Gene Therapy for Head and Neck Cancer

2011 ◽  
pp. 141-151 ◽  
Author(s):  
Waleed M. Abuzeid ◽  
Daqing Li ◽  
Bert W. O’Malley Jr.
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer

Alloantigen gene therapy for head and neck cancer: Evaluation of animal models

Head & Neck ◽  
2003 ◽  
Vol 25 (4) ◽  
pp. 274-279 ◽  
Author(s):  
Lyon L. Gleich ◽  
Ya-Qin Li ◽  
Shunan Li ◽  
Jack L. Gluckman ◽  
Peter J. Stambrook
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Animal Models ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Gene Therapy for Head and Neck Cancer Using Vaccinia Virus Expressing IL-2 in a Murine Model, with Evidence of Immune Suppression

2001 ◽  
Vol 4 (6) ◽  
pp. 551-558 ◽  
Author(s):  
Hongxing Qin ◽  
Joseph Valentino ◽  
Subha Manna ◽  
Pulak K. Tripathi ◽  
Malaya Bhattacharya-Chatterjee ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Vaccinia Virus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Immune Suppression ◽  
Murine Model

Viral gene therapy for head and neck cancer

2015 ◽  
Vol 129 (4) ◽  
pp. 314-320 ◽  
Author(s):  
J P Hughes ◽  
G Alusi ◽  
Y Wang
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Relevant Literature ◽  
P53 Gene ◽  
Oncolytic Viruses ◽  
Treatment Modalities ◽  
Viral Gene ◽  
Viral Gene Therapy

AbstractBackground:Viral gene therapy is a promising new treatment modality for head and neck cancer. This paper provides the reader with a review of the relevant literature in this field.Results:There are government licensed viral gene therapy products currently in use for head and neck cancer, utilised in conjunction with established treatment modalities. The viruses target tumour-associated genes, with the first licensed virus replacing p53 gene function, which is frequently lost in tumourigenesis. Oncolytic viruses selectively destroy cancer cells through viral replication and can be armed with therapeutic transgenes.Conclusion:Despite considerable advances in this field over the last 40 years, further research is needed to improve the overall efficacy of the viruses and allow their widespread utilisation in the management of head and neck cancer.

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