scholarly journals Role of GSTM1 and GSTT1 Polymorphism: Susceptibility to Oral Submucous Fibrosis in the North Indian Population

Oncology ◽  
2010 ◽  
Vol 79 (3-4) ◽  
pp. 181-186 ◽  
Author(s):  
Deepa Agrawal ◽  
Shalini Gupta ◽  
Deepti Agarwal ◽  
Om Prakash Gupta ◽  
Mohit Agarwal
Keyword(s):  
Indian Population ◽  
Oral Submucous Fibrosis ◽  
North Indian Population ◽  
The North ◽  
Submucous Fibrosis ◽  
Gstt1 Polymorphism

scholarly journals Polymorphism in the TP63 gene imparts a potential risk for leukemia in the North Indian population

2021 ◽  
Vol 21 (3) ◽  
pp. 1243-1249
Author(s):  
Amrita Bhat ◽  
Gh. Rasool Bhat ◽  
Sonali Verma ◽  
Ruchi Shah ◽  
Ashna Nagpal ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Indian Population ◽  
Taqman Assay ◽  
Genome Wide Association Studies ◽  
North Indian Population ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Jammu And Kashmir ◽  
The North

Background: The role of single nucleotide polymorphism rs10937405 (C>T) of the TP63 gene in cancer including leu- kemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown. Objectives: In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population. Methods: A total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay. Results: A statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51-2.48), p=1.2x10-6]. Conclusion: The current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations. Keywords: Single Nucleotide Polymorphism (SNPs); Leukemia; North Indian population; Tumour suppressor (TP63); Linkage Disequilibrium (LD); Genome wide association studies (GWAS); Jammu and Kashmir (J &K).

Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population

2012 ◽  
Vol 39 (10) ◽  
pp. 9383-9389 ◽  
Author(s):  
Tanima Ghosh ◽  
Shalini Gupta ◽  
Prachi Bajpai ◽  
Deepti Agarwal ◽  
Mohit Agarwal ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Indian Population ◽  
Oral Submucous Fibrosis ◽  
North Indian Population ◽  
Gstt1 Gene ◽  
Submucous Fibrosis

scholarly journals Association of NQO1 C609T (Pro187Ser) with Risk of Oral Submucous Fibrosis in Eastern Indian Population

2021 ◽  
Vol 6 (3) ◽  
pp. 187-193
Author(s):  
Sanjit Mukherjee ◽  
Sweta Mohanty ◽  
Atul Katarkar ◽  
Richa Dhariwal ◽  
Basudev Mahato ◽  
...  
Keyword(s):  
Indian Population ◽  
Oral Submucous Fibrosis ◽  
Transformation Rate ◽  
Areca Nut ◽  
Quinone Oxidoreductase ◽  
Increased Risk ◽  
Pcr Rflp ◽  
Submucous Fibrosis ◽  
Nqo1 C609t Polymorphism

Objective: Oral submucous fibrosis (OSF) is a debilitating disease mainly attributed to chewing areca nut with a 7.4-13% malignant transformation rate. The present study explores the role of NADPH quinone oxidoreductase 1 (NQO1) C609T (Pro187Ser) polymorphism in susceptibility to OSF among habitual areca nut chewers in an eastern Indian population. Material and Methods: In this hospital-based study, 152 controls and 179 OSF cases were genotyped at NQO1 C609T polymorphic site by PCR-RFLP and its effect on NQO1 expression in OSF tissue was studied to determine the risk of the disease. Results: Overall, about 18% of the total OSF cases were detected carrying minor TT alleles (Ser/Ser) p=0.026. When categorized by age, both CT (Pro/Ser) and TT (Ser/Ser) alleles were significantly higher (p= 0.003 & 0.004 respectively) in cases above 40years of age. NQO1 protein was 42% reduced in buccal tissues of heterozygous (Pro/Ser) carriers, whereas a 70% reduction was observed in TT (Ser/Ser) OSF cases. Conclusion: Our study suggests that the NQO1 C609T polymorphism confers increased risk for OSF in habitual chewers. 

scholarly journals Association of Genetic Variants of ELMO1 Gene With Diabetic Nephropathy in the North Indian Population

2020 ◽  
Author(s):  
Gurvinder Singh ◽  
Rubina Sharma ◽  
Priyanka Raina ◽  
Vishali Kalotra ◽  
Harkirat Sandhu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Physical Inactivity ◽  
Indian Population ◽  
Linkage Disequilibrium Mapping ◽  
North Indian Population ◽  
The North ◽  
High Doses ◽  
Stage Renal Disease ◽  
End Stage

Abstract Diabetic nephropathy (DN) is a major cause of renal failure globally including chronic kidney disease and end-stage renal disease (ESRD). Using comprehensive linkage disequilibrium mapping, we genotyped five polymorphisms from engulfment and cell motility 1 (ELMO1) gene (rs741301, rs7799004, rs1882080, rs11769038 and rs1345365) to evaluate its association with DN. BMI was observed to be low in DN cases as compared to the control groups, which is the result of haemodialysis and high doses of medication. Physical inactivity, lipid profile, urea and creatinine were observed to be the confounding factors correlated with DN. This study comprehensively evaluated ELMO1 in DN patients, T2D without Nephropathy and healthy controls from North Indian population and revealed significant association with DN. Haplotypes G-G-C-C and G-A-T-T provided ~2-fold risk towards DN development. In conclusion, the present study suggests the significant role of ELMO1 gene polymorphisms in the pathophysiology of DN in North-Indian population.

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