Effects of Antenatal Steroid Therapy on Neurodevelopment in an IUGR Mouse Model

2010 ◽  
Vol 28 (2) ◽  
pp. 79-86 ◽  
Author(s):  
Clarissa Velayo ◽  
Takuya Ito ◽  
Hiroshi Chisaka ◽  
Nobuo Yaegashi ◽  
Kunihiro Okamura ◽  
...  
Keyword(s):  
Mouse Model ◽  
Steroid Therapy ◽  
Antenatal Steroid

scholarly journals Molecular Patterns of Neurodevelopmental Preconditioning: A Study of the Effects of Antenatal Steroid Therapy in a Protein-Restriction Mouse Model

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Clarissa Velayo ◽  
Takuya Ito ◽  
Yupeng Dong ◽  
Miyuki Endo ◽  
Rika Sugibayashi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Microarray Analysis ◽  
Steroid Therapy ◽  
Regulatory Networks ◽  
Harmful Effect ◽  
High Stress ◽  
Protein Restriction ◽  
Late Gestation ◽  
Treatment Protocols ◽  
Antenatal Steroid

Introduction. Prenatal programming secondary to maternal protein restriction renders an inherent susceptibility to neural compromise in neonates and any addition of glucocorticosteroids results in further damage. This is an investigation of consequent global gene activity due to effects of antenatal steroid therapy on a protein restriction mouse model. Methods. C57BL/6N pregnant mice were administered control or protein restricted diets and subjected to either 100 μg/Kg of dexamethasone sodium phosphate with normosaline or normosaline alone during late gestation (E10–E17). Nontreatment groups were also included. Brain samples were collected on embryonic day 17 and analyzed by mRNA microarray analysis. Results. Microarray analyses presented 332 significantly regulated genes. Overall, neurodevelopmental genes were overrepresented and a subset of 8 genes allowed treatment segregation through the hierarchical clustering method. The addition of stress or steroids greatly affected gene regulation through glucocorticoid receptor and stress signaling pathways. Furthermore, differences between dexamethasone-administered treatments implied a harmful effect during conditions of high stress. Microarray analysis was validated using qPCR. Conclusion. The effects of antenatal steroid therapy vary in fetuses according to maternal-fetal factors and environmental stimuli. Defining the key regulatory networks that signal either beneficial or damaging corticosteroid action would result in valuable adjustments to current treatment protocols.

scholarly journals Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Jason D. Pole ◽  
Cameron A. Mustard ◽  
Teresa To ◽  
Joseph Beyene ◽  
Alexander C. Allen
Keyword(s):  
Risk Factor ◽  
Confidence Interval ◽  
Steroid Therapy ◽  
Independent Risk Factor ◽  
Cox Proportional Hazards ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Care Utilization ◽  
Lung Maturation ◽  
Antenatal Steroid

This study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood. A population-based cohort study of all pregnant women who resided in Nova Scotia, Canada, and gave birth to a singleton fetus between 1989 and 1998 was undertaken. After a priori specified exclusions, 80,448 infants were available for analysis. Using linked health care utilization records, incident asthma cases developed after 36 months of age were identified. Extended Cox proportional hazards models were used to estimate hazard ratios while controlling for confounders. Exposure to corticosteroids during pregnancy was associated with a risk of asthma in childhood between 3–5 years of age: adjusted hazard ratio of 1.19 (95% confidence interval: 1.03, 1.39), with no association noted after 5 years of age: adjusted hazard ratio for 5–7 years was 1.06 (95% confidence interval: 0.86, 1.30) and for 8 or greater years was 0.74 (95% confidence interval: 0.54, 1.03). Antenatal steroid therapy appears to be an independent risk factor for the development of asthma between 3 and 5 years of age.

The Effect of Antenatal Steroid Therapy on Early Inflammation Markers and Leukocyte Counts in Premature Infants

2020 ◽  
pp. 1-6
Author(s):  
Esra Beser Ozmen ◽  
Gulsum Kadioglu Simsek ◽  
Burak Ceran ◽  
Fuat Emre Canpolat ◽  
H. Gozde Kanmaz Kutman
Keyword(s):  
Premature Infants ◽  
Steroid Therapy ◽  
Inflammation Markers ◽  
Antenatal Steroid ◽  
Leukocyte Counts

25: Chorioamnionitis and antenatal steroid therapy: single vs repeat course?

2014 ◽  
Vol 210 (1) ◽  
pp. S16
Author(s):  
Kathleen Brookfield ◽  
Lisa Chao ◽  
Victoria Berger ◽  
Mariam Naqvi ◽  
Yasser El-Sayed ◽  
...  
Keyword(s):  
Steroid Therapy ◽  
Antenatal Steroid

Functional residual capacity and passive compliance measurements after antenatal steroid therapy in preterm infants

2001 ◽  
Vol 31 (6) ◽  
pp. 425-430 ◽  
Author(s):  
Cindy McEvoy ◽  
Susan Bowling ◽  
Kathleen Williamson ◽  
Marion Stewart ◽  
Manuel Durand
Keyword(s):  
Preterm Infants ◽  
Steroid Therapy ◽  
Functional Residual Capacity ◽  
Antenatal Steroid ◽  
Passive Compliance ◽  
Residual Capacity

Antenatal steroid therapy and childhood asthma: Is there a possible link?

2008 ◽  
Vol 70 (5) ◽  
pp. 981-989 ◽  
Author(s):  
Jason D. Pole ◽  
Cameron A. Mustard ◽  
Teresa To ◽  
Joseph Beyene ◽  
Alexander C. Allen
Keyword(s):  
Steroid Therapy ◽  
Childhood Asthma ◽  
Antenatal Steroid

scholarly journals Costs of hospitalization in preterm infants: impact of antenatal steroid therapy

2016 ◽  
Vol 92 (1) ◽  
pp. 24-31
Author(s):  
Joice Fabiola Meneguel Ogata ◽  
Marcelo Cunio Machado Fonseca ◽  
Milton Harumi Miyoshi ◽  
Maria Fernanda Branco de Almeida ◽  
Ruth Guinsburg
Keyword(s):  
Preterm Infants ◽  
Steroid Therapy ◽  
Antenatal Steroid

The Story of Antenatal Steroid Therapy before Preterm Birth

Neonatology ◽  
2015 ◽  
Vol 107 (4) ◽  
pp. 352-357 ◽  
Author(s):  
Mikko Hallman
Keyword(s):  
Preterm Birth ◽  
Steroid Therapy ◽  
Antenatal Steroid
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