Cytologic Characteristics and β-Catenin Immunocytochemistry on Smear Slide of Cribriform-Morular Variant of Papillary Thyroid Carcinoma

2011 ◽  
Vol 55 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Ja Seung Koo ◽  
Woohee Jung ◽  
Soon Won Hong
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant ◽  
Smear Slide

Cribriform-morular variant of papillary thyroid carcinoma: report of three cases and review of the literature

Pathology ◽  
2009 ◽  
Vol 41 (5) ◽  
pp. 509-512 ◽  
Author(s):  
Yingchun Dong ◽  
Xiaojun Zhou ◽  
Honglin Yin ◽  
Jiandong Wang ◽  
Hangbo Zhou ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Review Of The Literature ◽  
Cribriform Morular Variant

scholarly journals Cribriform-Morular Variant of Papillary Thyroid Carcinoma

2009 ◽  
Vol 131 (1) ◽  
pp. 134-142 ◽  
Author(s):  
José Cameselle-Teijeiro ◽  
Lia P. Menasce ◽  
Beng K. Yap ◽  
Rovel J. Colaco ◽  
Patricia Castro ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

Cribriform-morular variant of papillary thyroid carcinoma: an indication to screen for occult FAP

2014 ◽  
Vol 13 (4) ◽  
pp. 547-551 ◽  
Author(s):  
Rachel A. Levy ◽  
Vanessa W. Hui ◽  
Rupa Sood ◽  
Stephanie Fish ◽  
Arnold J. Markowitz ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

scholarly journals Familial Adenomatous Polyposis—Rendering a Diagnosis Based on Recognition of an Unusual Primary Thyroid Neoplasm

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
David F. Schaeffer ◽  
Eric M. Yoshida ◽  
David A. Owen ◽  
Kenneth W. Berean
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Clinical Features ◽  
Germline Mutations ◽  
Initial Diagnosis ◽  
Thyroid Neoplasm ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

It has been well established in the literature that the cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) has been observed with higher frequency in familial adenomatous polyposis (FAP) patients. In the usual setting, patients with FAP are identified based on their germline mutations and the diagnosis of thyroid neoplasm is made after the FAP diagnosis. We herein report a case in which the recognition of a CMVPTC led to the initial diagnosis of FAP. The histological and clinical features of CMVPTC are reviewed with emphasis on its relationship to FAP.

scholarly journals Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer

2017 ◽  
Vol 24 (4) ◽  
pp. R109-R121 ◽  
Author(s):  
Alfred King-yin Lam ◽  
Nassim Saremi
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
English Literature ◽  
Distant Metastases ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Recurrence Rates ◽  
Distinctive Type ◽  
Cribriform Morular Variant ◽  
Immunohistochemical Studies

The aim of this systematic review is to study the features of cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) by analysing the 129 documented cases in the English literature. The disease occurred almost exclusively in women. The median age of presentation for CMV-PTC was 24 years. Slightly over half of the patients with CMV-PTC had familial adenomatous polyposis (FAP). CMV-PTC presented before the colonic manifestations in approximately half of the patients with FAP. Patients with FAP often have multifocal tumours in the thyroid. Microscopic examination of CMV-PTC revealed predominately cribriform and morular pattern of cancer cells with characteristic nuclear features of papillary thyroid carcinoma. Psammoma body is rare. On immunohistochemical studies, β-catenin is diffusely positive in CMV-PTC. The morular cells in CMV-PTC are strongly positive for CD10, bcl-2 and E-cadherin. Pre-operative diagnosis of CMV-PTC by fine-needle aspiration biopsy could be aided by cribriform architecture, epithelial morules and β-catenin immunostaining. Mutations ofAPCgene are found in the patients with CMV-PTC associated with FAP. In addition, mutations inCTNNB1,RET/PTCrearrangement andPI3K3CAmutations have been reported.BRAFmutation is negative in all CMV-PTC tested. Compared to conventional papillary thyroid carcinoma, CMV-PTC had a lower frequency of lymph node metastases at presentation (12%) and distant metastases (3%) as well as lower recurrence rates (8.5%) and patients’ mortality rates (2%). To conclude, patients with CMV-PTC have distinctive clinical, pathological and molecular profiles when compared to conventional papillary thyroid carcinoma.

scholarly journals Case Report: Cribriform-Morular Variant of Encapsulated Papillary Thyroid Carcinoma

2015 ◽  
Vol 144 (suppl 2) ◽  
pp. A252-A252
Author(s):  
Angela DiPoto Brahmbhatt ◽  
Shubnum Chaudhery ◽  
Nestor Dela Cruz
Keyword(s):  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant
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