scholarly journals Different Expressions and DNA Methylation Patterns of Lysophosphatidic Acid Receptor Genes in Mouse Tumor Cells

Pathobiology ◽  
2010 ◽  
Vol 77 (6) ◽  
pp. 309-314 ◽  
Author(s):  
Kyoko Okabe ◽  
Mai Hayashi ◽  
Naoko Wakabayashi ◽  
Yasuna Yamawaki ◽  
Miki Teranishi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Cells ◽  
Lysophosphatidic Acid ◽  
Mouse Tumor ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor ◽  
Methylation Patterns

Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells

2011 ◽  
Vol 405 (3) ◽  
pp. 450-454 ◽  
Author(s):  
Mai Hayashi ◽  
Kyoko Okabe ◽  
Yasuna Yamawaki ◽  
Miki Teranishi ◽  
Kanya Honoki ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cells ◽  
Lysophosphatidic Acid ◽  
Lung Tumor ◽  
Rat Lung ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor

Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells

2011 ◽  
Vol 50 (8) ◽  
pp. 635-642 ◽  
Author(s):  
Kyoko Okabe ◽  
Mai Hayashi ◽  
Yasuna Yamawaki ◽  
Miki Teranishi ◽  
Kanya Honoki ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Lysophosphatidic Acid ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor ◽  
Rat Tumor

scholarly journals A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator

2019 ◽  
Vol 295 (6) ◽  
pp. 1474-1488
Author(s):  
Xuan Zheng ◽  
Yinghui Jia ◽  
Lei Qiu ◽  
Xinyi Zeng ◽  
Liangliang Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Lysophosphatidic Acid ◽  
Therapeutic Interventions ◽  
Tumor Xenograft ◽  
Mouse Tumor ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor ◽  
Cancer Management

Lysophosphatidic acid receptor 6 (LPAR6) is a G protein–coupled receptor that plays critical roles in cellular morphology and hair growth. Although LPAR6 overexpression is also critical for cancer cell proliferation, its role in liver cancer tumorigenesis and the underlying mechanism are poorly understood. Here, using liver cancer and matched paracancerous tissues, as well as functional assays including cell proliferation, quantitative real-time PCR, RNA-Seq, and ChIP assays, we report that LPAR6 expression is controlled by a mechanism whereby hepatocyte growth factor (HGF) suppresses liver cancer growth. We show that high LPAR6 expression promotes cell proliferation in liver cancer. More importantly, we find that LPAR6 is transcriptionally down-regulated by HGF treatment and that its transcriptional suppression depends on nuclear receptor coactivator 3 (NCOA3). We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade. Moreover, depletion of either LPAR6 or NCOA3 significantly inhibited tumor cell growth in vitro and in vivo (in mouse tumor xenograft assays), similar to the effect of the HGF treatment. Collectively, our findings indicate an epigenetic link between LPAR6 and HGF signaling in liver cancer cells, and suggest that LPAR6 can serve as a biomarker and new strategy for therapeutic interventions for managing liver cancer.

Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells

2010 ◽  
Vol 457 (6) ◽  
pp. 669-676 ◽  
Author(s):  
Megumu Tsujino ◽  
Minako Fujii ◽  
Kyoko Okabe ◽  
Toshio Mori ◽  
Nobuyuki Fukushima ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Lysophosphatidic Acid ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Acid Receptor ◽  
Methylation Patterns ◽  
Human Colon Cancer Cells
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