Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children

2011 ◽  
Vol 154 (3) ◽  
pp. 236-245 ◽  
Author(s):  
Shinpei Torii ◽  
Akiko Torii ◽  
Komei Itoh ◽  
Atsuo Urisu ◽  
Akihiko Terada ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Lactobacillus Acidophilus ◽  
Serum Markers

scholarly journals Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Tae Ho Chung ◽  
Tae Jin Kang ◽  
Won-Kyung Cho ◽  
Ga Young Im ◽  
Geum Seon Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Herbal Medicine ◽  
Oral Administration ◽  
Aluminum Hydroxide ◽  
Lactobacillus Acidophilus ◽  
Hplc Analysis ◽  
Clinical Signs ◽  
The Novel ◽  
Fermented Product ◽  
Therapeutic Properties

This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and itsLactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced byL. acidophilusfermentation via increases in its indicator molecule.

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

scholarly journals Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis

2018 ◽  
Vol 154 (1) ◽  
pp. 37 ◽  
Author(s):  
Vicente Navarro-López ◽  
Ana Ramírez-Boscá ◽  
Daniel Ramón-Vidal ◽  
Beatriz Ruzafa-Costas ◽  
Salvador Genovés-Martínez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Young Patients ◽  
Topical Steroids ◽  
Probiotic Strains

Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-γ down-regulation in NC/Nga mice

2009 ◽  
Vol 122 (3) ◽  
pp. 567-572 ◽  
Author(s):  
Dong-Young Kim ◽  
Jung-A Jung ◽  
Tae-Ho Kim ◽  
Sang-Wan Seo ◽  
Sung-Ki Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions ◽  
Down Regulation ◽  
Ifn Γ

scholarly journals Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis

2016 ◽  
Vol 99 (7) ◽  
pp. 5039-5046 ◽  
Author(s):  
Kozo Yamamoto ◽  
Kazuhito Yokoyama ◽  
Takehisa Matsukawa ◽  
Sayaka Kato ◽  
Shinji Kato ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Lactobacillus Acidophilus ◽  
Adult Patients
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