Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation

2011 ◽  
Vol 16 (3) ◽  
pp. 137-144 ◽  
Author(s):  
Timothy M. Connolly ◽  
Hayden Eastwood ◽  
Gordana Kel ◽  
Halina Lisnichuk ◽  
Rachael Richardson ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cochlear Implantation ◽  
Auditory Threshold ◽  
Pig Model ◽  
Threshold Shift ◽  
Guinea Pig Model

scholarly journals Effects of intraoperatively applied glucocorticoid hydrogels on residual hearing and foreign body reaction in a guinea pig model of cochlear implantation

2015 ◽  
Vol 135 (4) ◽  
pp. 313-319 ◽  
Author(s):  
Clemens Honeder ◽  
Lukas David Landegger ◽  
Elisabeth Engleder ◽  
Franz Gabor ◽  
Roberto Plasenzotti ◽  
...  
Keyword(s):  
Foreign Body ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Foreign Body Reaction ◽  
Pig Model ◽  
Residual Hearing ◽  
Guinea Pig Model

Hearing preservation at low frequencies by insulin-like growth factor 1 in a guinea pig model of cochlear implantation

2018 ◽  
Vol 368 ◽  
pp. 92-108 ◽  
Author(s):  
Kohei Yamahara ◽  
Koji Nishimura ◽  
Hideaki Ogita ◽  
Juichi Ito ◽  
Takayuki Nakagawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Hearing Preservation ◽  
Pig Model ◽  
Insulin Like Growth Factor ◽  
Low Frequencies ◽  
Guinea Pig Model

Effects of Round Window Dexamethasone on Residual Hearing in a Guinea Pig Model of Cochlear Implantation

2007 ◽  
Vol 13 (2) ◽  
pp. 86-96 ◽  
Author(s):  
David P. James ◽  
Hayden Eastwood ◽  
Rachael T. Richardson ◽  
Stephen J. O’Leary
Keyword(s):  
Guinea Pig ◽  
Cochlear Implantation ◽  
Round Window ◽  
Pig Model ◽  
Residual Hearing ◽  
Guinea Pig Model

scholarly journals Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation

2019 ◽  
Vol 13 ◽  
Author(s):  
Verena Scheper ◽  
Andrea Hoffmann ◽  
Michael M. Gepp ◽  
André Schulz ◽  
Anika Hamm ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cell ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Pig Model ◽  
Auditory Neurons ◽  
Guinea Pig Model

Effect of a liposomal hyaluronic acid gel loaded with dexamethasone in a guinea pig model after manual or motorized cochlear implantation

2016 ◽  
Vol 274 (2) ◽  
pp. 729-736 ◽  
Author(s):  
Elisabeth Mamelle ◽  
Naila El Kechai ◽  
Benjamin Granger ◽  
Olivier Sterkers ◽  
Amélie Bochot ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Pig Model ◽  
Acid Gel ◽  
Guinea Pig Model ◽  
Hyaluronic Acid Gel

scholarly journals Morphological correlates of hearing loss after cochlear implantation and electro-acoustic stimulation in a hearing-impaired Guinea pig model

2015 ◽  
Vol 327 ◽  
pp. 163-174 ◽  
Author(s):  
Lina A.J. Reiss ◽  
Gemaine Stark ◽  
Anh T. Nguyen-Huynh ◽  
Kayce A. Spear ◽  
Hongzheng Zhang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Acoustic Stimulation ◽  
Hearing Impaired ◽  
Pig Model ◽  
Guinea Pig Model

Effect of Both Local and Systemically Administered Dexamethasone on Long-Term Hearing and Tissue Response in a Guinea Pig Model of Cochlear Implantation

2013 ◽  
Vol 18 (6) ◽  
pp. 392-405 ◽  
Author(s):  
Jason Lee ◽  
Hudaifa Ismail ◽  
Jun Ho Lee ◽  
Gordana Kel ◽  
Jonathan O'Leary ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cochlear Implantation ◽  
Tissue Response ◽  
Pig Model ◽  
Guinea Pig Model

Second Place — Resident Clinical Science Award 1993: Effect of Otologic Drill Noise on ABR Thresholds in a Guinea Pig Model

1993 ◽  
Vol 109 (4) ◽  
pp. 660-667 ◽  
Author(s):  
Gregg W. Suits ◽  
Robert E. Brummett ◽  
Jim Nunley
Keyword(s):  
Guinea Pig ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Pig Model ◽  
Threshold Shift ◽  
Ear Surgery ◽  
Sound Exposure ◽  
Brainstem Response ◽  
Guinea Pig Model ◽  
Mastoid Surgery

The Noise Generated By The Otologic Drill Has Been Implicated As A Cause Of Sensorineural Hearing Loss After Ear Surgery. However, Clinical Studies On This Subject Are Contradictory And Difficult To Interpret. Therefore A Guinea Pig Model Was Used To Study Whether The Level Of Noise Generated By The Otologic Drill Can Cause Threshold Shifts In The Auditory Brainstem Response (Abr). The Source Noise Was A Recording Obtained During A Human Cadaver Mastoidectomy Using A Microphone And An Accelerometer. Ten Female Topeka-Strain Guinea Pigs Were Exposed To The Recorded Drill Noise For A Period Of 55 Minutes. Exposure Included Both Air-Conducted Energy From A Speaker And Bone-Conducted Energy From A Bone Vibrator Applied Directly To The Skull. Abr Threshold Measurements Were Taken Pre-Exposure (Baseline), Immediately After Exposure, And At Weekly Intervals Thereafter For 3 Weeks. Three Control Animals Were Subjected To The Same Procedure Without The Sound Exposure. A Significant Threshold Shift ( P > 0.0001) Was Seen For Each Frequency Tested (2, 4, 8, 16, 20, And 32 Khz) Immediately After Exposure To Noise In All Experimental Animals. Thresholds Returned To Baseline Within 3 Weeks. We Conclude That The Level Of Noise Generated By The Otologic Drill In Mastoid Surgery Can Cause A Temporary Threshold Shift In This Guinea Pig Model

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