Evaluation of Nipple Discharge Cytology and Diagnostic Value of Red Blood Cells in Cases with Negative Cytology

2010 ◽  
Vol 54 (4) ◽  
pp. 560-562 ◽  
Author(s):  
Hesham El-Daly ◽  
Mihir Gudi
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Nipple Discharge ◽  
Diagnostic Value

scholarly journals P2-239: POTENTIAL DIAGNOSTIC VALUE OF RED BLOOD CELLS α-SYNUCLEIN HETEROAGGREGATES IN ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P672-P673
Author(s):  
Filippo Baldacci ◽  
Simona Daniele ◽  
Rebecca Piccarducci ◽  
Linda Giampietri ◽  
Deborah Giampietri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Diagnostic Value

scholarly journals Association between blood counts-related parameters and disease activity in patients with rheumatoid arthritis

2020 ◽  
Author(s):  
Li Xue ◽  
Li Tao ◽  
Haifeng Sun ◽  
Yan Wang ◽  
Yanping Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Red Blood Cells ◽  
Roc Curve ◽  
Blood Cells ◽  
Critical Role ◽  
Diagnostic Value ◽  
Inflammatory Factor ◽  
Logistical Regression ◽  
Inactive Group

Background: Erythrocytes and platelets have been demonstrated to play a critical role in inflammatory processes. However, little is known about the diagnostic value of these indices in RA patients. The aim of this study was to evaluate the clinical significance of blood counts-related parameters such as counts of red blood cells (RBCs) and platelets (PLTs), hemoglobin (Hb), red blood cells-platelet ratio (RPR) and hemoglobin-platelet ratio (HPR) in rheumatoid arthritis (RA) and their association with disease activity. Methods: Clinical and laboratory data from 178 RA patients and 164 healthy controls were collected and analyzed. RA patients were divided into inactive group and active group according to disease activity score in 28 joints based on C-reactive protein (DAS28-CRP). The relationship between blood RBC, Hb, PLT, RPR and HPR and DAS28-CRP was detected by Spearman correlation method. Receiver operating characteristic (ROC) curve was used to assess the diagnostic value of these parameters. The predictive role of these indices for RA disease activity was evaluated by logistical regression analysis. Results: Active RA patients exhibited lower levels of blood RBC counts, Hb, HCT, RPR and HPR but significantly higher level of PLT counts compared with those in inactive groups (P < 0.01). Spearman analysis showed that blood RBC counts, HCT, RPR and HPR were negatively but PLT counts were positively related with DAS28-CRP (P < 0.001) in RA. ROC curve analysis revealed that the AUC of RBC and Hb was higher than that of ESR, RF and CCP for distinguishing active RA from inactive group. Logistical regression analyses showed that PLT is an independent predictor for RA disease activity. Conclusion: Blood RBC counts, Hb, RPR and HPR were negatively but PLT counts were positively related with RA disease activity. Blood PLT may act as a novel inflammatory factor for predicting disease activity in RA.

Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer’s Disease

2019 ◽  
Vol 56 (9) ◽  
pp. 6451-6459 ◽  
Author(s):  
Filippo Baldacci ◽  
Simona Daniele ◽  
Rebecca Piccarducci ◽  
Linda Giampietri ◽  
Deborah Pietrobono ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Diagnostic Value

Osmotic fragility of red blood cells – a review of diagnostic methods

2015 ◽  
Vol 51 (3) ◽  
pp. 229-234
Author(s):  
Agata Zgodzińska ◽  
Olga Ciepiela
Keyword(s):  
Red Blood Cells ◽  
Test Performance ◽  
Blood Cells ◽  
Osmotic Fragility ◽  
Diagnostic Value ◽  
Diagnostic Methods ◽  
Hypotonic Solution ◽  
Laboratory Practice ◽  
Diagnostic Screening ◽  
Flow Cytometric

Osmotic Fragility Test (OFT) is widely considered as a sensitive indicator of red blood cells sensitivity to the hypotonic solution. Traditional osmotic fragility test (Dacie and Lewis) is time and work-consuming, and need relatively large minimum volume of peripheral blood for proper test performance. It does not belong to the most popular tests in a daily laboratory practice. The purpose of this article is to underline the diagnostic value of the Osmotic Fragility Test as well as present the latest methods that improves the traditional technique, such as Acidified Glycerol Lysis Test (AGLT 50), Pink Test, or Flow Cytometric Osmotic Fragility Test (FCM OF Test). Perhaps a new, fresh view at the issue in the nearest future will contribute to reconsider the osmotic fragility test for routine diagnostic screening of red blood cell disorders in children and adults.

Hemoglobin crystals of the red blood cells in the human renal cortex: electron microscopic observations of the renal lithiasis

1978 ◽  
Vol 36 (2) ◽  
pp. 480-481
Author(s):  
Kosuke Ueda ◽  
Hiroto Washida ◽  
Nakazo Watari
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Renal Cortex ◽  
Uranyl Acetate ◽  
Osmic Acid ◽  
Renal Lithiasis ◽  
Electron Microscopic ◽  
Hemoglobin C ◽  
First Case ◽  
Ultrathin Sections

IntroductionHemoglobin crystals in the red blood cells were electronmicroscopically reported by Fawcett in the cat myocardium. In the human, Lessin revealed crystal-containing cells in the periphral blood of hemoglobin C disease patients. We found the hemoglobin crystals and its agglutination in the erythrocytes in the renal cortex of the human renal lithiasis, and these patients had no hematological abnormalities or other diseases out of the renal lithiasis. Hemoglobin crystals in the human erythrocytes were confirmed to be the first case in the kidney.Material and MethodsTen cases of the human renal biopsies were performed on the operations of the seven pyelolithotomies and three ureterolithotomies. The each specimens were primarily fixed in cacodylate buffered 3. 0% glutaraldehyde and post fixed in osmic acid, dehydrated in graded concentrations of ethanol, and then embedded in Epon 812. Ultrathin sections, cut on LKB microtome, were doubly stained with uranyl acetate and lead citrate.

Densitometric Identification of Primitive Erythroblasts After Reaction With Diaminobenzidine

1973 ◽  
Vol 31 ◽  
pp. 328-329
Author(s):  
John A. Trotter
Keyword(s):  
Red Blood Cells ◽  
Analytical Method ◽  
Blood Cells ◽  
Guinea Pigs ◽  
Specific Protein ◽  
Visual Examination ◽  
Hemoglobin Synthesis ◽  
Peroxidatic Activity ◽  
Small Density

Hemoglobin is the specific protein of red blood cells. Those cells in which hemoglobin synthesis is initiated are the earliest cells that can presently be considered to be committed to erythropoiesis. In order to identify such early cells electron microscopically, we have made use of the peroxidatic activity of hemoglobin by reacting the marrow of erythropoietically stimulated guinea pigs with diaminobenzidine (DAB). The reaction product appeared as a diffuse and amorphous electron opacity throughout the cytoplasm of reactive cells. The detection of small density increases of such a diffuse nature required an analytical method more sensitive and reliable than the visual examination of micrographs. A procedure was therefore devised for the evaluation of micrographs (negatives) with a densitometer (Weston Photographic Analyzer).

Scanning electron microscopy of erythrophagocytosis by Entamoeba histolytica trophozoites

1992 ◽  
Vol 50 (1) ◽  
pp. 880-881
Author(s):  
Victor Tsutsumi ◽  
Adolfo Martinez-Palomo ◽  
Kyuichi Tanikawa
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Red Blood Cells ◽  
Entamoeba Histolytica ◽  
Causative Agent ◽  
Blood Cells ◽  
Protozoan Parasite ◽  
Complex Phenomenon ◽  
Great Capacity ◽  
Scanning Electron

The protozoan parasite Entamoeba histolytica is the causative agent of amebiasis in man. The trophozoite or motile form is a highly dynamic and pleomorphic cell with a great capacity to destroy tissues. Moreover, the parasite has the singular ability to phagocytize a variety of different live or death cells. Phagocytosis of red blood cells by E. histolytica trophozoites is a complex phenomenon related with amebic pathogenicity and nutrition.

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