Single Nucleotide Polymorphisms in the Phospholipase A2 Receptor Gene Are Associated with Genetic Susceptibility to Idiopathic Membranous Nephropathy

2011 ◽  
Vol 117 (3) ◽  
pp. c253-c258 ◽  
Author(s):  
Sejoong Kim ◽  
Ho Jun Chin ◽  
Ki Young Na ◽  
Suhnggwon Kim ◽  
Jieun Oh ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Phospholipase A2 ◽  
Genetic Susceptibility ◽  
Membranous Nephropathy ◽  
Receptor Gene ◽  
Idiopathic Membranous Nephropathy ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Phospholipase A2 Receptor

scholarly journals TRPC6 Single Nucleotide Polymorphisms and Progression of Idiopathic Membranous Nephropathy

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102065 ◽  
Author(s):  
Julia M. Hofstra ◽  
Marieke J. H. Coenen ◽  
Mascha M. V. A. P. Schijvenaars ◽  
Jo H. M. Berden ◽  
Johan van der Vlag ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

A novel time-resolved fluoroimmunoassay based on magnetic microspheres method for detecting antibodies against Phospholipase A2 Receptor

2021 ◽  
Author(s):  
ting li ◽  
qingqing wu ◽  
Xue Yang ◽  
Yueming liu ◽  
bo lin ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Disease Activity ◽  
Membranous Nephropathy ◽  
Magnetic Microspheres ◽  
Idiopathic Membranous Nephropathy ◽  
Serum Antibodies ◽  
Time Resolved ◽  
Phospholipase A2 Receptor

Background: The level of serum antibodies against the M-type phospholipase A2 receptor (anti-PLA2R-IgG) is closely related to the disease activity of idiopathic membranous nephropathy (IMN). Therefore, the establishment of a...

scholarly journals Phospholipase A2 Receptor (PLA2R1) Sequence Variants in Idiopathic Membranous Nephropathy

2013 ◽  
Vol 24 (4) ◽  
pp. 677-683 ◽  
Author(s):  
Marieke J.H. Coenen ◽  
Julia M. Hofstra ◽  
Hanna Debiec ◽  
Horia C. Stanescu ◽  
Alan J. Medlar ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy ◽  
Sequence Variants ◽  
Phospholipase A2 Receptor

Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder

2020 ◽  
Vol 34 (11) ◽  
pp. 1326-1330
Author(s):  
Iñigo Pallardo-Fernández ◽  
José Ramón Muñoz-Rodríguez ◽  
Carmen González-Martín ◽  
Luis F Alguacil
Keyword(s):  
Drug Abuse ◽  
Single Nucleotide Polymorphisms ◽  
Receptor Gene ◽  
Gene Variants ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Histamine H3 Receptor ◽  
Cocaine Use ◽  
H3 Receptor ◽  
Histamine H3

Background: Preclinical work revealed significant interactions between ligands of the histamine H3 receptor and different drugs of abuse. In the case of psychostimulants, the results reported are somewhat controversial and human data are still scarce, despite the fact that an inverse agonist of the H3 receptor (pitolisant) has reached the market after approval for the treatment of narcolepsy. Aims: We have studied associations between histamine H3 receptor gene variants and cocaine use disorder to increase the knowledge of the possible involvement of histamine H3 receptor in drug abuse. Methods: Seven single nucleotide polymorphisms of the histamine H3 receptor gene were genotyped by using a multiplexing assay in 248 samples of subjects with cocaine use disorder and 500 randomized samples of subjects representative of the Spanish population. Results: The study of the epidemiological information associated to the samples revealed that subjects with cocaine use disorder broadly abused alcohol, tobacco and cannabinoids. Two single nucleotide polymorphisms (rs3787430 and rs74627870) were found significantly associated with the occurrence of addiction and one more (rs13042865) was specifically related to the severity of cocaine dependence within drug abusers. Conclusions: The associations found in this study further extend the hypothesis that histamine H3 receptor function could be relevant in drug abuse in general and cocaine addiction in particular.

scholarly journals Hyaluronan-Mediated Motility Receptor Gene Single Nucleotide Polymorphisms and Risk of Breast Cancer

2008 ◽  
Vol 17 (12) ◽  
pp. 3618-3620 ◽  
Author(s):  
B. Kalmyrzaev ◽  
P. D.P. Pharoah ◽  
D. F. Easton ◽  
B. A.J. Ponder ◽  
A. M. Dunning ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Receptor Gene ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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