scholarly journals High-Salt Diet and Hypertension: Focus on the Renin-Angiotensin System

2011 ◽  
Vol 34 (1) ◽  
pp. 1-11 ◽  
Author(s):  
I. Drenjančević-Perić ◽  
B. Jelaković ◽  
J.H. Lombard ◽  
M.P. Kunert ◽  
A. Kibel ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin

scholarly journals Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet

2017 ◽  
Vol 6 (1) ◽  
pp. 29 ◽  
Author(s):  
Gabriel Cao ◽  
Silvana Lorena Della Penna ◽  
Nicolás Martín Kouyoumdzian ◽  
Marcelo Roberto Choi ◽  
Susana Gorzalczany ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
Immunohistochemical Expression ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
System Components

Prenatal high-salt diet impaired vasodilatation with reprogrammed renin–angiotensin system in offspring rats

2018 ◽  
Vol 36 (12) ◽  
pp. 2369-2379 ◽  
Author(s):  
Yanping Liu ◽  
Linglu Qi ◽  
Jue Wu ◽  
Ting Xu ◽  
Chunli Yang ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin

scholarly journals Renal responses to three types of renin–angiotensin system blockers in patients with diabetes mellitus on a high-salt diet

2011 ◽  
Vol 29 (12) ◽  
pp. 2454-2461 ◽  
Author(s):  
Norman K. Hollenberg ◽  
Naomi D.L. Fisher ◽  
Juerg Nussberger ◽  
George V. Moukarbel ◽  
Ebrahim Barkoudah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Patients With Diabetes ◽  
Renal Responses ◽  
Renin Angiotensin System Blockers

scholarly journals The cardiac renin-angiotensin system is responsible for high-salt diet-induced left ventricular hypertrophy in mice

2010 ◽  
Vol 12 (11) ◽  
pp. 1171-1178 ◽  
Author(s):  
Philippe Le Corvoisier ◽  
Christophe Adamy ◽  
Lucien Sambin ◽  
Bertrand Crozatier ◽  
Alain Berdeaux ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Renin Angiotensin System ◽  
Left Ventricular ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin

Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system

2002 ◽  
Vol 92 (2) ◽  
pp. 627-633 ◽  
Author(s):  
Eugene C. Fletcher ◽  
Natalia Orolinova ◽  
Michael Bader
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Low Salt ◽  
Episodic Hypoxia

By using an inspired oxygen fraction that produces oxyhemoglobin desaturation equivalent to that seen in human sleep apnea, we have demonstrated that 35 days of recurrent episodic hypoxia (every 30 s for 7 h/day) results in an 8–13 mmHg persistent increase in diurnal systemic mean arterial blood pressure (MAP) in rats. Blockade of angiotensin II receptors (AT1a) eliminates this response. Separate groups of male Sprague-Dawley rats were fed high-salt (8%), ad libitum-salt, or low-salt (0.1%) diets for 7 wk: 2 wk of wash-in for baseline blood pressure measurement and 5 wk of experimental conditions. Rats in each salt group were subjected to episodic hypoxia whereas controls remained unhandled under normoxic conditions. MAP remained at basal levels in all nonepisodic hypoxia controls as well as high-salt-diet episodic hypoxia-exposed rats. Ad lib and low-salt episodic hypoxia rats showed an increase in MAP from 106 and 104 mmHg at baseline to 112 and 113 mmHg, respectively ( P < 0.05). Whole kidney renin mRNA was suppressed in high-salt controls and episodic hypoxia rats, whereas kidney AT1a mRNA showed opposite changes. Suppression of the renin-angiotensin system with a high-salt diet blocks the increase in MAP in episodic hypoxia-challenged rats, in part by suppressing local tissue renin levels. Upregulation of the tissue angiotensin II system appears to be necessary for the chronic blood pressure changes that occur from episodic hypoxia.

scholarly journals High-salt diets during pregnancy affected fetal and offspring renal renin–angiotensin system

2013 ◽  
Vol 218 (1) ◽  
pp. 61-73 ◽  
Author(s):  
Caiping Mao ◽  
Rong Liu ◽  
Le Bo ◽  
Ningjing Chen ◽  
Shigang Li ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
Receptor Expression ◽  
Renal Development ◽  
Fetal Origins ◽  
Altered Expression ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Renal Functions

Intrauterine environments are related to fetal renal development and postnatal health. Influence of salty diets during pregnancy on renal functions and renin–angiotensin system (RAS) was determined in the ovine fetuses and offspring. Pregnant ewes were fed high-salt diet (HSD) or normal-salt diet (NSD) for 2 months during middle-to-late gestation. Fetal renal functions, plasma hormones, and mRNA and protein expressions of the key elements of renal RAS were measured in the fetuses and offspring. Fetal renal excretion of sodium was increased while urine volume decreased in the HSD group. Fetal blood urea nitrogen was increased, while kidney weight:body weight ratio decreased in the HSD group. The altered ratio was also observed in the offspring aged 15 and 90 days. Maternal and fetal plasma antidiuretic hormone was elevated without changes in plasma renin activity and Ang I levels, while plasma Ang II was decreased. The key elements of local renal RAS, including angiotensinogen, angiotensin converting enzyme (ACE), ACE2, AT1, and AT2receptor expression in both mRNA and protein, except renin, were altered following maternal high salt intake. The results suggest that high intake of salt during pregnancy affected fetal renal development associated with an altered expression of the renal key elements of RAS, some alterations of fetal origins remained after birth as possible risks in developing renal or cardiovascular diseases.

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