Occurrence of Cleft-Palate and Alteration of Tgf-β3 Expression and the Mechanisms Leading to Palatal Fusion in Mice following Dietary Folic-Acid Deficiency

2011 ◽  
Vol 194 (5) ◽  
pp. 406-420 ◽  
Author(s):  
Estela Maldonado ◽  
Jorge Murillo ◽  
Carmen Barrio ◽  
Aurora del Río ◽  
Juliana Pérez-Miguelsanz ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cleft Palate ◽  
Folic Acid Deficiency ◽  
Palatal Fusion ◽  
Acid Deficiency

FOLIC-ACID DEFICIENCY IN PREGNANCY

The Lancet ◽  
1959 ◽  
Vol 274 (7110) ◽  
pp. 1033-1034 ◽  
Author(s):  
H.H. Francis ◽  
J.S. Scott
Keyword(s):  
Folic Acid ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
In Pregnancy

PARAPROTEINS IN FOLIC-ACID DEFICIENCY

The Lancet ◽  
1966 ◽  
Vol 287 (7430) ◽  
pp. 211-212 ◽  
Author(s):  
W. Roman ◽  
Margaret Coles
Keyword(s):  
Folic Acid ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

Neural Tube Defects: A Two-Pronged Approach to Primary Prevention

PEDIATRICS ◽  
1982 ◽  
Vol 70 (4) ◽  
pp. 648-650
Author(s):  
K. M. Laurence
Keyword(s):  
Folic Acid ◽  
Primary Prevention ◽  
Environmental Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Background ◽  
Genetic Factors ◽  
Maternal Nutrition ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

It is generally agreed that neural tube defects (NTD) have a multifactorial etiology when genetic factors render the developing fetus susceptible to intrauterine environmental factors acting during the fourth week of gestation to interfere with the orderly closure of the neural tube.1 As there is little likelihood that anything can be done about the genetic background, primary prevention would therefore be dependent on eliminating these factors from the environment or avoiding them. My intention here is to enlarge on some aspects of primary prevention of NTD as outlined by Smithells in an earlier issue (Pediatrics 69:498, 1982).2 One environmental factor, poor maternal nutrition and, more particularly, folic acid deficiency seems now to have been identified, but there are almost certainly a number of others.

Sign in / Sign up

Export Citation Format

Share Document