High White Matter Lesion Load Is Associated with Hippocampal Atrophy in Mild Cognitive Impairment

2011 ◽  
Vol 31 (2) ◽  
pp. 132-138 ◽  
Author(s):  
C. Eckerström ◽  
E. Olsson ◽  
N. Klasson ◽  
M. Bjerke ◽  
M. Göthlin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesion ◽  
Hippocampal Atrophy ◽  
Lesion Load

scholarly journals Heterogeneity in mild cognitive impairment: Differences in neuropsychological profile and associated white matter lesion pathology

2009 ◽  
Vol 15 (6) ◽  
pp. 906-914 ◽  
Author(s):  
LISA DELANO-WOOD ◽  
MARK W. BONDI ◽  
JOSHUA SACCO ◽  
NORM ABELES ◽  
AMY J. JAK ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Processing Speed ◽  
White Matter Lesion ◽  
Clinical Sample ◽  
Neuropsychological Profile ◽  
Executive Processing ◽  
Fluid Attenuated Inversion Recovery ◽  
Periventricular Lesion

AbstractThis study examined whether distinct neuropsychological profiles could be delineated in a sample with Mild Cognitive Impairment (MCI) and whether white matter lesion (WML) burden contributed to MCI group differences. A heterogeneous, clinical sample of 70 older adults diagnosed with MCI was assessed using cognitive scores, and WML was quantified using a semi-automated, volumetric approach on T2-weighted fluid-attenuated inversion recovery (FLAIR) images. Using cluster and discriminant analyses, three distinct groups (Memory/Language, Executive/Processing Speed, and Pure Memory) were empirically derived based on cognitive scores. Results also showed a dose dependent relationship of WML burden to MCI subgroup, with the Executive/Processing Speed subgroup demonstrating significantly higher levels of WML pathology when compared to the other subgroups. In addition, there was a dissociation of lesion type by the two most impaired subgroups (Memory/Language and Executive/Processing Speed) such that the Memory/Language subgroup showed higher periventricular lesion (PVL) and lower deep white matter lesion (DWML) volumes, whereas the Executive/Processing Speed demonstrated higher DWML and lower PVL volumes. Results demonstrate that distinct MCI subgroups can be empirically derived and reliably differentiated from a heterogeneous MCI sample, and that these profiles differ according to WML burden. Overall, findings suggest different underlying pathologies within MCI and contribute to our understanding of MCI subtypes. (JINS, 2009, 15, 906–914.)

P1-229: Rate of hippocampal atrophy is related to white matter atrophy and hypometabolism progression in mild cognitive impairment: A multimodal longitudinal study

2008 ◽  
Vol 4 ◽  
pp. T279-T279
Author(s):  
Gaël Chetelat ◽  
Florence Mezenge ◽  
Brigitte Landeau ◽  
Vincent de la Sayette ◽  
Fausto Viader ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Study ◽  
White Matter ◽  
Hippocampal Atrophy

scholarly journals Higher white matter hyperintensity lesion load is associated with reduced long-range functional connectivity

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Fanny Quandt ◽  
Felix Fischer ◽  
Julian Schröder ◽  
Marlene Heinze ◽  
Iris Lettow ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Functional Connectivity ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
White Matter Lesion ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Lesion Load ◽  
Vessel Disease

Abstract Cerebral small vessel disease is a common disease in the older population and is recognized as a major risk factor for cognitive decline and stroke. Small vessel disease is considered a global brain disease impacting the integrity of neuronal networks resulting in disturbances of structural and functional connectivity. A core feature of cerebral small vessel disease commonly present on neuroimaging is white matter hyperintensities. We studied high-resolution resting-state EEG, leveraging source reconstruction methods, in 35 participants with varying degree of white matter hyperintensities without clinically evident cognitive impairment in an observational study. In patients with increasing white matter lesion load, global theta power was increased independently of age. Whole-brain functional connectivity revealed a disrupted network confined to the alpha band in participants with higher white matter hyperintensities lesion load. The decrease of functional connectivity was evident in long-range connections, mostly originating or terminating in the frontal lobe. Cognitive testing revealed no global cognitive impairment; however, some participants revealed deficits of executive functions that were related to larger white matter hyperintensities lesion load. In summary, participants without clinical signs of mild cognitive impairment or dementia showed oscillatory changes that were significantly related to white matter lesion load. Hence, oscillatory neuronal network changes due to white matter lesions might act as biomarker prior to clinically relevant behavioural impairment.

Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment

2009 ◽  
Vol 462 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Feng Bai ◽  
Zhijun Zhang ◽  
David R. Watson ◽  
Hui Yu ◽  
Yongmei Shi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Hippocampal Atrophy
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