Clinical Characteristics, Biological Profile, and Outcome of Biphenotypic Acute Leukemia: A Case Series

2011 ◽  
Vol 125 (4) ◽  
pp. 210-218 ◽  
Author(s):  
Yanming Zhang ◽  
Depei Wu ◽  
Aining Sun ◽  
Huiying Qiu ◽  
Guangsheng He ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Characteristics ◽  
Case Series ◽  
Biological Profile ◽  
Biphenotypic Acute Leukemia

O52 Biological and clinical features of adult biphenotypic acute leukemia: a case series

Blood Reviews ◽  
2007 ◽  
Vol 21 ◽  
pp. S83
Author(s):  
M. Mikulic ◽  
D. Batinic ◽  
L. Rnjak ◽  
K. Dubravcic ◽  
M. Golemovic ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Features ◽  
Case Series ◽  
Biphenotypic Acute Leukemia

scholarly journals Biological features and outcome of biphenotypic acute leukemia: a case series

2008 ◽  
Vol 1 (4) ◽  
pp. 225-230 ◽  
Author(s):  
Mirta Mikulic ◽  
Drago Batinic ◽  
Mirna Sucic ◽  
Sanja Davidovic-Mrsic ◽  
Klara Dubravcic ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Case Series ◽  
Biological Features ◽  
Biphenotypic Acute Leukemia

scholarly journals Clinical Characteristics And Outcome Of Biphenotypic Acute Leukemia: 10 Case Reports And Literature Review

2019 ◽  
Vol Volume 11 ◽  
pp. 9297-9306
Author(s):  
Jifeng Yu ◽  
Yingmei Li ◽  
Haizhou Xing ◽  
Yue Pan ◽  
Hui Sun ◽  
...  
Keyword(s):  
Literature Review ◽  
Acute Leukemia ◽  
Clinical Characteristics ◽  
Case Reports ◽  
Biphenotypic Acute Leukemia

scholarly journals Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome

2019 ◽  
Vol 54 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Hyun Gyung Lee ◽  
Hee Jo Baek ◽  
Ho Sung Kim ◽  
Soo Min Park ◽  
Tai Ju Hwang ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Characteristics ◽  
Biphenotypic Acute Leukemia

Clinical, Biological Profile and Outcome of Biphenotypic Acute Leukemia: a Case Series.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1683-1683
Author(s):  
Yanming Zhang ◽  
Wu Depei ◽  
Aining Sun ◽  
Huiying Qiu ◽  
Guangsheng He ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Conflicts Of Interest ◽  
Statistical Significance ◽  
Case Series ◽  
Disease Free Survival ◽  
Normal Karyotype ◽  
Structural Rearrangement ◽  
Complex Karyotype ◽  
B Lymphoid ◽  
Biphenotypic Acute Leukemia

Abstract Abstract 1683 Biphenotypic acute leukemia (BAL) is a very rare type of acute leukemia, which presents a high heterogeneity and poor prognosis. We identified 51 cases (3.0%) BAL from 1693 newly diagnosed acute leukemia patients according to the EGIL scoring system between January 2003 and July 2009. The biological features, treatment and outcome of 39 evaluable BAL patients were analyzed retrospectively. There were 23 (59.0%) cases of myeloid and B-lymphoid (M/B) phenotype, 14 (35.9%) cases of myeloid and T-lymphoid (M/T) phenotype, one case (2.6%) of trilineage phenotype or B-lymphoid and T-lymphoid phenotype respectively. The high expressions of CD34 (84.6%) and HLA-DR (54.5%) on the blast cells of BAL support the notion that BAL probably arises from hemopoietic stem/progenitor cells. It seemed that CD7-positive patients had poorer median survivals comparing with those CD7-negative patients, however, there was no statistical difference (P=0.076). Abnormal karyotypes were detected in 75.7% of 37 BAL patients with valid analysis and displayed a high heterogeneity, which were associated with structural rearrangement and numerical abnormalities including t(8;21) (16.2%), t(9;22) (13.5%), structural rearrangement of 11 chromosome (16.2%), 11q23 (5.4%), complex karyotype (21.6%) and other abnormal karyotypes (10.8%). Combined regimens for both AML and ALL, ALL-type regimens appeared a better complete remission (CR) rate than AML-type regimens (71.4% vs. 63.6% vs. 33.3%). The median survival for overall survival (OS) and disease-free survival (DFS) in our series was 14 and 12 months, the probability of OS and DFS at 2 years was 26.0% and 18.5%, respectively. No statistical differences were observed in CR rate, OS and DFS between M/B and M/T cases. It showed that BAL patients with complex karyotype or rearrangement of 11 chromosome had a significantly worse survival in contrast to normal karyotype, t(8;21) and t(9;22) group (P=0.001). Although BAL with t(8;21) seemed to be appeared a better survival than normal karyotype and t(9;22) group, there were no statistical significance (P=0.436). Our data indicate that combined-type regimens or ALL-based protocols are more effective and complex karyotype, rearrangement of 11 chromosome have the unfavorable prognosis for BAL. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Clinical characteristics and outcome of children with biphenotypic acute leukemia

Haematologica ◽  
2009 ◽  
Vol 94 (12) ◽  
pp. 1682-1690 ◽  
Author(s):  
A. S. Al-Seraihy ◽  
T. M. Owaidah ◽  
M. Ayas ◽  
H. El-Solh ◽  
M. Al-Mahr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Characteristics ◽  
Biphenotypic Acute Leukemia

Biphenotypic Acute Leukemia Treated With Acute Myeloid Leukemia Regimens: A Case Series

2009 ◽  
Vol 101 (3) ◽  
pp. 270-272 ◽  
Author(s):  
Songul Serefhanoglu ◽  
Yahya Buyukasik ◽  
Hakan Goker ◽  
Nilgun Sayinalp ◽  
Osman I. Ozcebe
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Leukemia ◽  
Myeloid Leukemia ◽  
Case Series ◽  
Biphenotypic Acute Leukemia ◽  
Acute Myeloid

scholarly journals Etiologies and clinical characteristics of young patients with angle-closure glaucoma: a 15-year single-center retrospective study

2021 ◽  
Author(s):  
Feng Gao ◽  
Jiajian Wang ◽  
Junyi Chen ◽  
Xiaolei Wang ◽  
Yuhong Chen ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Anterior Segment ◽  
Young Patients ◽  
Case Series ◽  
Neovascular Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Uncommon Presentation ◽  
Underlying Causes

Abstract Purpose To investigate the etiologies and the clinical characteristics of angle-closure glaucoma (ACG) patients younger than 40 years old in Chinese. Methods Inpatients with diagnosis of ACG and diagnosed age younger than or equal to 40 years old, who were admitted in Eye, Ear, Nose, and Throat Hospital Fudan University from 2002 to 2017, were included in this retrospective non-comparative case series. The underlying causes and clinical features for all the patients were analyzed by comprehensive review of medical charts. Results A total of 298 patients (463 eyes) met the criteria, including 153 females (51.3%) and 145 males (48.7%); the mean age was 25.6 ± 13.0 years. Primary angle-closure glaucoma (PACG), uveitis, and anterior segment dysgenesis (ASD) were the top three etiologies in our patients, which accounted for 32.6%, 20.3%, and 15.1% of the total patients respectively. PACG mainly occurs after 30 years of age and ASD is the top reason of ACG in patients younger than 20 years old. Other known etiologies include iridocorneal endothelial syndrome, neovascular glaucoma, nanophthalmos, retinitis pigmentosa, spherophakia, bestrophinopathy, persistent fetal vasculature, iridociliary cysts, congenital retinoschisis, Marfan’s syndrome, retinopathy of prematurity, familial exudative vitreoretinopathy, congenital retinal folds, Coat’s disease, and neurofibromatosis. Conclusions We described the uncommon presentation of ACG in Chinese young patients. Although unusual, most of the etiologies could be identified. Therefore, more careful and comprehensive examinations are needed for early detection and timely treatment for young ACG patients.

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