T-Cell Subsets in Experimental Allergic Encephalomyelitis: Interactions between the Immune and Neuroendocrine Systems in the Regulation of Their Activity

1992 ◽  
pp. 60-71 ◽  
Author(s):  
Don Mason
Keyword(s):  
T Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
T Cell Subsets ◽  
Allergic Encephalomyelitis ◽  
Experimental Allergic ◽  
Neuroendocrine Systems

scholarly journals The immune response against myelin basic protein in two strains of rat with different genetic capacity to develop experimental allergic encephalomyelitis.

1975 ◽  
Vol 141 (1) ◽  
pp. 72-81 ◽  
Author(s):  
D E McFarlin ◽  
S C Hsu ◽  
S B Slemenda ◽  
F C Chou ◽  
R F Kibler
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
Cell Response ◽  
Basic Protein ◽  
T Cell Response ◽  
Skin Tests ◽  
Allergic Encephalomyelitis ◽  
Experimental Allergic

After challenge with guiena pig basic protein (GPBP) Lewis (Le) rats, which are homozygous for the immune response experimental allergic encephalomyelitis (Ir-EAE) gene, developed positive delayed skin tests against GPBP and the 43 residue encephalitogenic fragment (EF); in addition, Le rat lymph node cells (LNC) were stimulated and produced migration inhibitory factor (MIF) when incubated in vitro with these antigens. In contrast Brown Norway (BN) rats, which lack the Ir-EAE gene, did not develop delayed skin tests to EF and their LNC were not stimulated and did not produce MIF when incubated in vitro with EF. These observations indicate that the Ir-EAE gene controls a T-cell response against the EF. Le rats produced measurable anti-BP antibody by radioimmunoassay after primary challenge. Although no antibody was detectable in BN rats by radioimmunoassay, radioimmunoelectrophoresis indicated that a small amount of antibody was formed after primary immunization. After boosting intraperitoneally, both strains of rat exhibited a rise in anti-BP antibody; which was greater in Le rats. In both strains of rat the anti-BP antibody reacted with a portion of the molecule other than the EF. Since EF primarily evokes a T cell response, it is suggested that the EF portion of the BP molecule may contain a helper determinant in antibody production.

T cell receptors in autoimmune disease as targets for immune intervention

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 656-661 ◽  
Author(s):  
Hans Acha-Orbea ◽  
L. Steinman ◽  
H. O. McDevitt
Keyword(s):  
T Cell ◽  
Autoimmune Disease ◽  
T Cell Receptor ◽  
Experimental Allergic Encephalomyelitis ◽  
Antibody Therapy ◽  
Cell Receptor ◽  
Allergic Encephalomyelitis ◽  
Immune Intervention ◽  
Receptor Antibodies ◽  
Experimental Allergic

The optimal form of treatment for an autoimmune disease should be highly specific, have few side effects, and allow treatment of clinically apparent disease. One target that could fulfill these requirements is the T cell receptor. To answer the question whether treatment of autoimmune disesase is possible with anti-T cell receptor antibodies, the heterogeneity of T cell receptor elements utilized in the T cell mediated autoimmune disease experimental allergic encephalomyelitis was analyzed. The limited heterogeneity of these elements allowed prevention and treatment of clinical autoimmune disease with anti-T cell receptor monoclonal antibodies. These results and their potential value for other autoimmune diseases are discussed.Key words: T cell receptor, autoimmune disease, monoclonal antibody therapy, experimental allergic encephalomyelitis.

HgCl2-induced perturbation of the T cell network in experimental allergic encephalomyelitis

1991 ◽  
Vol 137 (2) ◽  
pp. 367-378 ◽  
Author(s):  
Jérôme Rossert ◽  
Lucette Pelletier ◽  
Régine Pasquier ◽  
Henri Villarroya ◽  
Rafael Oriol ◽  
...  
Keyword(s):  
T Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
Allergic Encephalomyelitis ◽  
Cell Network ◽  
Experimental Allergic

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 ◽  
Vol 31 (2) ◽  
pp. 165-177 ◽  
Author(s):  
Maha Ibrahim Mustafa ◽  
Per Diener ◽  
Höjeberg Bo ◽  
Peter Van der Meide ◽  
Tomas Olsson
Keyword(s):  
T Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
Interferon Γ ◽  
T Cell Immunity ◽  
Allergic Encephalomyelitis ◽  
Lewis Rats ◽  
Cell Immunity ◽  
Experimental Allergic
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