Evidence of the Local Immune Status in the Human Larynx

Author(s):  
Tadashi Nakashima ◽  
Hideichiro Tomita ◽  
Shun-ichi Chitose
Keyword(s):  
2009 ◽  
Vol 123 (S31) ◽  
pp. 1-4 ◽  
Author(s):  
T Nakashima ◽  
H Tomita ◽  
S Chitose ◽  
H Umeno ◽  
K Sato

AbstractThis study examined the local immune status and tumour marker expression in secretions and related tissue specimens from the laryngeal ventricle, comparing individuals with and without head and neck cancer. Laryngeal secretion and mucosal tissue specimens were collected during laryngeal microsurgery or surgical laryngectomy. The laryngeal secretions were found to contain immunological factors such as immunoglobulins G and A and secretory immunoglobulin A. A high level of the tumour marker Cyfra 21-1 was also detected in laryngeal secretions and mucosal tissue. Lows levels of secretory immunoglobulin A and Cyfra 21-1 were seen in the laryngeal mucosal tissue of controls and patients who had previously undergone radiation therapy. The level of secretory immunoglobulin A in laryngeal secretions closely correlated to the level of this immunoglobulin in mucosal tissue. These results indicate that local immunity is present in the human larynx; furthermore, it is strongly affected both by the presence of malignancy and by laryngeal cancer treatments such as irradiation.


2004 ◽  
Author(s):  
B. J. Gumilevsky ◽  
V. N. Tzygan ◽  
O. P. Gumilevskaya
Keyword(s):  

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
O D'Orlando ◽  
R Puff ◽  
A Henniger ◽  
S Krause ◽  
F Haupt ◽  
...  

2019 ◽  
Vol 322 (2) ◽  
pp. 27-31
Author(s):  
V.V. Fedyuk ◽  
◽  
E.I. Fedyuk ◽  
A.A. Tyutyunnikova ◽  
◽  
...  
Keyword(s):  

2020 ◽  
pp. 4-6

The present study was carried out in the Labs of collage of education for pure science, during period from January 2017 to endDecember of the same year. The immune status investigates for CLpatients by measuring the levels of cytokines (IL6and IL10) in sera using a technique enzyme-linked immune Sorbent adsorptive (ELISA). The study included 120 subjects with (60 CLpatientsL.majar and 60 CLpatients L. tropica with and (30) were healthy control. Increased mean Serum level of IL6 was in the observed in the total patients as compared to control Subjects (224.53pg/ml,70.70pg/ml), the result indicate there was significant difference at (p<0.05) ,such observation was consistent in the patient infected with L.majar and L. tropica (104 .90 pg/ml and 112.78 pg/ml) respectively. The results of the IL10 showed significant difference at (p<0.05)increased of mean Serum level in the total CL patients as compared to control Subjects(226.90 pg/ml 46.77pg/ml,).Ahighly significant difference at (p<0.05) increased observed in patients group infected with L.majar and followed by patients group infected L. tropica (112.78pg/ml and 114.12pg/ml) respectively.These results revealed that the excessive presence of cytokines might play a role in CL patients.


2017 ◽  
Vol 126 (3) ◽  
pp. 229-238 ◽  
Author(s):  
H Zha ◽  
G Lewis ◽  
A Alfaro ◽  
S Wang ◽  
Y Dong ◽  
...  

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1494-1499
Author(s):  
Shahid Ahmad Siddiqui

The episode of Covid19 (CORONA VIRUS) has become one of the greatest worldwide dangers around the world, which has now tainted over 1.7 million individuals with deaths of over 100,000 lives far & wide. Under these extraordinary conditions, there are no entrenched rules for cancer patients. The danger for genuine infection & passing in CORONA VIRUS cases increments with propelling age & existing co-morbid medical issue. After the rise of primary suspects in China during last month of 2019, enormous exploration endeavors have been in progress to comprehend the instruments of infectivity & contagiousness of coronavirus, a lethal infection liable for wretched endurance results. To limit the death rate, it gets judicious to distinguish indications quickly & utilize medicines suitably. Despite the fact that no fix has been set up, different clinical preliminaries are in progress to decide the most ideal system. Overseeing patients with cancer in these conditions is a fair task, considering their weak immune status & their ill health. Through this thorough audit, we talk about the effect of CORONA VIRUS on wellbeing & the immune system of who are infected, assessing the most recent care plan draws near & progressing clinical preliminaries. Also, we talk about difficulties confronted while treating cancer patients & propose possible ways to deal with these weak populace during pandemic.


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