Cyclin-Dependent Kinase Inhibitor p16 and p21 Expression, and Cell Cycle Change in Human Lens Epithelial Cell Line SRA 01/04 following Contact Inhibition in Normal Culture

2011 ◽  
Vol 46 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Yoko Yamashiro ◽  
Hiroshi Sasaki ◽  
Nobuhiro Ibaraki ◽  
Kota Nagai ◽  
Yutaka Kawakami ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Kinase Inhibitor ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Epithelial Cell Line ◽  
Cyclin Dependent Kinase ◽  
Normal Culture ◽  
Human Lens Epithelial Cell ◽  
Cyclin Dependent Kinase Inhibitor

EAAT and Xc−Exchanger Inhibition Depletes Glutathione in the Transformed Human Lens Epithelial Cell Line SRA 01/04

2015 ◽  
pp. 1-10 ◽  
Author(s):  
Marlyn P. Langford ◽  
Thomas B. Redens ◽  
Chanping Liang ◽  
A. Scott Kavanaugh ◽  
Donald E. Texada
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Epithelial Cell Line ◽  
Human Lens Epithelial Cell

p21WAF1 Control of Epithelial Cell Cycle and Cell Fate

2002 ◽  
Vol 13 (6) ◽  
pp. 453-464 ◽  
Author(s):  
Wendy C. Weinberg ◽  
Mitchell F. Denning
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Fate ◽  
Cell Biology ◽  
Kinase Inhibitor ◽  
Growth Arrest ◽  
Nuclear Antigen ◽  
Central Position ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor

As a broad-acting cyclin-dependent kinase inhibitor, p21WAF1 occupies a central position in the cell cycle regulation of self-renewing tissues such as oral mucosa and skin. In addition to regulating normal cell cycle progression decisions, p21WAF1 integrates genotoxic insults into growth arrest and apoptotic signaling pathways that ultimately determine cell fate. As a result of its complex interactions with cell cycle machinery and response to mutagenic agents, p21WAF1 also has stage-specific roles in epithelial carcinogenesis. Finally, a view is emerging of p21WAF1 as not merely a cyclin-dependent kinase inhibitor, but also as a direct participant in regulating genes involved in growth arrest, senescence, and aging, thus providing an additional layer of control over matters of the cell cycle. This review discusses these various roles played by p21WAF1 in cell cycle control, and attempts to relate these to epithelial cell biology, with special emphasis on keratinocytes. (Abbreviations used include the following: Brdu, 5-Bromo-2-deoxyuridine; cdk, cyclin-dependent kinase; EGF, epidermal growth factor; KIP, kinase inhibitor protein; PCNA, proliferating cell nuclear antigen; and TPA, 12-O-tetradecanoylphorbol-13-acetate.)

Effect of growth factors on proliferation and expression of growth factor receptors in a human lens epithelial cell line

2006 ◽  
Vol 32 (3) ◽  
pp. 510-514 ◽  
Author(s):  
Juergen Kampmeier ◽  
Alicja Baldysiak-Figiel ◽  
Yvonne de Jong-Hesse ◽  
Gerhard K. Lang ◽  
Gabriele E. Lang
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Epithelial Cell ◽  
Cell Line ◽  
Growth Factor Receptors ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Epithelial Cell Line ◽  
Human Lens Epithelial Cell

bFGF Suppresses Serum-Deprivation-Induced Apoptosis in a Human Lens Epithelial Cell Line

1999 ◽  
Vol 249 (1) ◽  
pp. 123-130 ◽  
Author(s):  
YiQun Wang ◽  
HaiYing He ◽  
J.Samuel Zigler ◽  
Takeshi Iwata ◽  
Nobuhiro Ibaraki ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Lens Epithelial Cell ◽  
Serum Deprivation ◽  
Human Lens ◽  
Epithelial Cell Line ◽  
Human Lens Epithelial Cell ◽  
Induced Apoptosis

scholarly journals Comprehensive Profiling of Proteome and Ubiquitome Changes in Human Lens Epithelial Cell Line after Ultraviolet-B Irradiation

ACS Omega ◽  
2020 ◽  
Vol 5 (50) ◽  
pp. 32171-32182
Author(s):  
Xiaojuan Chen ◽  
Pengfei Li ◽  
Guowei Zhang ◽  
Lihua Kang ◽  
Bai Qin ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Lens Epithelial Cell ◽  
Ultraviolet B ◽  
Human Lens ◽  
Epithelial Cell Line ◽  
Human Lens Epithelial Cell ◽  
Ultraviolet B Irradiation
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