Intracranial Internal Carotid Artery Calcification: A Representative for Cerebral Artery Calcification and Association with White Matter Hyperintensities

2010 ◽  
Vol 30 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Pil-Wook Chung ◽  
Kwang-Yeol Park ◽  
Heui-Soo Moon ◽  
Yong-Bum Kim ◽  
Young Chul Youn ◽  
...  
Keyword(s):  
White Matter ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Cerebral Artery ◽  
White Matter Hyperintensities ◽  
Internal Carotid ◽  
Carotid Artery Calcification

Abstract TP205: Association Between Morphological Variations of Extracranial Internal Carotid Artery and Cerebral White Matter Hyperintensities

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Yuying Yan ◽  
Bo Wu ◽  
Yirui Cao ◽  
Shuai Jiang ◽  
Jiayu Sun
Keyword(s):  
White Matter ◽  
Carotid Artery ◽  
Blood Vessel ◽  
Internal Carotid Artery ◽  
White Matter Hyperintensities ◽  
Internal Carotid ◽  
Cerebral White Matter ◽  
Extracranial Internal Carotid Artery ◽  
Morphological Variations ◽  
History Of

Background: Cerebral white matter hyperintensities (WMHs) often remain asymptomatic until they widely affect brain structure. The association between small and large vessel diseases is worth studying. We aimed to explore the relationship between morphological variations of extracranial internal carotid artery (EICA) and WMHs. The classic evaluation system of artery variations failed to describe the compound abnormities, and therefore some novel parameters were proposed in this study. Methods: Neck CT angiography scans and brain MRI data of 97 patients with acute ischemic stroke were retrospectively analyzed. The angle of EICA, tortuosity index (TI), deviation degree (DD) and angular number (AN) were measured as parameters of artery morphological variations (Figure). The severity of WMHs was assessed by Fazekas Scale. Differences of vascular morphological variations between mild and severe white matter lesion groups and factors independently associated with WMHs were analyzed. Results: Compared with the patients with mild WMHs, patients with severe WMHs were older ( P =0.001), had higher average systolic blood pressure ( P =0.026), larger median TI ( P <0.001) and median DD ( P <0.001). Also, more patients with severe WMHs had sharp blood vessel angles ( P =0.001) and history of stroke ( P =0.034). Sharp blood vessel angle (OR 4.056, 95%CI 1.578-10.467) and TI (OR 1.037, 95%CI 1.007-1.068) were independently associated with severe WMHs proved by multivariate logistic analysis. Several regression models suggested that age and history of stroke had close relationship with WMHs. Conclusions: Sharp angle of EICA and TI were independently associated with severe WMHs. Besides, age and history of stroke were firmly related to white matter lesions.

scholarly journals Cerebrovascular disease progression in patients with ACTA2 Arg179 Pathogenic Variants

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011210
Author(s):  
Arne Lauer ◽  
Samantha L. Speroni ◽  
Jay B. Patel ◽  
Ellen Regalado ◽  
Myoung Choi ◽  
...  
Keyword(s):  
White Matter ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Disease Progression ◽  
White Matter Hyperintensities ◽  
Internal Carotid ◽  
White Matter Lesions ◽  
Critical Stenosis ◽  
Pathogenic Variants ◽  
Over Time

Objective:To establish progression of imaging biomarkers of stroke, arterial steno-occlusive disease and white matter injury in patients with smooth muscle dysfunction syndrome caused by mutations in the ACTA2 gene, we analyzed 113 cerebral MRI scans from a retrospective cohort of 27 patients with ACTA2 Arg179 pathogenic variants.Methods:Systematic quantifications of arterial ischemic strokes and white matter lesions were performed on baseline and follow-up scans using planimetric methods. Critical stenosis and arterial vessel diameters were quantified applying manual and semi-automated methods to cerebral MR angiograms. We then assessed correlations between arterial abnormalities and parenchymal injury.Results:We found characteristic patterns of acute white matter ischemic injury and progressive internal carotid artery stenosis during infancy. Longitudinal analysis of patients older than 1.2 years showed stable white matter hyperintensities but increased number of cystic-like lesions over time. Progressive narrowing of the terminal internal carotid artery occurred in 80% of patients and correlated with the number of critical stenosis in cerebral arteries and arterial ischemic infarctions. Arterial ischemic strokes occurred in same territories affected by critical stenosis.Conclusions:We found characteristic, early and progressive cerebrovascular abnormalities in patients with ACTA2 Arg179 pathogenic variants. Our longitudinal data suggests that while steno-occlusive disease progresses over time and is associated with arterial ischemic infarctions and cystic-like white matter lesions; white matter hyperintensities can remain stable over long periods. Above evaluated metrics will enable diagnosis in early infancy and be used to monitor disease progression, guide timing of stroke preventive interventions and assess response to current and future therapies.

Increased tortuosity of bilateral distal internal carotid artery is associated with white matter hyperintensities

2020 ◽  
pp. 028418512093238
Author(s):  
Jiyang Liu ◽  
Xiaoting Ke ◽  
Qingquan Lai
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
White Matter Hyperintensities ◽  
Internal Carotid ◽  
White Matter Hyperintensity ◽  
Intracranial Volume ◽  
Brain White Matter ◽  
Distal Internal Carotid Artery

Background Although the pathophysiology of white matter hyperintensities remains unclear, we can recently explore the possible relationship with white matter hyperintensities by using quantitative parameter. Purpose To demonstrate the relationship between bilateral distal internal carotid arterial tortuosity and total brain white matter hyperintensities volume in elderly individuals. Material and Methods A total of 345 patients (age > 65 years) with brain magnetic resonance (MR) examinations were retrospectively included (44.1% men; mean age = 72.1 ± 6.25 years; 55.9% ≥ 70 years). We measured the Tortuosity Index (TI) of the bilateral distal internal carotid artery and basilar artery on MR angiography imaging, and white matter hyperintensities volume on fluid-attenuated inversion recovery MR sequence. Multiple linear regression was used to assess the association of the TI with quantitatively derived brain white matter hyperintensity volume, after adjusting for demographics (age, sex), vascular risk factors (hypertension, diabetes, heart disease), and vessel diameters, total intracranial volume (TIV). Results Increased tortuosity of bilateral distal internal carotid artery was associated with greater burden of white matter hyperintensity volume (right: β = 11.223, P = 0.016; left: β = 20.701, P < 0.001). This relationship was independent of age and hypertension, both of which have been considered the strongest risk factors for white matter hyperintensities. Conclusion Our results suggest that tortuosity of the bilateral distal internal carotid artery is associated with white matter hyperintensities, independent of age and hypertension.

scholarly journals Blood Pressure, Internal Carotid Artery Flow Parameters, and Age-Related White Matter Hyperintensities

Hypertension ◽  
2014 ◽  
Vol 63 (5) ◽  
pp. 1011-1018 ◽  
Author(s):  
Benjamin S. Aribisala ◽  
Zoe Morris ◽  
Elizabeth Eadie ◽  
Avril Thomas ◽  
Alan Gow ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
White Matter Hyperintensities ◽  
Internal Carotid ◽  
Flow Parameters ◽  
Age Related ◽  
Artery Flow

Quantitative flow measurement after placing a flow diverter for a distal internal carotid artery aneurysm

2016 ◽  
Vol 9 (12) ◽  
pp. 1238-1242 ◽  
Author(s):  
Chien-Wei Chen ◽  
Ho-Fai Wong ◽  
Yu-Ling Ye ◽  
Yao-Liang Chen ◽  
Wei-Liang Chen ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Cerebral Artery ◽  
Internal Carotid ◽  
Flow Diverter ◽  
Peak Time ◽  
Flow Measurements ◽  
Distal Internal Carotid Artery ◽  
Aneurysm Volume ◽  
Quantitative Flow

ObjectivesTo evaluate the differences in arterial flow after flow diverter placement using quantitative flow measurements based on digital subtraction angiography (DSA).MethodsBetween November 2013 and November 2015, all patients who had flow diverters placed for distal internal carotid artery (ICA) aneurysms were reviewed. Patients in whom the stent was placed across the ostia of the ophthalmic artery (OphA) and anterior choroidal artery (AChA) were enrolled. Five regions of interest were selected: the proximal ICA (as a reference), terminal ICA, middle cerebral artery (MCA), anterior cerebral artery (ACA), OphA, and AChA. The values of the peak, time-to-peak (TTP), and area under the curve (AUC) were analyzed using a quantitative DSA technique.ResultsThe study enrolled 13 patients. The quantitative flow analysis showed improved flow in the terminal ICA (peak and AUC, p=0.036 and p=0.04, respectively), MCA (AUC, p=0.023), and ACA (AUC, p=0.006), and decreased flow in the OphA (peak and AUC, p=0.013 and p=0.005, respectively) and AChA (peak and subtracted TTP, p=0.023 and p=0.050, respectively) after flow diverter placement. Larger aneurysm volume was significantly correlated with decreased OphA flow after the procedure (peak and AUC, p=0.049 and p=0.037, respectively). Larger aneurysm volume also had a marginal correlation with increased distal ICA flow after the procedure, but this did not reach significance (peak and AUC, p=0.195 and p=0.060, respectively).ConclusionsWithout using extra contrast medium or radiation dosages, color-coded DSA enables quantitative monitoring of the cerebral circulation after flow-diverting treatment.

scholarly journals Effect of intravenous thrombolysis in stroke depends on pattern of intracranial internal carotid artery calcification

2021 ◽  
Vol 316 ◽  
pp. 8-14
Author(s):  
Frans Kauw ◽  
Pim A. de Jong ◽  
Richard A.P. Takx ◽  
Hugo W.A.M. de Jong ◽  
L. Jaap Kappelle ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Intravenous Thrombolysis ◽  
Carotid Artery Calcification

scholarly journals Intraoperative rupture of cerebral aneurysm and the use of temporary arterial occlusion

2002 ◽  
Vol 59 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Zoran Roganovic ◽  
Goran Pavlicevic
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Cerebral Aneurysm ◽  
Cerebral Artery ◽  
Internal Carotid ◽  
Arterial Occlusion ◽  
Favorable Outcome ◽  
Clinical State ◽  
Aneurysm Size ◽  
Intraoperative Rupture

Objectives: The aim was to analyze the risk factors for intraoperative rupture (IR) of cerebral aneurysm and for temporary clips (TC) use, as well as their influence on the final postoperative outcome. Methods: Retrospective study was done 72 IR patients, and on 75 TC patients. For patients with or without IR, as well as for the patients with or without TK, outcome of the treatment aneurysm size and localization, preoperative clinical state and operative timing was analyzed, and statistical significance of obtained differences was tested. Results: IR occurred in 40% of anterior cerebral artery aneurysms and in 16.7% of internal carotid artery aneurysms (p>0.05), while TCs were used in 52% of middle cerebral artery aneurysms and 34.8% of internal carotid artery aneurysms (p>0.05). Average size was 17.3 mm for aneurysms with IR and 11.7 mm for those without IR (p>0.05). Aneurysms were significantly larger in patients with TCs, than in patients without TCs (16.7 mm and 9.4 mm respectively, p<0.05). Preoperative period was 10.2 days for patients with IR, and 16.8 days for patients without IR (p<0.05). Favorable outcome was observed in 71.4% of patients with IR and in 70.6% of those without IR, as well as in 76.4% of patients who required TC and in 75.6% of cases without TC (p>0.05). Average duration of temporary occlusion was 5.8 min for patients with favorable outcome and 15 min for patients with poor outcome (p<0.05). Conclusions: Incidence of IR mostly depended on the duration of preoperative interval, while the frequency of TC use depended mostly on aneurysm size. IR did not influence the surgical outcome, as well as TC use, if the occlusion was shorter than 8-10 min.

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