Effects of Repeated Stress on Distal Airway Inflammation, Remodeling and Mechanics in an Animal Model of Chronic Airway Inflammation

2012 ◽  
Vol 19 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Edna A. Leick ◽  
Fabiana G. Reis ◽  
Flávia Alves Honorio-Neves ◽  
Rafael Almeida-Reis ◽  
Carla M. Prado ◽  
...  
Keyword(s):  
Animal Model ◽  
Airway Inflammation ◽  
Repeated Stress ◽  
Distal Airway ◽  
Chronic Airway

scholarly journals Molecular and Cellular Mechanisms Responsible for Beneficial Effects of Mesenchymal Stem Cell-Derived Product “Exo-d-MAPPS” in Attenuation of Chronic Airway Inflammation

2020 ◽  
Vol 2020 ◽  
pp. 1-15 ◽  
Author(s):  
Carl Randall Harrell ◽  
Dragica Miloradovic ◽  
Ruxana Sadikot ◽  
Crissy Fellabaum ◽  
Bojana Simovic Markovic ◽  
...  
Keyword(s):  
Animal Model ◽  
Airway Inflammation ◽  
Natural Killer ◽  
Inflammatory Cytokines ◽  
Therapeutic Agent ◽  
Alveolar Epithelial Cells ◽  
Chronic Obstructive ◽  
Cell Based Therapy ◽  
Copd Patients ◽  
Chronic Airway

Mesenchymal stem cells (MSCs), due to their potential for differentiation into alveolar epithelial cells and their immunosuppressive characteristics, are considered a new therapeutic agent in cell-based therapy of inflammatory lung disorders, including chronic obstructive pulmonary disease (COPD). Since most of the MSC-mediated beneficent effects were the consequence of their paracrine action, herewith, we investigated the effects of a newly designed MSC-derived product “Exosome-derived Multiple Allogeneic Protein Paracrine Signaling (Exo-d-MAPPS)” in the attenuation of chronic airway inflammation by using an animal model of COPD (induced by chronic exposure to cigarette smoke (CS)) and clinical data obtained from Exo-d-MAPPS-treated COPD patients. Exo-d-MAPPS contains a high concentration of immunomodulatory factors which are capable of attenuating chronic airway inflammation, including soluble TNF receptors I and II, IL-1 receptor antagonist, and soluble receptor for advanced glycation end products. Accordingly, Exo-d-MAPPS significantly improved respiratory function, downregulated serum levels of inflammatory cytokines (TNF-α, IL-1β, IL-12, and IFN-γ), increased serum concentration of immunosuppressive IL-10, and attenuated chronic airway inflammation in CS-exposed mice. The cellular makeup of the lungs revealed that Exo-d-MAPPS treatment attenuated the production of inflammatory cytokines in lung-infiltrated macrophages, neutrophils, and natural killer and natural killer T cells and alleviated the antigen-presenting properties of lung-infiltrated macrophages and dendritic cells (DCs). Additionally, Exo-d-MAPPS promoted the expansion of immunosuppressive IL-10-producing alternatively activated macrophages, regulatory DCs, and CD4+FoxP3+T regulatory cells in inflamed lungs which resulted in the attenuation of chronic airway inflammation. In a similar manner, as it was observed in an animal model, Exo-d-MAPPS treatment significantly improved the pulmonary status and quality of life of COPD patients. Importantly, Exo-d-MAPPS was well tolerated since none of the 30 COPD patients reported any adverse effects after Exo-d-MAPPS administration. In summing up, we believe that Exo-d-MAPPS could be considered a potentially new therapeutic agent in the treatment of chronic inflammatory lung diseases whose efficacy should be further explored in large clinical trials.

scholarly journals The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway

2020 ◽  
Author(s):  
Yingjie Zhu ◽  
Jingjing Luo ◽  
You Xu ◽  
Shucheng Hua ◽  
Dan Li ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Active Compound ◽  
Protective Role ◽  
Asthma Model ◽  
Common Illnesses ◽  
Murine Asthma Model ◽  
Chronic Airway

Asthma is one of the most common illnesses associated with chronic airway inflammation; however, there are currently no effective therapies apart from glucocorticoids. Zingerone (ZIN), an active compound isolated from...

scholarly journals Role of Neuro‐immune Interactions in a Cigarette Smoke‐induced Chronic Airway Inflammation Mouse Model

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Kata Csekő ◽  
István Szitter ◽  
Zsófia Hajna ◽  
Krisztián Elekes ◽  
Ágnes Kemény ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Cigarette Smoke ◽  
Chronic Airway

scholarly journals IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation

2019 ◽  
Vol 144 (6) ◽  
pp. 1624-1637.e10 ◽  
Author(s):  
Jeanne Allinne ◽  
George Scott ◽  
Wei Keat Lim ◽  
Dylan Birchard ◽  
Jonas S. Erjefält ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Chronic Airway

scholarly journals Angiogenesis in Mice with Chronic Airway Inflammation

1998 ◽  
Vol 153 (4) ◽  
pp. 1099-1112 ◽  
Author(s):  
Gavin Thurston ◽  
Thomas J. Murphy ◽  
Peter Baluk ◽  
J. Russell Lindsey ◽  
Donald M. McDonald
Keyword(s):  
Airway Inflammation ◽  
Chronic Airway

Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes

2007 ◽  
Vol 293 (3) ◽  
pp. L730-L739 ◽  
Author(s):  
Jill R. Johnson ◽  
Filip K. Swirski ◽  
Beata U. Gajewska ◽  
Ryan E. Wiley ◽  
Ramzi Fattouh ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Inflammatory Responses ◽  
Airway Remodeling ◽  
Bronchial Hyperresponsiveness ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Th Cell ◽  
And Function ◽  
Deficient Mice ◽  
Chronic Airway

Asthma is a chronic airway inflammatory disease that encompasses three cardinal processes: T helper (Th) cell type 2 (Th2)-polarized inflammation, bronchial hyperreactivity, and airway wall remodeling. However, the link between the immune-inflammatory phenotype and the structural-functional phenotype remains to be fully defined. The objective of these studies was to evaluate the relationship between the immunologic nature of chronic airway inflammation and the development of abnormal airway structure and function in a mouse model of chronic asthma. Using IL-4-competent and IL-4-deficient mice, we created divergent immune-inflammatory responses to chronic aeroallergen challenge. Immune-inflammatory, structural, and physiological parameters of chronic allergic airway disease were evaluated in both strains of mice. Although both strains developed airway inflammation, the profiles of the immune-inflammatory responses were markedly different: IL-4-competent mice elicited a Th2-polarized response and IL-4-deficient mice developed a Th1-polarized response. Importantly, this chronic Th1-polarized immune response was not associated with airway remodeling or bronchial hyperresponsiveness. Transient reconstitution of IL-4 in IL-4-deficient mice via an airway gene transfer approach led to partial Th2 repolarization and increased bronchial hyperresponsiveness, along with full reconstitution of airway remodeling. These data show that distinct structural-functional phenotypes associated with chronic airway inflammation are strictly dependent on the nature of the immune-inflammatory response.

The critical role of Bach2 in regulating type 2 chronic airway inflammation

2018 ◽  
Vol 30 (9) ◽  
pp. 397-402 ◽  
Author(s):  
Masakatsu Yamashita ◽  
Makoto Kuwahara
Keyword(s):  
Airway Inflammation ◽  
Critical Role ◽  
Chronic Airway
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