New Strategies for Medical Management of Castration-Resistant Prostate Cancer

Oncology ◽  
2011 ◽  
Vol 80 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Irène Asmane ◽  
Jocelyn Céraline ◽  
Brigitte Duclos ◽  
Lynn Rob ◽  
Valère Litique ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Medical Management ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
New Strategies

scholarly journals Strategies for Optimizing the Clinical Impact of Immunotherapeutic Agents Such as Sipuleucel-T in Prostate Cancer

2012 ◽  
Vol 10 (12) ◽  
pp. 1505-1512 ◽  
Author(s):  
Ravi A. Madan ◽  
Thomas Schwaab ◽  
James L. Gulley
Keyword(s):  
Prostate Cancer ◽  
Immune Responses ◽  
Standard Of Care ◽  
Clinical Impact ◽  
Castration Resistant Prostate Cancer ◽  
Therapeutic Vaccines ◽  
Therapeutic Cancer Vaccine ◽  
Castration Resistant ◽  
New Strategies

Sipuleucel-T is a therapeutic cancer vaccine that has shown improved survival in men with metastatic castration-resistant prostate cancer. As a first-in-class agent, it has been met with both fan-fare and controversy. A broad review of immune-based therapies may reveal the delayed clinical impact of sipuleucel-T to be a class effect. As new strategies of immune-based therapy are developed, their effects can be optimized through better understanding of how they affect disease differently from more standard therapeutics. Furthermore, combination therapy with agents that can either work synergistically with immune-activating therapies or deplete immune-regulating cells may result in more vigorous immune responses and improved clinical outcomes. In addition, therapeutic vaccines may be ideal candidates to safely combine with standard-of-care therapies because of their nonoverlapping toxicity profile. The ultimate role of immunotherapy may not be to supplant standard therapies, but rather to work in concert with them to maximize clinical benefit for patients.

New combination therapies for castration-resistant prostate cancer

2019 ◽  
Author(s):  
Mitchell G Lawrence ◽  
Laura H Porter ◽  
Daisuke Obinata ◽  
Shahneen Sandhu ◽  
Luke A Selth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
New Combination ◽  
Combination Therapies ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant
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