Expression Pattern of the ASPP Family Members in Endometrial Endometrioid Adenocarcinoma

Onkologie ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. 500-503 ◽  
Author(s):  
Wen-Kang Liu ◽  
Xiang-Yang Jiang ◽  
Jian-Kang Ren ◽  
Zhen-Xi Zhang
Keyword(s):  
Expression Pattern ◽  
Family Members ◽  
Endometrioid Adenocarcinoma ◽  
Endometrial Endometrioid Adenocarcinoma

High expression of cyclin A is associated with poor prognosis in endometrial endometrioid adenocarcinoma

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5395-5399 ◽  
Author(s):  
Simi Santala ◽  
Anne Talvensaari-Mattila ◽  
Ylermi Soini ◽  
Maria Honkavuori-Toivola ◽  
Markku Santala
Keyword(s):  
Poor Prognosis ◽  
Cyclin A ◽  
High Expression ◽  
Endometrioid Adenocarcinoma ◽  
Endometrial Endometrioid Adenocarcinoma

Keratin Granulomas in the Peritoneum on Frozen Section: A Case Report with Multiple Suspects and the Search for the Culprit

2021 ◽  
pp. 106689692110160
Author(s):  
Levon Katsakhyan ◽  
Xiaoming Zhang ◽  
Maria C. Reyes ◽  
Lauren E. Schwartz ◽  
Ashley F. Haggerty ◽  
...  
Keyword(s):  
Case Report ◽  
Dermoid Cyst ◽  
Frozen Section ◽  
Endometrioid Adenocarcinoma ◽  
Diagnostic Significance ◽  
Rare Finding ◽  
Fertility Sparing ◽  
Endometrial Endometrioid Adenocarcinoma

Keratin granulomas in the peritoneum are a rare finding with multiple etiologies and can be especially challenging for both the pathologist and the surgeon when these lesions are grossly visible. We report a case of a unique frozen section diagnostic scenario of evaluation of keratin granulomas in the peritoneum of a 47-year-old woman in the setting of multiple potential culprits: endometrial endometrioid adenocarcinoma following fertility sparing treatment, and a concurrent dermoid cyst. We discuss the various etiologies of keratin granulomas in the peritoneum, mechanism of their formation, diagnostic significance, as well as implications of fertility sparing treatments. To the best of our knowledge, this is the only case of keratin granulomas in the peritoneum with multiple distinct potential pathologic culprits as well the only case following fertility sparing treatment.

scholarly journals Expression pattern of twoFrizzled-related genes,Frzb-1 andSfrp-1, during mouse embryogenesis suggests a role for modulating action ofWnt family members

1998 ◽  
Vol 212 (3) ◽  
pp. 364-372 ◽  
Author(s):  
Bang H. Hoang ◽  
J. Terrig Thomas ◽  
Fadi W. Abdul-Karim ◽  
Kristen M. Correia ◽  
Ronald A. Conlon ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Family Members ◽  
Mouse Embryogenesis

Role of DNA polymerases family members in cancer: The pan-cancer perspective.

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 475-475
Author(s):  
Zhiwen Luo ◽  
Xinyu Bi ◽  
Xingang Bi
Keyword(s):  
Expression Pattern ◽  
Drug Target ◽  
Dna Polymerases ◽  
Family Members ◽  
Prognostic Biomarkers ◽  
Cancer Type ◽  
Sequencing Data ◽  
Clinical Value ◽  
Bioinformatics Analyses ◽  
Pan Cancer

475 Background: DNA polymerases family (DNA pols) has a lengthy reported significant influence on the initiation, development, and progress of cancer. However, the pan-cancer value of whole family members was poorly done. Our study intends to demonstrate the expression pattern and clinical cancer value of DNA pols members as prognostic biomarkers and a therapeutic target of pan-cancer. Methods: Comprehensive bioinformatics analyses were done using data from TCGA and CCLE. MultiCox regression was done to select tumor prognosis-related members. Nomogram was constructed to predict the overall survival (OS) across cancer patients. Transcription factor, GO, IPA, and GSEA enrichments were done to explore regulatory mechanisms and functions. Results: A total of 22 DNA pols were identified to have a potential to diagnostic value, and 10 DNA pols have a pan-cancer prognostic value under various stages, and cancer type, among which overexpression of 6 DNA-pols (POLA2, POLD1, POLD2, POLE2, POLE4, and POLQ) was found to be significantly related to worse outcomes regarding OS, while 4 DNA-pols (POLH, POLL, POLN, and REV1) significantly related to better outcomes. A 5-DNA pols based risk score (POLQ, POLD2, POLL, POLH, and REV1) was generated by MultiCox regression with a nomogram validated an accurate predictive efficacy. MYB Proto-Oncogene Like 2 (MYBL2) was identified as transcription factors of prognostic DNA pols in pan-cancer, and IPA mimic experiment reveals inhibiting MYBL2 could be a drug target to recover and balance the dysregulated expression pattern of DNA pols in pan-cancer. GO, IPA, and GSEA enrichments revealed functions and pathways altered by DNA pols in cancer, and the results were supported by pan-cancer cell sequencing data. Conclusions: DNA pols have a pan-cancer clinical value and can work as potential prognostic biomarkers. Furthermore, MYBL2 could be a drug target for pan-cancer.

Case–control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma

2008 ◽  
Vol 17 (4) ◽  
pp. 358-363 ◽  
Author(s):  
Toshimitsu Koizumi ◽  
Naoki Nakaya ◽  
Chikako Okamura ◽  
Yuki Sato ◽  
Taichi Shimazu ◽  
...  
Keyword(s):  
Case Control Study ◽  
Coffee Consumption ◽  
Case Control ◽  
Endometrioid Adenocarcinoma ◽  
Endometrial Endometrioid Adenocarcinoma ◽  
Control Study

scholarly journals Two Distinct Tumorigenic Processes in Endometrial Endometrioid Adenocarcinoma

2020 ◽  
Vol 190 (1) ◽  
pp. 234-251 ◽  
Author(s):  
Yuko Sugiyama ◽  
Osamu Gotoh ◽  
Nobuyuki Fukui ◽  
Norio Tanaka ◽  
Katsuhiko Hasumi ◽  
...  
Keyword(s):  
Endometrioid Adenocarcinoma ◽  
Endometrial Endometrioid Adenocarcinoma
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