Habitual Physical Exercise Improves Macrophage IL-6 and TNF-α Deregulated Release in the Obese Zucker Rat Model of the Metabolic Syndrome

2011 ◽  
Vol 18 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Leticia Martín-Cordero ◽  
Juan José García ◽  
María Dolores Hinchado ◽  
Elena Bote ◽  
Rafael Manso ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Physical Exercise ◽  
Rat Model ◽  
Zucker Rat ◽  
The Metabolic Syndrome ◽  
Obese Zucker Rat ◽  
Tnf Α

scholarly journals Red raspberry (Rubus idaeus) consumption attenuates inflammation in the obese Zucker rat, a model of the Metabolic Syndrome (OR24-01-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Natalie VandenAkker ◽  
Stefano Vendrame ◽  
Dorothy Klimis-Zacas
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Food Consumption ◽  
Zucker Rat ◽  
Red Raspberry ◽  
High Blood Glucose ◽  
The Metabolic Syndrome ◽  
Obese Zucker Rat ◽  
Tnf Α ◽  
Inflammatory State

Abstract Objectives Metabolic syndrome (MetS) is a major public health problem that is escalating quickly globally. MetS is defined as a combination of obesity, high blood pressure, high blood glucose, low high-density lipoprotein and high cholesterol resulting in a pro-thrombotic and pro-inflammatory state. This study investigated the effect of whole red raspberry (WRR) consumption on inflammation in the obese Zucker rat (OZR), a model of the MetS. Methods At 8 weeks of age, male OZR (n = 16) and their lean littermates (LZR) (n = 16) were placed on a control (C) or an 8% w/w WRR-enriched diet for 8 weeks. Body weight and daily food consumption was measured. Circulating levels of inflammatory cytokines and their gene expression in the liver and adipose tissue (AT) were evaluated. Results No significant differences were observed in body weight or food consumption between diet groups. Consumption of WRR significantly reduced the plasma level of pro-inflammatory molecule, C-reactive protein (CRP) in the OZR compared to OZR-C (1024 ± 108.74 μg/ml vs 4250 ± 1120.12 μg/ml, p < 0.05) respectively. Plasma levels of interleukin-6 (IL-6), a pro-inflammatory cytokine decreased in the OZR consuming a WRR diet compared to the OZR-C (20.69 ± 1.41 pg/ml vs 50.50 ± 3.66 pg/ml, p < 0.0001) respectively. Following the consumption of WRR, the expression of pro-inflammatory molecules IL-6 and tumor necrosis factor-alpha (TNF-α) in the OZR significantly down-regulated (p < 0.01 and p < 0.05) respectively, in the AT. The expression of pro-inflammatory markers IL-6, TNF-α, and nuclear factor kappa-B (NF-ΚB) also significantly down-regulated (p < 0.01, p < 0.0001 and p < 0.05) respectively, following the consumption of WRR in the OZR compared to the OZR-C. Conclusions The results from the present study demonstrate that daily consumption of WRR improves the pro-inflammatory state associated with MetS. Funding Sources National Processed Raspberry Council USDA National Institute of Food and Agriculture Hatch FutureCeuticals (Momence, IL USA)

scholarly journals Improvement of Cardiac Fibrosis Biomarkers through Inflammation Inhibition by Green Tea and Decaffeinated Light Roasted Green Coffee Extract Combination Administration in Metabolic Syndrome Rat Model

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1013
Author(s):  
Mifetika Lukitasari ◽  
Mohammad Saifur Rohman ◽  
Dwi Adi Nugroho ◽  
Nila Aisyah Wahyuni ◽  
Mukhamad Nur Kholis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Green Tea ◽  
Rat Model ◽  
Cardiac Fibrosis ◽  
Significant Risk ◽  
Green Coffee ◽  
The Metabolic Syndrome ◽  
Tnf Α ◽  
Tgf Β1

Background: Metabolic syndrome is a significant risk factor for cardiovascular diseases. Green tea and green coffee extracts, antioxidant and anti-inflammatory agents may participate in metabolic syndrome-induced cardiac fibrosis alleviation. However, the effect of combination of those extracts still needs exploration. Therefore, this study investigated the effect of green tea and decaffeinated light roasted green coffee extracts and their combination in metabolic syndrome-induced cardiac fibrosis rats. Methods: Metabolic syndrome rat model was i1nduced through high-fat high sucrose diets feeding for 8 weeks and injection of low dose streptozotocin at the 2nd week. The metabolic syndrome rats were divided into 4 experimental groups metabolic syndrome rats (MS); metabolic syndrome rats treated with 300 mg/ kg b.w green tea extract (GT); metabolic syndrome rats treated with 200 mg/ kg b.w decaffeinated light roasted green coffee extract (GC); metabolic syndrome rats treated with the combination of the two extracts (CE); and a normal control (NC) group was added. Angiotensin 2 level was analyzed by ELISA method. Gene expression of NF-κB, TNF-α, IL-6, Tgf-β1, Rac-1, and α-sma were analyzed by touchdown polymerase chain reaction methods. Results: Metabolic syndrome rats treated with green tea and decaffeinated light roasted green coffee significantly decreased angiotensin-2 serum level and cardiac inflammation and fibrosis gene expression level (NF-κB, TNF-α, IL-6, Tgf-β1, Rac-1, and α-sma). More significant alleviation was observed in the combination group. Conclusion: This study suggested that combination of green tea and decaffeinated light roasted green coffee extracts showed better improvement in metabolic syndrome-induced cardiac fibrosis rat model compared to that of single extract administration through inflammation inhibition

Vascular function in the metabolic syndrome and the effects on skeletal muscle perfusion: lessons from the obese Zucker rat

2006 ◽  
Vol 42 ◽  
pp. 145-160 ◽  
Author(s):  
Jefferson C. Frisbee ◽  
Michael D. Delp
Keyword(s):  
Metabolic Syndrome ◽  
Vascular Function ◽  
Human Condition ◽  
Therapeutic Interventions ◽  
Western Society ◽  
Zucker Rat ◽  
Metabolic Demand ◽  
Muscle Perfusion ◽  
The Metabolic Syndrome ◽  
Obese Zucker Rat

The increased prevalence of obesity in Western society has been well established for many years, and with this trend, the prevalence of other associated pathologies including insulin resistance, dyslipidaemia, hypertension and the genesis of a proinflammatory and prothrombotic environment within individuals is also rapidly increasing, resulting in a condition known as the~metabolic syndrome. From a physiological perspective, one of the most severe consequences of the metabolic syndrome is a progressive inability of the cardiovascular system to adequately perfuse tissues and organs during either elevated metabolic demand and, if sufficiently severe, under basal levels of demand. For the study of the metabolic syndrome, the OZR (obese Zucker rat) represents an important tool in this effort, as the metabolic syndrome in these animals results from a chronic hyperphagia, and thus can be an excellent representation of the human condition. As in afflicted humans, OZR experience an attenuated functional and reactive hyperaemia, and can ultimately experience an ischaemic condition in their skeletal muscles at rest. The source of this progressive ischaemia appears to lie at multiple sites, as endothelium-dependent vasodilator responses are strongly impaired in OZR, and specific constrictor processes (e.g. adrenergic tone) may be enhanced. Whilst these active processes may contribute to a reduction in blood flow under resting conditions or with mild elevations in metabolic demand, an evolving structural alteration to individual microvessels (reduced distensibility) and microvascular networks (reduced microvessel density) also develop and may act to constrain perfusion at higher levels of metabolic demand. Given that constrained muscle perfusion in the metabolic syndrome appears to reflect a highly integrated, multi-faceted effect in OZR, and probably in humans as well, therapeutic interventions must be designed to address each of these contributing elements.

Red raspberry (Rubus idaeus) consumption restores the impaired vasoconstriction and vasorelaxation in the aorta of the obese zucker rat, a model of the metabolic syndrome

2020 ◽  
pp. 1-13
Author(s):  
Natalie E. VandenAkker ◽  
Stefano Vendrame ◽  
Panagiotis Tsakiroglou ◽  
Dorothy Klimis-Zacas
Keyword(s):  
Metabolic Syndrome ◽  
Vascular Function ◽  
Vascular Tone ◽  
Rubus Idaeus ◽  
Relaxation Response ◽  
Zucker Rat ◽  
Red Raspberry ◽  
The Metabolic Syndrome ◽  
Obese Zucker Rat ◽  
Pre Treatment

Metabolic Syndrome (MetS) increases the risk of cardiovascular disease. Whole red raspberry (WRR) consumption on vascular function was investigated in the obese Zucker rat (OZR), model of MetS. Male OZR and their lean littermates (LZR) were placed on a control (C) or an 8% w/w WRR-enriched diet for 8 weeks. Phenylephrine (Phe)-induced vasoconstriction and acetylcholine (Ach)-induced vasorelaxation were measured in aortic rings in the presence or absence of L-N-monomethyl-arginine (L-NMMA) and mefenamic acid (MFA). Phe-induced vasoconstriction was lower in the OZR-C compared to LZR-C (p <  0.05). The WRR diet partially restored aortic response in the OZR-WRR aorta (p <  0.05) compared to OZR- C. The OZR-WRR group pre-treated with L-NMMA increased compared to OZR-C (p <  0.05). Pre-treatment with L-NMMA, maximal relaxation response was higher in the OZR compared to the LZR (p <  0.05). With L-NMMA, maximal relaxation response in OZR-WRR (p <  0.05) was lower compared to the OZR-C. Prostacyclin I2 concentration was higher in the OZR compared to the LZR (p <  0.05) and was attenuated in the OZR-WRR (p <  0.05). Aortic expression of eNOS and COX-2 were downregulated in the OZR-WRR (p <  0.05). In conclusion, WRR restores the impaired vascular tone of the OZR by enhancing Phe-induced vasoconstriction and attenuating Ach-induced vasorelaxation.

Whole Red Raspberry (Rubus idaeus)-Enriched Diet Is Hepatoprotective in the Obese Zucker Rat, a Model of the Metabolic Syndrome

2020 ◽  
Author(s):  
Natalie E. VandenAkker ◽  
Stefano Vendrame ◽  
Panagiotis Tsakiroglou ◽  
Marissa McGilvrey ◽  
Dorothy Klimis-Zacas
Keyword(s):  
Metabolic Syndrome ◽  
Rubus Idaeus ◽  
Zucker Rat ◽  
Red Raspberry ◽  
The Metabolic Syndrome ◽  
Obese Zucker Rat

A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model

2017 ◽  
Vol 8 (3) ◽  
pp. 1293-1298 ◽  
Author(s):  
Andrea Bell ◽  
Soheila Korourian ◽  
Huawei Zeng ◽  
Joshua Phelps ◽  
Reza Hakkak
Keyword(s):  
Rat Model ◽  
Liver Steatosis ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Body Weights

Low daidzeinversushigh daidzein mean (±SD) body weights over 8 weeks.

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