Role of Th1 and Th2 Cells in Bacterial Infections (Part 1 of 3)

1996 ◽  
pp. 66-76 ◽  
Author(s):  
Sabine Daugelat ◽  
Stefan H.E. Kaufmann
Keyword(s):  
Bacterial Infections ◽  
Th2 Cells ◽  
Th1 And Th2

The role of TH1 and TH2 cells in a rodent malaria infection

Science ◽  
1993 ◽  
Vol 260 (5116) ◽  
pp. 1931-1934 ◽  
Author(s):  
A. Taylor-Robinson ◽  
R. Phillips ◽  
A Severn ◽  
S Moncada ◽  
F. Liew
Keyword(s):  
Malaria Infection ◽  
Th2 Cells ◽  
Rodent Malaria ◽  
Th1 And Th2

Role of Th1 and Th2 Cells in Neurologic Disorders

2015 ◽  
pp. 171-186
Author(s):  
Anja Windhagen ◽  
Lindsay B. Nicholson ◽  
Howard L. Weiner ◽  
Vijay K. Kuchroo ◽  
David A. Hafler
Keyword(s):  
Th2 Cells ◽  
Neurologic Disorders ◽  
Th1 And Th2

Distribution of Th1- and Th2-induced Anti-factor VIII IgG Subclasses in Congenital and Acquired Hemophilia Patients

2002 ◽  
Vol 88 (10) ◽  
pp. 568-575 ◽  
Author(s):  
Sijin Lei ◽  
Howard Lei ◽  
Daid Green ◽  
Joan Gill ◽  
Bianca Conti-Fine ◽  
...  
Keyword(s):  
Factor Viii ◽  
Hemophilia A ◽  
Igg Subclasses ◽  
T Cell Subsets ◽  
Th2 Cells ◽  
Th1 Cells ◽  
Acquired Hemophilia ◽  
Th1 And Th2

SummaryDevelopment of antibodies (Ab) that inhibit the procoagulant function of factor VIII (fVIII) seriously complicates the treatment of hemophilia A patients. It also causes acquired hemophilia, a rare yet serious autoimmune disease. The design of effective fVIII-specific tolerizing procedures will require elucidation of the role of the different CD4+ T cell subsets that drive inhibitor synthesis. To examine the contribution of Th1 and Th2 cells in the anti-fVIII Ab response, we measured the concentration of Th1- and Th2-driven anti-fVIII IgG subclasses in 17 patients with severe hemophilia A and 18 patients with acquired hemophilia. We found that both congenital and acquired hemophilia patients had similar and comparable proportions of Th1- and Th2-induced anti-fVIII Ab, suggesting a more important role of Th1 cells in the immune response to fVIII than previously appreciated. The distribution of anti-fVIII IgG subclasses was stable for periods of up to six months. More intense anti-fVIII Ab responses and higher inhibitor titers correlated with a predominance of Th2-driven subclasses. In contrast, Th1-driven anti-fVIII Ab were predominant in patients who had low anti-fVIII Ab concentrations, even when this was the result of successful immune tolerance or immunosuppressive therapy, which had caused drastic reduction or disappearance of inhibitors.Thus, synthesis of Th2-driven inhibitors occurs when the anti-fVIII Ab response is intense, while Th1 cells may be involved in the long-term maintenance of anti-fVIII Ab synthesis.

Role of Th1 and Th2 Cells in Neurologie Disorders

1996 ◽  
pp. 171-186 ◽  
Author(s):  
Anja Windhagen ◽  
Lindsay B. Nicholson ◽  
Howard L. Weiner ◽  
Vijay K. Kuchroo ◽  
David A. Hafler
Keyword(s):  
Th2 Cells ◽  
Th1 And Th2
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