assessed the location of the active contacts relative to the midcommisural point and in relation to the anteroposterior and mediolateral boundaries of the pallidum. Postoperative outcome was measured with the Toronto Western Spasmodic Torticollis Rating Scale (for cervical dystonia) and the Burke-Fahn-Marsden Dystonia Rating Scale (for generalized dystonia) during the last follow-up. Results: We found that the location of the active contacts relative to the midcom-misural point and the internal boundaries of the pallidum was similar across the groups. In our series, the contacts used for stimulation were clustered in the posterolateral region of the pallidum. Within that region, we found no correlation between the location of the contacts and postoperative outcome. Conclusion: The location of the active contacts used for globus pallidus internus deep brain stimulation was similar in patients with cervical dystonia, generalized dystonia, and Parkinson's disease.

scholarly journals Neuronal Firing Rates and Patterns in the Globus Pallidus Internus of Patients With Cervical Dystonia Differ From Those With Parkinson's Disease

2007 ◽  
Vol 98 (2) ◽  
pp. 720-729 ◽  
Author(s):  
Joyce K. H. Tang ◽  
Elena Moro ◽  
Neil Mahant ◽  
William D. Hutchison ◽  
Anthony E. Lang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Globus Pallidus ◽  
Cervical Dystonia ◽  
Neuronal Firing ◽  
Globus Pallidus Internus ◽  
Motor Symptoms ◽  
Firing Rates ◽  
Irregular Pattern

Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the differing motor symptoms in CD and PD may arise from a decreased GPi output in CD and elevation of output in PD. To test this hypothesis, extracellular recordings of GPi neuronal activity were obtained during stereotactic surgery for the implantation of DBS electrodes in seven idiopathic CD and 14 PD patients. The mean GPi neuronal firing rate recorded from CD patients was lower than that in PD patients ( P < 0.001; means ± SE: 71.4 ± 2.2 and 91.7 ± 3.0 Hz, respectively). Furthermore, GPi neurons fired in a more irregular pattern consisting of more frequent and longer pauses in CD compared with PD patients. When comparisons were done based on locations of recordings, these differences in firing rates and patterns were limited to the ventral portion of the GPi. In contrast, no difference in firing rate or pattern was observed in the globus pallidus externus between the two groups. These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders.

Bilateral stimulation of globus pallidus internus for treatment of cervical dystonia

The Lancet ◽  
1999 ◽  
Vol 354 (9181) ◽  
pp. 837-838 ◽  
Author(s):  
Joachim K Krauss ◽  
Thomas Pohle ◽  
Sabine Weber ◽  
Christoph Ozdoba ◽  
Jean-Marc Burgunder
Keyword(s):  
Globus Pallidus ◽  
Cervical Dystonia ◽  
Globus Pallidus Internus ◽  
Bilateral Stimulation ◽  
Stimulation Of

scholarly journals Early internal capsule infarction following globus pallidus internus lesioning for cervical dystonia

2021 ◽  
pp. 106422
Author(s):  
Pritam Gurung ◽  
Resha Shrestha ◽  
Sambardhan Dabadi ◽  
Raju Raj Dhungel ◽  
Bishal Shrestha ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Cervical Dystonia ◽  
Internal Capsule ◽  
Globus Pallidus Internus
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