Urinary Neutrophil Gelatinase-Associated Lipocalin and Progression of Diabetic Nephropathy in Type 1 Diabetic Patients in a Four-Year Follow-Up Study

2011 ◽  
Vol 118 (2) ◽  
pp. c130-c135 ◽  
Author(s):  
Stine Elkjaer Nielsen ◽  
Henrik Post Hansen ◽  
Berit Ruud Jensen ◽  
Hans-Henrik Parving ◽  
Peter Rossing
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Follow Up Study ◽  
Neutrophil Gelatinase ◽  
Type 1 Diabetic Patients

scholarly journals Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients

2017 ◽  
Vol 5 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Abo El Magd El Bohy ◽  
Mona Hamed ◽  
Solaf Ahmed
Keyword(s):  
Diabetic Nephropathy ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Resistivity Index ◽  
Type 1 Diabetic Patients ◽  
Over Time

AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN.PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years. Forty diabetic patients did renal Doppler at baseline & after three years.RESULTS: HbA1, waist/hip ratio, albumin/creatinine ratio, lipid profile, NGAL, KIM-1, L-FABP and resistivity index (RI) were significantly increased in follow-up. Twenty patients (41.7%) showed progression to albuminuria. RI showed a significant increase in follow-up study. ROC curve showed that RI and NGAL had the highest sensitivity (100%), followed by L-FABP (90%) and lastly KIM-1 (63.6%) in the prediction of DN.CONCLUSION: High RI, NGAL, KIM-1 & L-FABP can be considered as early markers of diabetic nephropathy in type 1 diabetics and are associated with its progression over time, independent of albuminuria.

scholarly journals Improved prognosis in type 1 diabetic patients with nephropathy: A prospective follow-up study

2005 ◽  
Vol 68 (3) ◽  
pp. 1250-1257 ◽  
Author(s):  
Anne Sofie Astrup ◽  
Lise Tarnow ◽  
Peter Rossing ◽  
Lotte Pietraszek ◽  
Peter Riis Hansen ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Follow Up Study ◽  
Type 1 Diabetic Patients

Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study

Diabetes Care ◽  
1999 ◽  
Vol 22 (3) ◽  
pp. 478-483 ◽  
Author(s):  
H. H. Parving ◽  
L. Tarnow ◽  
F. S. Nielsen ◽  
P. Rossing ◽  
T. Mandrup-Poulsen ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Follow Up Study ◽  
Cyclosporine Nephrotoxicity ◽  
Type 1 Diabetic Patients
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