Paediatric Cancer Treatment in Africa

P9 A study to investigate the impact of the COVID-19 pandemic on paediatric cancer patients: an international, multicentre, observational cohort study (COVIDPaedsCancer)

BJS Open ◽

10.1093/bjsopen/zrab032.008 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

Author(s):

◽

Soham Bandyopadhyay

Keyword(s):

Cohort Study ◽

Cancer Treatment ◽

Childhood Cancer ◽

Multivariate Logistic Regression Analysis ◽

Global Health Research ◽

Cancer Outcomes ◽

Paediatric Cancer ◽

Cancer Management ◽

Anti Cancer ◽

The Impact

Abstract Introduction Childhood cancers are a leading cause of non-communicable disease deaths for paediatric patients around the world. The COVID-19 pandemic may have impacted on global children’s cancer services, which can have consequences for childhood cancer outcomes. The Global Health Research Group on Children’s Non-Communicable Diseases (Global Children’s NCDs) is currently undertaking the first international study to determine the variation in paediatric cancer management during the COVID-19 pandemic, and the short to medium term impacts on childhood cancer outcomes. Methods and analysis This is a multicentre, international, cohort study that will use routinely collected hospital data in a de-identified and anonymised form. Patients will be recruited consecutively into the study, with a 12 -month follow-up period. Patients will be included if they are below the age of 18 years and undergoing anti-cancer treatment for the following cancers: Acute lymphoblastic leukaemia, Burkitt’s Lymphoma, Hodgkin's lymphoma, Wilms Tumour, Sarcoma, Retinoblastoma, Gliomas, Medulloblastomas and Neuroblastomas. Patients must be newly presented or be undergoing active anti-cancer treatment from the 12th March 2020 to the 12th December 2020. The primary objective of the study is to determine 30- and 90-day all-cause mortality rates. This study will examine the factors that influenced these outcomes. Chi-squared analysis will be used to compare mortality between low and middle-income countries and high-income countries. Multilevel, multivariate logistic regression analysis will be undertaken to identify patient-level and hospital-level factors affecting outcomes with adjustment for confounding factors. Ethics and dissemination At the host centre, this study was deemed to be exempt from ethical committee approval due to the use of anonymised registry data. At other centres, participating collaborators have gained local approvals in accordance with their institutional ethical regulations. Collaborators will be encouraged to present the results locally, nationally, and internationally. The results will be submitted for publication in a peer reviewed journal.

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An observational study of cancer treatment-induced dental abnormalities in paediatric cancer patients

Journal of Health Specialties ◽

10.4103/1658-600x.166493 ◽

2015 ◽

Vol 3 (4) ◽

pp. 228

Author(s):

Kaberi Das ◽

Munlima Hazarika ◽

Manigreeva Krishnatreya ◽

AmalChandra Kataki

Keyword(s):

Observational Study ◽

Cancer Treatment ◽

Cancer Patients ◽

Paediatric Cancer ◽

Dental Abnormalities

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Parental involvement in paediatric cancer treatment decisions

European Journal of Cancer Care ◽

10.1111/j.1365-2354.2009.01116.x ◽

2009 ◽

Vol 19 (5) ◽

pp. 621-630 ◽

Cited By ~ 31

Author(s):

K. MCKENNA ◽

J. COLLIER ◽

M. HEWITT ◽

H. BLAKE

Keyword(s):

Parental Involvement ◽

Cancer Treatment ◽

Treatment Decisions ◽

Paediatric Cancer

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Parental traumatic stress during and after paediatric cancer treatment

Acta Oncologica ◽

10.1080/02841860510029789 ◽

2005 ◽

Vol 44 (4) ◽

pp. 382-388 ◽

Cited By ~ 50

Author(s):

Annika Lindahl Norberg ◽

Frank Lindblad ◽

Krister K. Boman

Keyword(s):

Cancer Treatment ◽

Traumatic Stress ◽

Paediatric Cancer

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The guardians' perspective on paediatric cancer treatment in Malawi and factors affecting adherence

Pediatric Blood & Cancer ◽

10.1002/pbc.21703 ◽

2008 ◽

Vol 51 (5) ◽

pp. 639-642 ◽

Cited By ~ 51

Author(s):

Trijn Israëls ◽

Chawanangwa Chirambo ◽

Huib Caron ◽

Jan de Kraker ◽

Elizabeth Molyneux ◽

...

Keyword(s):

Cancer Treatment ◽

Paediatric Cancer ◽

Factors Affecting

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Scurvy: an unusual complication of paediatric cancer treatment

Skeletal Radiology ◽

10.1007/s00256-018-3103-5 ◽

2018 ◽

Vol 48 (6) ◽

pp. 995-998 ◽

Cited By ~ 4

Author(s):

Iain Irvine ◽

Triona Walshe ◽

Michael Capra ◽

Roisin Hayes

Keyword(s):

Cancer Treatment ◽

Unusual Complication ◽

Paediatric Cancer

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A narrative review of the late effects of paediatric cancer treatment within an educational setting: Existing evidence and where do we go from here?

Chronic Illness ◽

10.1177/17423953211043113 ◽

2021 ◽

pp. 174239532110431

Author(s):

Jessica Iyamu ◽

Jessica C Hodgson ◽

Rachael Sharpe

Keyword(s):

Cancer Treatment ◽

Late Effects ◽

Narrative Review ◽

Educational Setting ◽

Long Term Effects ◽

Paediatric Cancer ◽

Scientific Databases ◽

The United Kingdom ◽

Review Systematic

Objectives The late effects of paediatric cancer treatment within an educational context are an area that is relatively under researched within the United Kingdom. Methods To support this narrative review, systematic searches were conducted in key scientific databases between May and December 2020. Results Upon reviewing literature within this field, there are key considerations that should be addressed to provide clear and concise findings. These key considerations include clarification on whether the research undertaken focuses on the late or long term effects of paediatric cancer treatment, taking a consistent approach to data analysis with the aim to improve the validity of the study findings, utilising a mixed methodology to gain further depth to the findings as well as increasing the number of studies that focus on a specific tumour type rather than numerous types to allow a detailed study to be undertaken into the potential late effects a treatment for a specific tumour may elicit. Discussion If these key considerations are taken into account when conducting further research within this field, it would enable consistent findings to be utilised in providing the optimum educational provision for survivors of paediatric cancer who remain within the education system.

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Access to paediatric cancer care treatment in Mexico: responding to health system challenges and opportunities

Health Policy and Planning ◽

10.1093/heapol/czz164 ◽

2019 ◽

Vol 35 (3) ◽

pp. 291-301

Author(s):

Svetlana V Doubova ◽

Felicia Marie Knaul ◽

Víctor Hugo Borja-Aburto ◽

Sebastian Garcia-Saíso ◽

Marta Zapata-Tarres ◽

...

Keyword(s):

Health System ◽

Cancer Treatment ◽

Cancer Care ◽

Premature Mortality ◽

Paediatric Oncology ◽

Health Coverage ◽

Paediatric Cancer ◽

Quality Cancer Care ◽

Challenges And Opportunities ◽

Nation Wide Survey

Abstract In Mexico, paediatric cancer is the leading cause of death for children aged 0–18 years. This study analyses the main challenges for paediatric cancer care from the perspective of three key health systems functions: stewardship, financing and service delivery. The study used a mixed methods approach comprised of: (1) a scoping literature review, (2) an analysis of 2008–18 expenditures on paediatric cancer by the Fund for Protection against Catastrophic Expenditures (FPGC) of Seguro Popular and (3) a nation-wide survey of the supply capacity of 59 Ministry of Health (MoH) and 39 Mexican Institute of Social Security (IMSS) hospitals engaged in paediatric cancer care. The study found that while Mexico has made substantial progress towards universal health coverage (UHC) for paediatric cancer treatment, serious gaps persist. FPGC funds for paediatric cancer increased from 2008 to 2011 to reach US$36 million and then declined to US$13.6 million in 2018, along with the number of covered cases. The distribution of health professionals and paediatric oncology infrastructure is uneven between MoH and IMSS hospitals and across Mexican regions. Both institutions share common barriers for continuous and co-ordinated health care and lack monitoring activities that cripple their capacity to apply uniform standards for high-quality cancer care. In conclusion, achieving universal and effective coverage of paediatric cancer treatment is a critical component of UHC for Mexico. This requires periodic and ongoing assessment of health system performance specific to paediatric cancer to identify gaps and propose strategies for continued investment and improvement of access to care and health outcomes for this important cause of premature mortality.

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Returning to daily life: a qualitative interview study on parents of childhood cancer survivors in Germany

BMJ Open ◽

10.1136/bmjopen-2019-033730 ◽

2020 ◽

Vol 10 (3) ◽

pp. e033730 ◽

Cited By ~ 2

Author(s):

Mona L Peikert ◽

Laura Inhestern ◽

Konstantin A Krauth ◽

Gabriele Escherich ◽

Stefan Rutkowski ◽

...

Keyword(s):

Cancer Survivors ◽

Cancer Treatment ◽

Social Life ◽

Positive Impact ◽

Daily Life ◽

Qualitative Content Analysis ◽

Paediatric Cancer ◽

Family Responsibilities ◽

Partner Relationship ◽

Qualitative Interview Study

ObjectivesTo investigate experiences of parents of paediatric cancer survivors in cancer-related changes in the parents’ daily life (work life, family life, partner relationship and social life) during and after intensive cancer treatment and to examine the reintegration process with its impeding and facilitating factors.DesignThe design of this cross-sectional study involves a qualitative content analysis of semistructured interviews.SettingParticipants were consecutively recruited in clinical settings throughout Germany.ParticipantsForty-nine parents (59% female) of 31 cancer survivors (aged 0–17 at diagnosis of leukaemia or central nervous system tumour) were interviewed approximately 16–24 months after the end of intensive cancer treatment (eg, chemotherapy).ResultsDuring treatment, more than 70% of parents reported difficulties reconciling paid work, household and family responsibilities and caring for the ill child. Couples spent little time with each other and approximately 25% reported dispute and burden. Many parents did not have enough energy for pursuing any hobbies during treatment. However, over the long term, being faced with the child’s disease also led to strengthened relationships, new priorities, improved communication, increased mutual trust and greater appreciation for daily life. Supportive social networks (family/friends/employers), a strong partner relationship prior to the diagnosis and the use of psychosocial services (eg, family-oriented rehabilitation) had a positive impact. At the time of the interview, most families had adapted well. However, reintegration took time and some parents lacked the energy required to continue life as they did before the diagnosis.ConclusionsEven though most parents successfully readjusted to a new ‘normality’, reintegrating into daily life after paediatric cancer treatment remains difficult. Professional psychosocial support could help families with the reintegration process. Lastly, clinical staff (eg, physicians, psychologists, social workers) should bear in mind that the burden of parents does not automatically end with the end of intensive cancer treatment.

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