scholarly journals De novo Thrombotic Microangiopathy Induced by Cytomegalovirus Infection Leading to Renal Allograft Loss

2010 ◽  
Vol 32 (5) ◽  
pp. 491-496 ◽  
Author(s):  
Kristel De Keyzer ◽  
Steven Van Laecke ◽  
Patrick Peeters ◽  
Raymond Vanholder
Keyword(s):  
Thrombotic Microangiopathy ◽  
Cytomegalovirus Infection ◽  
Renal Allograft ◽  
De Novo ◽  
Renal Allograft Loss ◽  
Allograft Loss

Reducing De Novo Donor-Specific Antibody Levels during Acute Rejection Diminishes Renal Allograft Loss

2009 ◽  
Vol 9 (5) ◽  
pp. 1063-1071 ◽  
Author(s):  
M. J. Everly ◽  
J. J. Everly ◽  
L. J. Arend ◽  
P. Brailey ◽  
B. Susskind ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Specific Antibody ◽  
Renal Allograft ◽  
De Novo ◽  
Renal Allograft Loss ◽  
Allograft Loss ◽  
Antibody Levels

A case of renal allograft loss associated with thrombotic microangiopathy during pregnancy

2008 ◽  
Vol 22 ◽  
pp. 62-67
Author(s):  
Akihiro Tsuchimoto ◽  
Hideki Yotsueda ◽  
Michiya Shinozaki ◽  
Tadashi Nagara ◽  
Yusuke Kuroki ◽  
...  
Keyword(s):  
Thrombotic Microangiopathy ◽  
Renal Allograft ◽  
Renal Allograft Loss ◽  
Allograft Loss

EFFECTIVE REDUCTION OF IMMUNODOMINANT DE NOVO DONOR SPECIFIC ANTI-HLA ANTIBODY LEVELS DECREASES RENAL ALLOGRAFT LOSS.

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 33
Author(s):  
M Everly ◽  
J Everly ◽  
P Brailey ◽  
B Susskind ◽  
L Arend ◽  
...  
Keyword(s):  
Renal Allograft ◽  
De Novo ◽  
Effective Reduction ◽  
Renal Allograft Loss ◽  
Allograft Loss ◽  
Antibody Levels ◽  
Hla Antibody

scholarly journals Preceding T-Cell-Mediated Rejection Is Associated with the Development of Chronic Active Antibody-Mediated Rejection by de Novo Donor-Specific Antibody

Nephron ◽  
2020 ◽  
pp. 1-5
Author(s):  
Takahiro Tsuji ◽  
Sari Iwasaki ◽  
Keishi Makita ◽  
Teppei Imamoto ◽  
Naomichi Ishidate ◽  
...  
Keyword(s):  
T Cell ◽  
Specific Antibody ◽  
De Novo ◽  
Control Group ◽  
Antibody Mediated Rejection ◽  
Peritubular Capillaries ◽  
The Mean ◽  
Microvascular Inflammation ◽  
Renal Allograft Loss ◽  
Allograft Loss

<b><i>Aim:</i></b> Chronic active antibody-mediated rejection (CAABMR) is an important cause of late-stage renal allograft loss. Early inflammatory events such as acute rejection and infection after transplantation are considered to be the risk factors of de novo donor-specific antibody (dnDSA) production. In this study, we investigated the relationship between pre­disposing T-cell-mediated rejection and dnDSA-positive CAABMR. <b><i>Methods:</i></b> We recruited 365 patients who underwent ABO-compatible renal transplantation at our hospital. Among them, 16 patients diagnosed as having dnDSA-positive CAABMR were designated as a CAABMR group, and 38 randomly selected patients were designated as a control group. All biopsies from 1 month after transplantation were included in the study. The presence or absence of borderline changes (BLCs), acute T-cell-mediated rejection (ATMR), microvascular inflammation (MVI), and C4d positive on peritubular capillaries (C4d-P) was examined. <b><i>Results:</i></b> In the CAABMR group, BLC/ATMR was found in 12 cases (75%), and the mean duration until appearance of BLC/ATMR was 282.7 ± 328.7 days. C4d-P was found in 11 cases (68.8%), and the mean duration until its appearance was 1,432 ± 1,307 days. MVI was found in all cases, and the mean duration until its appearance was 1,333 ± 1,126 days. The mean duration until diagnosis of CAABMR was 2,268 ± 1,191 days. In the control group, BLC/ATMR was found in 13 cases (34.2%), and the mean duration until the appearance of BLC/ATMR was 173.1 ± 170.4 days. C4d-P was found in 2 cases (5.3%), and the durations until its appearance were 748 and 1,881 days. No cases of MVI were found in the control group. The frequency of BLC/ATMR was significantly higher in the CAABMR group (<i>p</i> &#x3c; 0.01). <b><i>Conclusion:</i></b> Preceding BLC/ATMR is associated with the development of CAABMR with dnDSA.

First-Year Renal Function Predicts Long-Term Renal Allograft Loss

2011 ◽  
Vol 43 (1) ◽  
pp. 106-112 ◽  
Author(s):  
I. Fonseca ◽  
M. Almeida ◽  
L.S. Martins ◽  
J. Santos ◽  
L. Dias ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Allograft ◽  
First Year ◽  
Renal Allograft Loss ◽  
Allograft Loss
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