Executive Dysfunction and Left Frontal White Matter Hyperintensities Are Correlated with Neuropsychiatric Symptoms in Stroke Patients with Confluent White Matter Hyperintensities

2010 ◽  
Vol 30 (3) ◽  
pp. 254-260 ◽  
Author(s):  
Vincent C.T. Mok ◽  
Adrian Wong ◽  
Kelvin Wong ◽  
Winnie C.W. Chu ◽  
Yunyun Xiong ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Neuropsychiatric Symptoms ◽  
Executive Dysfunction ◽  
Stroke Patients ◽  
Frontal White Matter

scholarly journals Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137323 ◽  
Author(s):  
Caroline M. J. Loos ◽  
Pim Klarenbeek ◽  
Robert J. van Oostenbrugge ◽  
Julie Staals
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Perivascular Spaces ◽  
Lacunar Stroke ◽  
Stroke Patients

scholarly journals Microstructural degeneration underlies executive dysfunction after stroke

2020 ◽  
Author(s):  
Michele Veldsman ◽  
Emilio Werden ◽  
Natalia Egorova ◽  
Mohamed Salah Khlif ◽  
Amy Brodtmann
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Structural Equation ◽  
Executive Dysfunction ◽  
White Matter Integrity ◽  
Stroke Severity ◽  
Lesion Volume ◽  
Stroke Patients ◽  
Cerebrovascular Risk ◽  
Microstructural Integrity

ABSTRACTObjectiveExecutive dysfunction affects 40% of stroke patients and is associated with poor quality of life. Stroke severity and lesion volume rarely predict whether a patient will have executive dysfunction. Stroke typically occurs on a background of cerebrovascular burden, which impacts cognition and brain network structural integrity. We investigated whether measures of white matter microstructural integrity and cerebrovascular risk factors better explain executive dysfunction than markers of stroke severity.MethodsWe used structural equation modelling to examine multivariate relationships between cerebrovascular risk, white matter microstructural integrity (fractional anisotropy and mean diffusivity), stroke characteristics and executive dysfunction in 126 stroke patients (mean age 68.4 years), three months post-stroke, and compared to 40 age- and sex-matched control participants. Executive function was measured using the Trail Making Tests, Clock Drawing task and Rey Complex Figure copy task. Microstructural integrity was estimated using a standard pipeline to process diffusion weighted images.ResultsExecutive function was below what would be expected for age and education level in stroke patients (t-test compared to controls t(79)=5.75, p<0.001). A multivariate structural equation model illustrated the complex relationship between executive function, white matter integrity, stroke characteristics and cerebrovascular risk. Pearson’s correlations confirmed a stronger relationship between executive dysfunction and white matter integrity, than executive dysfunction and stroke severity. Mediation analysis showed the relationship between executive function and white matter integrity is mediated by cerebrovascular burden.InterpretationWhite matter microstructural degeneration of the superior longitudinal fasciculus in the executive control network better explains executive dysfunction than markers of stroke severity.

scholarly journals Prestroke Statins, Progression of White Matter Hyperintensities, and Cognitive Decline in Stroke Patients with Confluent White Matter Hyperintensities

2014 ◽  
Vol 11 (3) ◽  
pp. 606-611 ◽  
Author(s):  
Yunyun Xiong ◽  
Adrian Wong ◽  
Margherita Cavalieri ◽  
Reinhold Schmidt ◽  
Winnie W. C. Chu ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
Stroke Patients

scholarly journals Plasma tPA-Activity and Progression of Cerebral White Matter Hyperintensities in Lacunar Stroke Patients

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150740 ◽  
Author(s):  
Ellen C. van Overbeek ◽  
Julie Staals ◽  
Iris L. H. Knottnerus ◽  
Hugo ten Cate ◽  
Robert J. van Oostenbrugge
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Cerebral White Matter ◽  
Lacunar Stroke ◽  
Stroke Patients

P4-086: Frontal white matter hyperintensities correlate with depressive symptoms and functionality in mild Alzheimer's patients

2011 ◽  
Vol 7 ◽  
pp. S731-S731
Author(s):  
Basar Bilgic ◽  
Ali Bayram ◽  
Hale Alpsan ◽  
Ayfer Tumac ◽  
Hasmet Hanagasi ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Frontal White Matter

scholarly journals Dysexecutive syndrome and cerebrovascular disease in non-amnestic mild cognitive impairment: a systematic review of the literature

2012 ◽  
Vol 6 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Felipe Kenji Sudo ◽  
Carlos Eduardo Oliveira Alves ◽  
Gilberto Sousa Alves ◽  
Letice Ericeira-Valente ◽  
Chan Tiel ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Executive Dysfunction ◽  
Subcortical White Matter ◽  
Review Of The Literature ◽  
Extrapyramidal Signs ◽  
Made In

ABSTRACT Objective: Non-amnestic dysexecutive Vascular Mild Cognitive Impairment (VaMCI) may represent preclinical Vascular Dementia (VaD). The aim of this study was to summarize the clinical, neuropsychological and neuroimaging aspects of VaMCI; and to assess its patterns of progression to dementia. Methods: Searches were made in the ISI Web of Knowledge, PubMed and Lilacs databases, using the terms "mild cognitive impairment" and "executive function". Altogether, 944 articles were retrieved. Results: VaMCI cases had poorer performances on fronto-executive tasks, a higher prevalence of stroke, presence of periventricular and profound white matter hyperintensities on MRI images, as well as more extrapyramidal signs and behavioral symptoms. Executive dysfunction might be associated with disconnection of fronto-parietal-subcortical circuits. Progression to dementia was associated with baseline deficits in executive function, in simple sustained attention and language, and large periventricular WMH. Discussion: VaMCI develops with impairment in non-memory domains and subcortical white matter changes on MRI images, which are consistent with clinical and neuroimaging findings in VaD.

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