Integrin-mediated transforming growth factor-β activation

Zusammenfassung. Fisteln stellen nach wie vor eine der wichtigsten Komplikationen bei Patienten mit Morbus Crohn dar. Bei mindestens einem Drittel aller Morbus Crohn Patienten treten im Laufe der Erkrankung Fisteln auf. Eine dauerhafte Heilung der Fistel wird jedoch, auch unter Ausschöpfung sämtlicher medikamentöser und chirurgischer Therapieoptionen, nur in rund einem Drittel dieser Patienten erreicht. Der genaue molekulare Mechanismus der Fistelentstehung ist bis heute nicht ganz klar. Aus histopathologischer Sichtweise stellen Fisteln eine röhrenartige Struktur dar, welche von flachen epithelartigen Zellen ausgekleidet ist. Als ursächlicher Entstehungsmechanismus wird dabei die sogenannte epitheliale-zu-mesenchymale Transition (EMT) angesehen und es kann eine starke Expression der Entzündungsmediatoren Tumor Nekrose Faktor, Interleukin-13 und Transforming Growth Factor β in den Fistelarealen nachgewiesen werden. Zusätzlich zu den bereits etablierten, medikamentösen Therapieoptionen, also Antibiotika, Immunmodulatoren und anti-TNF Antikörper, stellt insbesondere der Einsatz der mesenchymalen Stammzelltherapie einen erfolgversprechenden Therapieansatz für die Zukunft dar.

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Learning more about the role of Latent transforming growth factor-β binding protein–1 (LTBP–1) – a knockout approach in mice

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-931634 ◽

2006 ◽

Vol 44 (01) ◽

Author(s):

F Drews ◽

S Knöbel ◽

A Bosio ◽

K Muhlack ◽

M Moser ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Binding Protein ◽

Transforming Growth Factor Β

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Faculty Opinions recommendation of Transforming growth factor-β/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10760957.13041056 ◽

2011 ◽

Author(s):

Elizabeth Kelly ◽

Jim Stahl

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Signalling Pathway ◽

Vernal Keratoconjunctivitis

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Faculty Opinions recommendation of Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717952682.793458095 ◽

2012 ◽

Author(s):

Jonathan Jones ◽

Kristina Kligys

Keyword(s):

Lung Cancer ◽

Growth Factor ◽

Cell Motility ◽

Cancer Cell ◽

Target Gene ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Lung Cancer Cell ◽

Integrin Α5β1 ◽

Cancer Cell Motility

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Faculty Opinions recommendation of Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717967484.793467143 ◽

2012 ◽

Author(s):

Moisés Selman ◽

Carolina Garcia de Alba

Keyword(s):

Lactic Acid ◽

Growth Factor ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Myofibroblast Differentiation ◽

Ph Dependent

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Faculty Opinions recommendation of Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717961086.793463969 ◽

2012 ◽

Author(s):

Darryl Knight

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Pulmonary Fibrosis ◽

Essential Role ◽

Transforming Growth Factor ◽

Growth Factor Receptor ◽

Transforming Growth Factor Β ◽

Receptor Ligand ◽

Epidermal Growth

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Faculty Opinions recommendation of Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718373681.793494772 ◽

2014 ◽

Author(s):

Frank Zaucke

Keyword(s):

Growth Factor ◽

Osteogenesis Imperfecta ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Common Mechanism

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Faculty Opinions recommendation of SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718901024.793509211 ◽

2015 ◽

Author(s):

Yefu Li ◽

Lin Xu

Keyword(s):

Growth Factor ◽

Bone Morphogenetic Protein ◽

Cross Talk ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Morphogenetic Protein

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Faculty Opinions recommendation of A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726313808.793517656 ◽

2016 ◽

Author(s):

Vinicio de Jesus Perez

Keyword(s):

Pulmonary Hypertension ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β

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