Irinotecan-Cetuximab-Bevacizumab as a Salvage Treatment in Heavily Pretreated Metastatic Colorectal Cancer Patients: A Retrospective Observational Study

Chemotherapy ◽  
2011 ◽  
Vol 57 (2) ◽  
pp. 138-144 ◽  
Author(s):  
J. Feliu Batlle ◽  
E. Cuadrado ◽  
J. Castro ◽  
T. Caldés ◽  
C. Belda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Observational Study ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Salvage Treatment ◽  
Retrospective Observational Study ◽  
Heavily Pretreated ◽  
Colorectal Cancer Patients

Percutaneous liver venous deprivation: outcomes in heavily pretreated metastatic colorectal cancer patients

HPB ◽  
2021 ◽  
Author(s):  
Mario Ghosn ◽  
Peter Kingham ◽  
Fourat Ridouani ◽  
Ernesto Santos ◽  
Hooman Yarmohammadi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Heavily Pretreated ◽  
Colorectal Cancer Patients

scholarly journals P-154 Combined oxaliplatin, irinotecan and fluorouracil as a rescue regimen for heavily pretreated metastatic colorectal cancer patients

2016 ◽  
Vol 27 ◽  
pp. ii45 ◽  
Author(s):  
G. Dos Santos Fernandes ◽  
M.I. Braghiroli ◽  
M. Artioli ◽  
C. Paterlini Ana ◽  
M.C. Teixeira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Heavily Pretreated ◽  
Colorectal Cancer Patients

Combination of Irinotecan, Oxaliplatin and 5-Fluorouracil as a Rechallenge Regimen for Heavily Pretreated Metastatic Colorectal Cancer Patients

2017 ◽  
Vol 49 (4) ◽  
pp. 470-475 ◽  
Author(s):  
Gustavo Dos Santos Fernandes ◽  
Maria Ignez Braghiroli ◽  
Michelle Artioli ◽  
Ana Carolina Carvalho Rocha Paterlini ◽  
Marcela Crosara Teixeira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Heavily Pretreated ◽  
Colorectal Cancer Patients

Impact on therapeutic index of a chronomodulated infusion at conventional doses of oxaliplatin (OHP), 5-fluorouracil (5-FU) and folinic acid (AF) in not previously treated metastatic colorectal cancer patients: A multicentric observational study

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14572-14572
Author(s):  
M. Pirovano ◽  
A. Zambelli ◽  
F. Gherardi ◽  
S. Masseroni ◽  
A. Nasisi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Observational Study ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Flow Rate ◽  
Dose Intensity ◽  
Therapeutic Index ◽  
Average Dose ◽  
Circadian Timing System ◽  
Colorectal Cancer Patients

14572 Background: FOLFOX4 schedule represents the standard treatment for metastatic colorectal cancer in EU, but is characterized by relevant adverse effects like G3–4 neutropenia in 42 % of patients (data from MOSAIC study). Adjustment of chemotherapy delivery schedule to the circadian timing system allows a significative improvement of tolerability. Objective of this multicentric observational study is the evaluation of therapeutic index of a OHP and 5-FU + AF based schedule at the same doses of FOLFOX 4, but administered according to a chronomodulated schedule (FLOX-1). Methods: From November 2005 to December 2006, we treated 41 metastatic colorectal cancer patients (19 male and 22 female, average age 65) with OHP 85 mg/m2/d1q14 sinusoidal 12 hour infusion with flow rate peak at 04.00 PM; 5-FU 1000 mg and AF 100 mg/m2/d1–2q14 sinusoidal 12 hour infusion with flow rate peak at 04.00 AM: a total of 258 cycles (5.5 average for patient) were administered using Melodie infusional programmable system (138 cycles) and CIP preprogrammed disposable system (128 cycles), all in homecare regimen. These data confirm a significative tolerability improvement of OHP, 5-FU and AF schedule when infused according to a chronomulated infusion prophile in metastatic colorectal cancer patients. Results: Overall average dose intensity was 39.1 mg/m2/w for OHP and 907.5 mg/m2/w for 5-FU respectively. No G3-G4 haematological, hepatic and neurological toxicity were observed. ORR (CR+PR) was 41%. No patient has been treated with G-CSF. Conclusions: These data confirm a significative tolerability improvement of OHP, 5-FU and AF schedule when infused according to a chronomulated infusion prophile in metastatic colorectal cancer patients. No significant financial relationships to disclose.

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