scholarly journals A Comparison of the Antifungal Activity of Herbal Toothpastes against Other Brands of Toothpastes on Clinical Isolates of Candida albicans and Candida dubliniensis

2011 ◽  
Vol 20 (2) ◽  
pp. 112-117 ◽  
Author(s):  
Arjuna N.B. Ellepola ◽  
Zia U. Khan ◽  
Rachel Chandy ◽  
Leeba Philip
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Candida Dubliniensis ◽  
Clinical Isolates

scholarly journals Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans

2009 ◽  
Vol 58 (8) ◽  
pp. 1074-1079 ◽  
Author(s):  
Na Guo ◽  
Jingbo Liu ◽  
Xiuping Wu ◽  
Xingming Bi ◽  
Rizeng Meng ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Concentration Index ◽  
Inhibitory Concentration ◽  
Clinical Isolates ◽  
Standard Strain ◽  
Antagonistic Action ◽  
Microdilution Method ◽  
Interaction Intensity

Thymol (THY) was found to have in vitro antifungal activity against 24 fluconazole (FLC)-resistant and 12 FLC-susceptible clinical isolates of Candida albicans, standard strain ATCC 10231 and one experimentally induced FLC-resistant C. albicans S-1. In addition, synergism was observed for clinical isolates of C. albicans with combinations of THY–FLC and THY–amphotericin B (AMB) evaluated by the chequerboard microdilution method. The interaction intensity was determined by spectrophotometry for the chequerboard assay, and the nature of the interactions was assessed using two non-parametric approaches [fractional inhibitory concentration index (FICI) and ΔE models]. The interaction between THY–FLC or THY–AMB in FLC-resistant and -susceptible strains of C. albicans showed a high percentage of synergism by the FICI method and the ΔE method. The ΔE model gave results consistent with FICI, and no antagonistic action was observed in the strains tested.

scholarly journals Synergistic mutual potentiation of antifungal activity of Zuccagnia punctata Cav. and Larrea nitida Cav. extracts in clinical isolates of Candida albicans and Candida glabrata

Phytomedicine ◽  
2015 ◽  
Vol 22 (6) ◽  
pp. 666-678 ◽  
Author(s):  
Estefanía Butassi ◽  
Laura A. Svetaz ◽  
Juan J. Ivancovich ◽  
Gabriela E. Feresin ◽  
Alejandro Tapia ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Candida Glabrata ◽  
Clinical Isolates

Antifungal activity of Rosmarinus officinalis Linn. essential oil against Candida albicans, Candida dubliniensis, Candida parapsilosis and Candida krusei

2014 ◽  
Vol 5 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Lurdete Maria Rocha Gauch ◽  
Simone Soares Pedrosa ◽  
Renata Antunes Esteves ◽  
Fabíola Silveira-Gomes ◽  
Ely Simone Cajueiro Gurgel ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Candida Parapsilosis ◽  
Rosmarinus Officinalis ◽  
Candida Krusei ◽  
Candida Dubliniensis

scholarly journals Paradoxical antifungal activity and structural observations in biofilms formed by echinocandin-resistant Candida albicans clinical isolates

2013 ◽  
Vol 52 (2) ◽  
pp. 131-139 ◽  
Author(s):  
C. J. Walraven ◽  
S. M. Bernardo ◽  
N. P. Wiederhold ◽  
S. A. Lee
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Clinical Isolates

Comparison of the susceptibilities of clinical isolates of Candida albicans and Candida dubliniensis to essential oils

Mycoses ◽  
2010 ◽  
Vol 53 (1) ◽  
pp. 12-15 ◽  
Author(s):  
Patrícia Pozzatti ◽  
ÉRico Silva Loreto ◽  
Paulo Guilherme Markus Lopes ◽  
Margareth Linde Athayde ◽  
Janio Morais Santurio ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Essential Oils ◽  
Candida Dubliniensis ◽  
Clinical Isolates

scholarly journals Antimitotic activity of Piper nigrum on clinical isolates of candida

2019 ◽  
Vol 10 (2) ◽  
pp. 1167-1171
Author(s):  
Gayathri Karthikeyan ◽  
Geetha RV ◽  
Lakshmi Thangavelu
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Ethanolic Extract ◽  
Fungal Species ◽  
Clinical Isolates ◽  
Diffusion Method ◽  
Piper Nigrum ◽  
Disc Diffusion ◽  
Antimitotic Activity ◽  
Diffusion Technique

The objective of this study is to analyse the antimycotic activity of pepper on the clinical isolates of Candida. The extracts were prepared in the following concentrations in sterile water. 5mg/ml and 10mg/ml and 20mg/ml. 100µl of an extract of different concentrations were loaded on sterile filter paper discs measuring 6mm in diameter, so that the concentration of the extract on each disc was 500µg, 1000 µg and 2000µg respectively. The discs were dried and kept aseptically. Screening of antifungal activity [dis diffusion technique] The ethanolic extract of Piper nigrum was screened for antifungal activity by the disc diffusion method. Effect of three different concentrations (2000, 1000, 500,µg /disc) of the ethanolic extract Of Piper nigrum was tested against Candida albicans using disc diffusion technique. All the concentrations of the test solution inhibited the fungal species with varying degree of sensitivity. The inhibitory zone was measured with respect to the different concentration of the extracts which include 2000 µg/disc and 500 µg/disc at both room temperature and cold temperature (4-8°c). The inhibition zones were evaluated at 24 and 48 hrs. The result of this study revealed that the pepper oil has pronounced inhibitory activities against Candida albicans. This result is comparable with studies which have shown that Piper nigrum has a broad antibacterial activity. Since Piper nigrum is easily available and well-tolerated, it can be incorporated into medication for topical antifungal therapy as well.

scholarly journals Antifungal Activity of Thai Cajuput Oil and Its Effect on Efflux-Pump Gene Expression in Fluconazole-Resistant Candida albicans Clinical Isolates

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Pitchayaphong Keereedach ◽  
Karnjana Hrimpeng ◽  
Khaemaporn Boonbumrung
Keyword(s):  
Gene Expression ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Efflux Pump ◽  
Clinical Problem ◽  
Antifungal Drugs ◽  
Clinical Isolates ◽  
Common Mechanism ◽  
Fluconazole Resistant ◽  
Resistant Strains

Candidiasis caused by the fluconazole-resistant opportunistic pathogen Candida albicans is an intractable clinical problem that threatens immunocompromised or normal individuals. The most common mechanism of fluconazole resistance in C. albicans is the failure of cells to accumulate the drug due to increased expression of the efflux proteins encoded by the CDR1, CDR2, and MDR1 genes. Because the number of current antifungal drugs is limited, it is necessary to develop new therapeutic strategies. This study aimed to evaluate the antifungal activity of Thai Cajuput oil, its synergism with fluconazole, and its effect on efflux-pump gene expression in fluconazole-resistant C. albicans clinical isolates. Thus, we first detected the efflux-pump genes in fourteen resistant strains by PCR. The frequencies of the CDR1, CDR2, and MDR1 genes were 68.75%, 62.5%, and 87.5%, respectively, and these efflux-pump genes were distributed in three distinct patterns. Subsequently, the antifungal activity of Thai Cajuput oil was assessed by broth macrodilution and its synergism with fluconazole was evaluated by the checkerboard assay. The changes in the expression levels of CDR1, CDR2, and MDR1 after treatment with Thai Cajuput oil were analyzed by qRT-PCR. The MICs and MFCs of Thai Cajuput oil ranged from 0.31 to 1.25 μl/ml and 0.63 to 1.25 μl/ml, respectively, and its activity was defined as fungicidal activity. The MICs of the combination of Thai Cajuput oil and fluconazole were much lower than the MICs of the individual drugs. Interestingly, sub-MICs of Thai Cajuput oil significantly reduced the MDR1 expression level in resistant strains P < 0.05 . Our study suggests that Thai Cajuput oil can be used to create new potential combination therapies to combat the antifungal resistance of C. albicans.

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