Common Carotid Artery Intima-Media Thickness: The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) Study Results

2010 ◽  
Vol 31 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Pierre-Jean Touboul ◽  
Eric Vicaut ◽  
Julien Labreuche ◽  
Monica Acevedo ◽  
Victor Torres ◽  
...  
Keyword(s):  
Latin America ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Cardiovascular Risk Factor ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Study Results

scholarly journals Carotid Intima-Media Thickness in Patients with Subclinical Hypothyroidism: A Prospective Controlled Study

2021 ◽  
Vol 44 (4) ◽  
pp. E39-45
Author(s):  
Anally J. Soto-García ◽  
Guillermo Elizondo-Riojas ◽  
Rene Rodriguez-Gutiérrez ◽  
Leonardo G. Mancillas-Adame ◽  
J. Gerardo González-González
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Subclinical Hypothyroidism ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Controlled Study ◽  
Overt Hypothyroidism ◽  
Media Thickness

Purpose: The association between subclinical hypothyroidism (SCH) and cardiovascular risk, particularly with a TSH <10 µIU/ml, remains controversial. The objective of our study was to assess the association between SCH and cardiovascular risk through carotid intima-media thickness, and alternatively, to evaluate its change after treatment with levothyroxine. Methods: A total of 54 individuals were included in the study: 18 with SCH; 18 with overt hypothyroidism (OH); and 18 healthy controls (HC). The carotid intima-media thickness was measured in each group. In SCH, follow-up was performed at three and six months after the start of levothyroxine treatment. Results: The mean age of the total population at baseline was 35.8 years. The median TSH in SCH was 6.15 µIU/ml. The carotid intima-media thickness (mean and standard deviation) was greater in SCH in comparison to the HC group: right common carotid artery (RCCA), 0.486 ± 0.106 mm and 0.413 ± 0.075 mm in SCH and HC, respectively, p=0.01 and left common carotid artery (LCCA), 0.511 ± 0.144 mm and 0.427 mm ± 0.090 in SCH and HC, respectively, p=0.03). In patients with SCH, there was a decrease in the carotid intima-media thickness after treatment with levothyroxine (RCCA and LCCA, p <0.05 at three and six months). Conclusions: There was an association between increased carotid intima-media thickness in patients with SCH in comparison with HC, even with a TSH <10 µIU/ml. The increase was reversed with levothyroxine therapy. The association of this increased thickness with important cardiovascular outcomes remains uncertain and should be evaluated in future studies.

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