Novel Ribbon-Type Nuclear Factor of Activated T Cells Decoy Oligodeoxynucleotides Preclude Airways Hyperreactivity and Th2 Cytokine Expression in Experimental Asthma

2011 ◽  
Vol 155 (2) ◽  
pp. 129-140 ◽  
Author(s):  
Yutaka Nakamura ◽  
Hiromi Nagashima ◽  
Masachika Akiyama ◽  
Atsuko Sato ◽  
Takayuki Miyamoto ◽  
...  
Keyword(s):  
T Cells ◽  
Cytokine Expression ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Th2 Cytokine ◽  
Airways Hyperreactivity

scholarly journals Integration of Calcium and Cyclic AMP Signaling Pathways by 14-3-3

2000 ◽  
Vol 20 (2) ◽  
pp. 702-712 ◽  
Author(s):  
Chi-Wing Chow ◽  
Roger J. Davis
Keyword(s):  
T Cells ◽  
Cyclic Amp ◽  
Signaling Pathways ◽  
Interleukin 2 ◽  
Camp Signaling ◽  
Phosphorylation Sites ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Transcription Activity ◽  
Kinase A

ABSTRACT Calcium-stimulated nuclear factor of activated T cells (NFAT) transcription activity at the interleukin-2 promoter is negatively regulated by cyclic AMP (cAMP). This effect of cAMP is mediated, in part, by protein kinase A phosphorylation of NFAT. The mechanism of regulation involves the creation of a phosphorylation-dependent binding site for 14-3-3. Decreased NFAT phosphorylation caused by the calcium-stimulated phosphatase calcineurin, or mutation of the PKA phosphorylation sites, disrupted 14-3-3 binding and increased NFAT transcription activity. In contrast, NFAT phosphorylation caused by cAMP increased 14-3-3 binding and reduced NFAT transcription activity. The regulated interaction between NFAT and 14-3-3 provides a mechanism for the integration of calcium and cAMP signaling pathways.

Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation

2021 ◽  
pp. 166238
Author(s):  
Meredith J. Giblin ◽  
Taylor E. Smith ◽  
Garrett Winkler ◽  
Hannah A. Pendergrass ◽  
Minjae J. Kim ◽  
...  
Keyword(s):  
T Cells ◽  
Vascular Inflammation ◽  
Nuclear Factor ◽  
Activated T Cells
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