Motivational Intervention to Reduce Cannabis Use in Young People with Psychosis: A Randomized Controlled Trial

2011 ◽  
Vol 80 (5) ◽  
pp. 287-297 ◽  
Author(s):  
Charles Bonsack ◽  
Silvia Gibellini Manetti ◽  
Jérôme Favrod ◽  
Yves Montagrin ◽  
Jacques Besson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Young People ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Motivational Intervention ◽  
Randomized Controlled

scholarly journals A Web-Based Program for Cannabis Use and Psychotic Experiences in Young People (Keep It Real): Protocol for a Randomized Controlled Trial

10.2196/15803 ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. e15803
Author(s):  
Leanne Hides ◽  
Amanda Baker ◽  
Melissa Norberg ◽  
Jan Copeland ◽  
Catherine Quinn ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Cost Effectiveness ◽  
Young People ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Psychotic Experiences ◽  
Web Based ◽  
Randomized Controlled ◽  
The Past

Background Young Australians (16-25 years) have the highest rates of past-month cannabis use in the world. Cannabis use increases the risk of alcohol and other drug disorders and depressive disorders, and has a robust dose-response association with psychotic experiences (PEs) and disorders. PEs are subthreshold positive psychotic symptoms, including delusions and hallucinations, which increase the risk of substance use, depressive or anxiety disorders, and psychotic disorders. Access to effective web-based early interventions targeting both cannabis use and PEs could reduce such risk in young people. Objective The objective of this study is to determine the efficacy and cost-effectiveness of the Keep it Real web-based program compared to an information-only control website among young cannabis users (16-25 years) with PEs. Methods Participants are recruited online, and consenting individuals meeting inclusion criteria (aged 16-25 years, who have used cannabis in the past month and experienced PEs in the past 3 months) are automatically randomized to either the Keep it Real web-based program (n=249) or an information-only control website (n=249). Both websites are self-guided (fully automated). The baseline and follow-up assessments at 3, 6, 9, and 12 months are self-completed online. Primary outcome measures are weekly cannabis use, PEs, and the relative cost-effectiveness for quality-adjusted life years. Secondary outcomes include other substance use and related problems, PE-related distress, cannabis intoxication experiences, severity of cannabis dependence, depression/anxiety symptoms, suicidality, and mental well-being and functioning. Results Recruitment commenced in February 2019, and the results are expected to be submitted for publication in mid-2021. Conclusions This study protocol describes a large randomized controlled trial of a new web-based program for young cannabis users experiencing PEs. If effective, the accessibility and scalability of Keep it Real could help reduce growing public health concerns about the significant social, economic, and health impacts of cannabis use. Trial Registration Australian New Zealand Clinical Trials Registry ACTRN12618001107213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374800 International Registered Report Identifier (IRRID) DERR1-10.2196/15803

scholarly journals A Web-Based Program for Cannabis Use and Psychotic Experiences in Young People (Keep It Real): Protocol for a Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Leanne Hides ◽  
Amanda Baker ◽  
Melissa Norberg ◽  
Jan Copeland ◽  
Catherine Quinn ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Substance Use ◽  
Cost Effectiveness ◽  
Young People ◽  
Controlled Trial ◽  
Cannabis Use ◽  
Psychotic Experiences ◽  
Web Based ◽  
Randomized Controlled ◽  
The Past

BACKGROUND Young Australians (16-25 years) have the highest rates of past-month cannabis use in the world. Cannabis use increases the risk of alcohol and other drug disorders and depressive disorders, and has a robust dose-response association with psychotic experiences (PEs) and disorders. PEs are subthreshold positive psychotic symptoms, including delusions and hallucinations, which increase the risk of substance use, depressive or anxiety disorders, and psychotic disorders. Access to effective web-based early interventions targeting both cannabis use and PEs could reduce such risk in young people. OBJECTIVE The objective of this study is to determine the efficacy and cost-effectiveness of the <i>Keep it Real</i> web-based program compared to an information-only control website among young cannabis users (16-25 years) with PEs. METHODS Participants are recruited online, and consenting individuals meeting inclusion criteria (aged 16-25 years, who have used cannabis in the past month and experienced PEs in the past 3 months) are automatically randomized to either the <i>Keep it Real</i> web-based program (n=249) or an information-only control website (n=249). Both websites are self-guided (fully automated). The baseline and follow-up assessments at 3, 6, 9, and 12 months are self-completed online. Primary outcome measures are weekly cannabis use, PEs, and the relative cost-effectiveness for quality-adjusted life years. Secondary outcomes include other substance use and related problems, PE-related distress, cannabis intoxication experiences, severity of cannabis dependence, depression/anxiety symptoms, suicidality, and mental well-being and functioning. RESULTS Recruitment commenced in February 2019, and the results are expected to be submitted for publication in mid-2021. CONCLUSIONS This study protocol describes a large randomized controlled trial of a new web-based program for young cannabis users experiencing PEs. If effective, the accessibility and scalability of <i>Keep it Real</i> could help reduce growing public health concerns about the significant social, economic, and health impacts of cannabis use. CLINICALTRIAL Australian New Zealand Clinical Trials Registry ACTRN12618001107213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374800 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/15803

Randomized Controlled Trial of Interventions for Young People at Ultra High Risk for Psychosis

2010 ◽  
Vol 72 (04) ◽  
pp. 430-440 ◽  
Author(s):  
Alison R. Yung ◽  
Lisa J. Phillips ◽  
Barnaby Nelson ◽  
Shona M. Francey ◽  
Hok PanYuen ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
High Risk ◽  
Young People ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Ultra High Risk
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