Vascular Endothelial Growth Factor Attenuates Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line Induced by Cerebrospinal Fluid of Sporadic Amyotrophic Lateral Sclerosis Patients

2011 ◽  
Vol 8 (5) ◽  
pp. 322-330 ◽  
Author(s):  
Dinkar Kulshreshtha ◽  
K. Vijayalakshmi ◽  
Phalguni Anand Alladi ◽  
T.N. Sathyaprabha ◽  
Atchayaram Nalini ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amyotrophic Lateral Sclerosis ◽  
Cerebrospinal Fluid ◽  
Growth Factor ◽  
Motor Neuron ◽  
Cell Line ◽  
Sporadic Amyotrophic Lateral Sclerosis ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Lateral Sclerosis

scholarly journals Intracerebroventricular delivery of vascular endothelial growth factor in patients with amyotrophic lateral sclerosis, a phase I study

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Philip Van Damme ◽  
Petra Tilkin ◽  
Katarina Jansson Mercer ◽  
Joke Terryn ◽  
Ann D’Hondt ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amyotrophic Lateral Sclerosis ◽  
Growth Factor ◽  
Study Drug ◽  
Extension Study ◽  
Vascular Endothelial ◽  
Open Label ◽  
Open Label Extension ◽  
Endothelial Growth Factor ◽  
Lateral Sclerosis

Abstract We studied the feasibility, safety, tolerability and pharmacokinetics of intracerebroventricular delivery of recombinant human vascular endothelial growth factor in patients with amyotrophic lateral sclerosis. In this phase I study in patients with amyotrophic lateral sclerosis, the study drug was delivered using an implantable programmable pump connected to a catheter inserted in the frontal horn of the lateral cerebral ventricle. A first cohort received open label vascular endothelial growth factor (0.2, 0.8 and 2 µg/day), a second cohort received placebo, 0.8 or 2 µg/day of study dug. After the 3-month study period, all patients could participate in an open label extension study. In total, 18 patients with amyotrophic lateral sclerosis, seen at the University Hospitals in Leuven were included. The surgical procedure was well tolerated in most patients. One patient had transient postoperative seizures, due to an ischemic lesion along the catheter tract. The first 3-month study period was completed by 15/18 patients. Administration of 2 µg/day vascular endothelial growth factor resulted in sustained detectable levels in cerebrospinal fluid. A pulmonary embolus occurred in 3 patients, in 1 patient in the first 3-month study, and in 2 patients during the open label extension study. The study drug was well tolerated in the other patients, for up to 6 years in the open label extension study. Our study shows that intracerebroventricular administration of 2 µg/day of vascular endothelial growth factor to patients with amyotrophic lateral sclerosis is feasible, results in detectable cerebrospinal fluid levels and is well tolerated in most patients. The most common serious adverse event was a pulmonary embolus.

Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosis

Neurogenetics ◽  
2005 ◽  
Vol 6 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Alice Brockington ◽  
Janine Kirby ◽  
Dean Eggitt ◽  
Emma Schofield ◽  
Chris Morris ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Amyotrophic Lateral Sclerosis ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Coding Regions ◽  
Endothelial Growth Factor ◽  
Lateral Sclerosis
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